Results 21 to 30 of about 505,050 (297)

Macrophage phenotype and bioenergetics are controlled by oxidized phospholipids identified in lean and obese adipose tissue

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Adipose tissue macrophages (ATMs) maintain adipose tissue homeostasis. However, during obesity ATMs become inflammatory, resulting in impaired adipose tissue function. Oxidative stress increases during obesity, which is thought to contribute
Vlad Serbulea, Clint M. Upchurch, Michael S. Schappe, Paxton Voigt, Dory E. DeWeese, Bimal N. Desai, Akshaya K. Meher, Norbert Leitinger   +7 more
openalex   +3 more sources

Associations between lipoprotein(a), oxidized phospholipids, and extracoronary vascular disease [PDF]

Journal of Lipid Research
The roles of lipoprotein(a) [Lp(a)] and related oxidized phospholipids (OxPLs) in the development and progression of coronary disease is known, but their influence on extracoronary vascular disease is not well-established.
Tiffany R. Bellomo, Yuxi Liu, Thomas C. Gilliland, Hannah Miksenas, Sara Haidermota, Megan Wong, Xingdi Hu, Joaquim Rosado Cristino, Auris Browne, Jorge Plutzky, Sotirios Tsimikas, James L. Januzzi, Jr., Pradeep Natarajan   +12 more
doaj   +2 more sources

Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation. [PDF]

Nat Immunol, 2020
Pathogen-associated molecular patterns (PAMPs) have the capacity to couple inflammatory gene expression to changes in macrophage metabolism, both of which influence subsequent inflammatory activities. Similar to their microbial counterparts, several self-
Di Gioia M, Spreafico R, Springstead JR, Mendelson MM, Joehanes R, Levy D, Zanoni I.   +6 more
europepmc   +2 more sources

The regulation of inflammation by oxidized phospholipids [PDF]

European Journal of Immunology, 2016
During inflammation or under conditions of oxidative stress, the polyunsaturated fatty acid side chains of phospholipids in cellular membranes or lipoproteins can be oxidatively modified. This process generates a complex mixture of structurally diverse oxidized phospholipid (OxPL) species, each of which may exert distinct biological effects.
S. Freigang
semanticscholar   +4 more sources

Oxidized phospholipids, isolevuglandins, and atherosclerosis [PDF]

Molecular Nutrition & Food Research, 2005
Autoxidation of polyunsaturated phosphatidylcholines (PCs) generates isolevuglandins (isoLGs) through rearrangements of isoprostanoid endoperoxides. Within seconds, isoLGs are sequestered by covalent adduction with proteins. Murine plasma isoLG-protein levels increased at least 2.5-fold in response to inflammation.
Wujuan Zhang, Robert G. Salomon
openalex   +3 more sources

Pleiotropic effects of oxidized phospholipids.

Free Radical Biology and Medicine, 2017
Oxidized phospholipids (OxPLs) are increasingly recognized to play a role in a variety of normal and pathological states. OxPLs were implicated in regulation of inflammation, thrombosis, angiogenesis, endothelial barrier function, immune tolerance and other important processes.
V. Bochkov, B. Gesslbauer, Christina Mauerhofer, M. Philippova, P. Erne, O. Oskolkova   +5 more
semanticscholar   +3 more sources

PCSK9 Inhibition and Oxidized Phospholipids. [PDF]

J Am Coll Cardiol, 2021
Bhatia HS, Yeang C, Baruch A, Yang X, Stroes ESG, Tsimikas S.   +5 more
europepmc   +2 more sources

Reduction of myocardial ischaemia-reperfusion injury by inactivating oxidized phospholipids. [PDF]

Cardiovasc Res, 2019
Aims Myocardial ischaemia followed by reperfusion (IR) causes an oxidative burst resulting in cellular dysfunction. Little is known about the impact of oxidative stress on cardiomyocyte lipids and their role in cardiac cell death.
Yeang C, Hasanally D, Que X, Hung MY, Stamenkovic A, Chan D, Chaudhary R, Margulets V, Edel AL, Hoshijima M, Gu Y, Bradford W, Dalton N, Miu P, Cheung DY, Jassal DS, Pierce GN, Peterson KL, Kirshenbaum LA, Witztum JL, Tsimikas S, Ravandi A.   +21 more
europepmc   +2 more sources

A Role for Oxidized Phospholipids in Atherosclerosis [PDF]

New England Journal of Medicine, 2005
Judith A, Berliner, Andrew D, Watson
openalex   +3 more sources

Lp(a), oxidized phospholipids and oxidation-specific epitopes are increased in subjects with keloid formation. [PDF]

Lipids Health Dis, 2022
Ruder S, Mansfield B, Immelman AR, Varki N, Miu P, Raal F, Tsimikas S.   +6 more
europepmc   +3 more sources