Results 41 to 50 of about 506,293 (263)

The role of oxidized phospholipids in atherosclerosis

Journal of Lipid Research, 2009
There is increasing evidence that oxidized phospholipids (OxPLs) play an important role in atherosclerosis. These phospholipids accumulate in human and mouse lesions.
Judith A. Berliner, Norbert Leitinger, Sotirios Tsimikas   +2 more
doaj   +1 more source

A novel role for 12/15-lipoxygenase in regulating autophagy

Redox Biology, 2015
12/15-Lipoxygenase (LOX) enzymatically generates oxidized phospholipids in monocytes and macrophages. Herein, we show that cells deficient in 12/15-LOX contain defective mitochondria and numerous cytoplasmic vacuoles containing electron dense material ...
Alwena H. Morgan, Victoria J. Hammond, Machiko Sakoh-Nakatogawa, Yoshinori Ohsumi, Christopher P. Thomas, Fabien Blanchet, Vincent Piguet, Kirill Kiselyov, Valerie B. O’Donnell   +8 more
doaj   +1 more source

Oxidized Phospholipids are Proinflammatory and Proatherogenic in Hypercholesterolemic Mice

Nature, 2018
Oxidized phospholipids (OxPL) are ubiquitous, are formed in many inflammatory tissues, including atherosclerotic lesions, and frequently mediate proinflammatory changes1.
X. Que, Ming-Yow Hung, C. Yeang, A. Gonen, T. Prohaska, Xiaoli Sun, Cody J. Diehl, Antti Määttä, Dalia E. Gaddis, Karen Bowden, J. Pattison, Jeffrey G. MacDonald, S. Ylä-Herttuala, P. Mellon, C. Hedrick, K. Ley, Yury I. Miller, C. Glass, K. Peterson, C. Binder, S. Tsimikas, J. Witztum   +21 more
semanticscholar   +1 more source

Enzymatically oxidized phospholipids assume center stage as essential regulators of innate immunity and cell death

Science Signaling, 2019
Enzymatically oxidized phospholipids have important functions in normal physiology and disease states. Gloss Lipids that are generated by enzymes in circulating blood cells through controlled oxidation of biomembranes have been discovered.
V. O’Donnell, Maceler Aldrovandi, R. Murphy, Gerhard Krönke   +3 more
semanticscholar   +1 more source

Phosphocholine as a pattern recognition ligand for CD361

Journal of Lipid Research, 2005
We have previously shown that CD36 recognizes oxidation products of phospholipids on oxidized LDL (OxLDL) such as 1-palmitoyl-2-(5′-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC). The current study was designed to examine whether the phosphocholine (PC)
Agnès Boullier, Peter Friedman, Richard Harkewicz, Karsten Hartvigsen, Simone R. Green, Felicidad Almazan, Edward A. Dennis, Daniel Steinberg, Joseph L. Witztum, Oswald Quehenberger   +9 more
doaj   +1 more source

Structural characterization of oxidized phospholipid products derived from arachidonate-containing plasmenyl glycerophosphocholine

Journal of Lipid Research, 2000
Plasmenyl phospholipids are a structurally unique class of lipids that contain a vinyl ether substituent at the sn-1 position of the glycerol backbone, imparting unique susceptibility to oxidative reactions that may take place at the cell membrane lipid ...
Nona Khaselev, Robert C. Murphy
doaj   +1 more source

Potential Causality and Emerging Medical Therapies for Lipoprotein(a) and Its Associated Oxidized Phospholipids in Calcific Aortic Valve Stenosis.

Circulation Research, 2019
The prevalence of calcific aortic valve disease is increasing with aging of the population. Current treatment options for advanced or symptomatic aortic stenosis are limited to traditional surgical or percutaneous aortic valve replacement.
S. Tsimikas
semanticscholar   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Tg6F ameliorates the increase in oxidized phospholipids in the jejunum of mice fed unsaturated LysoPC or WD[S]

Journal of Lipid Research, 2016
Mouse chow supplemented with lysophosphatidylcholine with oleic acid at sn-1 and a hydroxyl group at sn-2 (LysoPC 18:1) increased LysoPC 18:1 in tissue of the jejunum of LDL receptor (LDLR)-null mice by 8.9 ± 1.7-fold compared with chow alone.
Arnab Chattopadhyay, Mohamad Navab, Greg Hough, Victor Grijalva, Pallavi Mukherjee, Hannah R. Fogelman, Lin H. Hwang, Kym F. Faull, Aldons J. Lusis, Srinivasa T. Reddy, Alan M. Fogelman   +10 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source