Oxidized Phospholipids in Tumor Microenvironment Stimulate Tumor Metastasis via Regulation of Autophagy [PDF]
Cells, 2021 Oxidized phospholipids are well known to play physiological and pathological roles in regulating cellular homeostasis and disease progression. However, their role in cancer metastasis has not been entirely understood.
Jin Kyung Seok +9 more
doaj +5 more sources
Dooming Phagocyte Responses: Inflammatory Effects of Endogenous Oxidized Phospholipids [PDF]
Frontiers in Endocrinology, 2021 Endogenous oxidized phospholipids are produced during tissue stress and are responsible for sustaining inflammatory responses in immune as well as non-immune cells.
Marco Di Gioia, Ivan Zanoni, Ivan Zanoni
doaj +3 more sources
Oxidized Phospholipids and Neutrophil Elastase Coordinately Play Critical Roles in NET Formation [PDF]
Frontiers in Cell and Developmental Biology, 2021 Neutrophil extracellular traps (NETs) are web-like structures consisting of decondensed chromatin DNA and contents of granules, such as myeloperoxidase (MPO) and neutrophil elastase (NE).
Takuto Tokuhiro +16 more
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Oxidized Phospholipids in Healthy and Diseased Lung Endothelium [PDF]
Cells, 2020 Circulating and cell membrane phospholipids undergo oxidation caused by enzymatic and non-enzymatic mechanisms. As a result, a diverse group of bioactive oxidized phospholipids generated in these conditions have both beneficial and harmful effects on the
Pratap Karki, Konstantin G. Birukov
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Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency [PDF]
Circulation, 2021 Supplemental Digital Content is available in the text. Background: LNK/SH2B3 inhibits Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling by hematopoietic cytokine receptors.
Huijuan Dou +19 more
semanticscholar +4 more sources
Oxidized phospholipids cause changes in jejunum mucus that induce dysbiosis and systemic inflammation [PDF]
Journal of Lipid Research, 2022 We previously reported that adding a concentrate of transgenic tomatoes expressing the apoA-I mimetic peptide 6F (Tg6F) to a Western diet (WD) ameliorated systemic inflammation.
Pallavi Mukherjee +11 more
doaj +3 more sources
Neutralization of oxidized phospholipids attenuates age‐associated bone loss in mice [PDF]
Aging Cell, 2021 Oxidized phospholipids (OxPLs) are pro‐inflammatory molecules that affect bone remodeling under physiological conditions. Transgenic expression of a single‐chain variable fragment (scFv) of the antigen‐binding domain of E06, an IgM natural antibody that ...
M. Palmieri +10 more
semanticscholar +2 more sources
Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis [PDF]
Sci Adv, 2022 Oxidized phosphatidylcholines (OxPCs) are implicated in chronic tissue damage. Hyperlipidemic LDL-R-–deficient mice transgenic for an OxPC-recognizing IgM fragment (scFv-E06) are protected against nonalcoholic fatty liver disease (NAFLD).
Clint M. Upchurch +10 more
semanticscholar +2 more sources
Lipoprotein(a), Oxidized Phospholipids, and Progression to Symptomatic Heart Failure: The CASABLANCA Study [PDF]
J Am Heart AssocBackground Higher lipoprotein(a) and oxidized phospholipid concentrations are associated with increased risk for coronary artery disease and valvular heart disease.
J. Januzzi +8 more
semanticscholar +2 more sources
Oxidized Phospholipids in Control of Endothelial Barrier Function: Mechanisms and Implication in Lung Injury [PDF]
Front Endocrinol (Lausanne), 2021 Earlier studies investigating the pathogenesis of chronic vascular inflammation associated with atherosclerosis described pro-inflammatory and vascular barrier disruptive effects of lipid oxidation products accumulated in the sites of vascular lesion and
P. Karki, K. Birukov
semanticscholar +2 more sources