Results 31 to 40 of about 506,293 (263)

Specific monocyte adhesion to endothelial cells induced by oxidized phospholipids involves activation of cPLA2 and lipoxygenase

Journal of Lipid Research, 2006
Oxidized phospholipids stimulate endothelial cells to bind monocytes, but not neutrophils, an initiating event in atherogenesis. Here, we investigate intracellular signaling events induced by oxidized phospholipids in human umbilical vein endothelial ...
Joakim Huber, Alexander Fuärnkranz, Valery N. Bochkov, Mary K. Patricia, Hans Lee, Catherine C. Hedrick, Judith A. Berliner, Bernd R. Binder, Norbert Leitinger   +8 more
doaj   +1 more source

The Biosynthesis of Enzymatically Oxidized Lipids

Frontiers in Endocrinology, 2020
Enzymatically oxidized lipids are a specific group of biomolecules that function as key signaling mediators and hormones, regulating various cellular and physiological processes from metabolism and cell death to inflammation and the immune response. They
Ali A. Hajeyah, William J. Griffiths, Yuqin Wang, Andrew J. Finch, Valerie B. O’Donnell   +4 more
doaj   +1 more source

Thematic review series: The Pathogenesis of Atherosclerosis The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL

Journal of Lipid Research, 2004
For more than two decades, there has been continuing evidence of lipid oxidation playing a central role in atherogenesis. The oxidation hypothesis of atherogenesis has evolved to focus on specific proinflammatory oxidized phospholipids that result from ...
Mohamad Navab, G.M. Ananthramaiah, Srinivasa T. Reddy, Brian J. Van Lenten, Benjamin J. Ansell, Gregg C. Fonarow, Kambiz Vahabzadeh, Susan Hama, Greg Hough, Naeimeh Kamranpour, Judith A. Berliner, Aldons J. Lusis, Alan M. Fogelman   +12 more
doaj   +1 more source

Regulation of interleukin-6 expression in osteoblasts by oxidized phospholipids

Journal of Lipid Research, 2010
Epidemiological evidence suggests that cardiovascular disease is associated with osteoporosis, independent of age. Bone resorptive surface is increased in mice on a high-fat diet, and osteoclastic differentiation of bone marrow preosteoclasts is promoted
Wendy Tseng, Jinxiu Lu, Gail A. Bishop, Andrew D. Watson, Andrew P. Sage, Linda Demer, Yin Tintut   +6 more
doaj   +1 more source

Toxicity of oxidized phospholipids in cultured macrophages

Lipids in Health and Disease, 2012
Background The interactions of oxidized low-density lipoprotein (LDL) and macrophages are hallmarks in the development of atherosclerosis. The biological activities of the modified particle in these cells are due to the content of lipid oxidation ...
Stemmer Ute, Dunai Zsuzsanna A, Koller Daniel, Pürstinger Gabriel, Zenzmaier Elfriede, Deigner Hans P, Aflaki Elma, Kratky Dagmar, Hermetter Albin   +8 more
doaj   +1 more source

Identification of short-chain oxidized phosphatidylcholine in human plasma

Journal of Lipid Research, 1996
Oxidized phospholipids have been recognized as potentially important compounds that carry biological activities similar to the platelet-activating factor, but their presence in biological tissue has not been firmly established.
M Schlame, R Haupt, I Wiswedel, W J Kox, B Rüstow   +4 more
doaj   +1 more source

Protein targets of oxidized phospholipids in endothelial cellss⃞

Journal of Lipid Research, 2008
Oxidation products of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphatidylcholine (Ox-PAPC) are found in atherosclerotic lesions, apoptotic cells, and oxidized LDL and stimulate human aortic endothelial cells (HAECs) to produce inflammatory cytokines ...
B. Gabriel Gugiu, Kevin Mouillesseaux, Victoria Duong, Tabitha Herzog, Avetis Hekimian, Lukasz Koroniak, Thomas M. Vondriska, Andrew D. Watson   +7 more
doaj   +1 more source

Phospholipid Membrane Transport and Associated Diseases

Biomedicines, 2022
Phospholipids are the basic structure block of eukaryotic membranes, in both the outer and inner membranes, which delimit cell organelles. Phospholipids can also be damaged by oxidative stress produced by mitochondria, for instance, becoming oxidized ...
Raúl Ventura, Inma Martínez-Ruiz, María Isabel Hernández-Alvarez   +2 more
doaj   +1 more source

Cholesteryl ester acyl oxidation and remodeling in murine macrophages: formation of oxidized phosphatidylcholine[S]

Journal of Lipid Research, 2012
Cholesterol is an essential component of eukaryotic cell membranes, regulating fluidity and permeability of the bilayer. Outside the membrane, cholesterol is esterified to fatty acids forming cholesterol esters (CEs).
Patrick M. Hutchins, Robert C. Murphy
doaj   +1 more source

Oxidized phospholipids, linked to apolipoprotein B of oxidized LDL, are ligands for macrophage scavenger receptors

Journal of Lipid Research, 2000
Previous studies have shown that macrophage receptors for oxidized LDL (OxLDL) recognize both the lipid and protein moieties, and that a monoclonal antibody against OxLDL, EO6, also recognizes both species.
Kristin L. Gillotte, Sohvi Hörkkö, Joseph L. Witztum, Daniel Steinberg   +3 more
doaj   +1 more source