Results 11 to 20 of about 505,050 (297)

Lipoprotein(a), Oxidized Phospholipids, and Progression to Symptomatic Heart Failure: The CASABLANCA Study. [PDF]

J Am Heart Assoc
Background Higher lipoprotein(a) and oxidized phospholipid concentrations are associated with increased risk for coronary artery disease and valvular heart disease.
Januzzi JL, van Kimmenade RRJ, Liu Y, Hu X, Browne A, Plutzky J, Tsimikas S, Blankstein R, Natarajan P.   +8 more
europepmc   +2 more sources

Oxidized Phospholipids in Control of Endothelial Barrier Function: Mechanisms and Implication in Lung Injury. [PDF]

Front Endocrinol (Lausanne), 2021
Earlier studies investigating the pathogenesis of chronic vascular inflammation associated with atherosclerosis described pro-inflammatory and vascular barrier disruptive effects of lipid oxidation products accumulated in the sites of vascular lesion and
Karki P, Birukov KG.
europepmc   +2 more sources

Toxicity of oxidized phospholipids in cultured macrophages [PDF]

Lipids in Health and Disease, 2012
Background The interactions of oxidized low-density lipoprotein (LDL) and macrophages are hallmarks in the development of atherosclerosis. The biological activities of the modified particle in these cells are due to the content of lipid oxidation ...
Stemmer Ute, Dunai Zsuzsanna A, Koller Daniel, Pürstinger Gabriel, Zenzmaier Elfriede, Deigner Hans P, Aflaki Elma, Kratky Dagmar, Hermetter Albin   +8 more
doaj   +5 more sources

The role of oxidized phospholipids in atherosclerosis

Journal of Lipid Research, 2009
There is increasing evidence that oxidized phospholipids (OxPLs) play an important role in atherosclerosis. These phospholipids accumulate in human and mouse lesions.
Judith A. Berliner, Norbert Leitinger, Sotirios Tsimikas   +2 more
doaj   +3 more sources

Simplified synthesis of oxidized phospholipids on alkyl-amide scaffold [PDF]

MethodsX
Oxidized phospholipids (OxPLs), containing oxidized fatty acids (oxylipins), play a significant role in various diseases. However, studying the structure-activity relationships of OxPLs and their signaling mechanisms is challenging due to the complexity ...
Olga V. Oskolkova, Bernd Gesslbauer, Valery Bochkov   +2 more
doaj   +2 more sources

Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells

Nature Communications, 2018
During atherosclerosis, endothelial cells release purines in response to oxidized phospholipids. Here, Hitzel et al. show that oxidized phospholipids activate an MTHFD2-regulated gene network in endothelial cells which reprograms amino acid metabolism ...
Juliane Hitzel, Eunjee Lee, Yi Zhang, Sofia Iris Bibli, Xiaogang Li, Sven Zukunft, Beatrice Pflüger, Jiong Hu, Christoph Schürmann, Andrea Estefania Vasconez, James A. Oo, Adelheid Kratzer, Sandeep Kumar, Flávia Rezende, Ivana Josipovic, Dominique Thomas, Hector Giral, Yannick Schreiber, Gerd Geisslinger, Christian Fork, Xia Yang, Fragiska Sigala, Casey E. Romanoski, Jens Kroll, Hanjoong Jo, Ulf Landmesser, Aldons J. Lusis, Dmitry Namgaladze, Ingrid Fleming, Matthias S. Leisegang, Jun Zhu, Ralf P. Brandes   +31 more
doaj   +2 more sources

Pain Control by Targeting Oxidized Phospholipids: Functions, Mechanisms, Perspectives [PDF]

Frontiers in Endocrinology, 2021
Within the lipidome oxidized phospholipids (OxPL) form a class of chemically highly reactive metabolites. OxPL are acutely produced in inflamed tissue and act as endogenous, proalgesic (pain-inducing) metabolites. They excite sensory, nociceptive neurons
Beatrice Oehler, Beatrice Oehler, Beatrice Oehler, Alexander Brack, Robert Blum, Heike L. Rittner   +5 more
doaj   +2 more sources

Lipoprotein(a), Oxidized Phospholipids, and Coronary Artery Disease Severity and Outcomes. [PDF]

J Am Coll Cardiol, 2023
Gilliland TC, Liu Y, Mohebi R, Miksenas H, Haidermota S, Wong M, Hu X, Cristino JR, Browne A, Plutzky J, Tsimikas S, Januzzi JL, Natarajan P.   +12 more
europepmc   +2 more sources

Oxidized phospholipid damage signals as modulators of immunity

Open Biology
Damage-associated molecular patterns (DAMPs) are self-derived molecules released during tissue damage that influence immune responses. Phospholipids, essential to cell membranes and lung surfactants, become oxidized under conditions of cellular stress ...
Joon H. Choi, Jonathan C. Kagan
doaj   +2 more sources

Low Concentrations of Oxidized Phospholipids Increase Stress Tolerance of Endothelial Cells [PDF]

Antioxidants, 2022
Oxidized phospholipids (OxPLs) are generated by enzymatic or autooxidation of esterified polyunsaturated fatty acids (PUFAs) residues. OxPLs are present in circulation and atherosclerotic plaques where they are thought to induce predominantly ...
Christina Mauerhofer, Taras Afonyushkin, Olga V. Oskolkova, Klara Hellauer, Bernd Gesslbauer, Jasmin Schmerda, Yunbo Ke, Andreas Zimmer, Anna A. Birukova, Konstantin G. Birukov, Valery Bochkov   +10 more
doaj   +2 more sources