Results 51 to 60 of about 505,050 (297)

Cholesteryl ester acyl oxidation and remodeling in murine macrophages: formation of oxidized phosphatidylcholine[S]

Journal of Lipid Research, 2012
Cholesterol is an essential component of eukaryotic cell membranes, regulating fluidity and permeability of the bilayer. Outside the membrane, cholesterol is esterified to fatty acids forming cholesterol esters (CEs).
Patrick M. Hutchins, Robert C. Murphy
doaj   +1 more source

A novel role for 12/15-lipoxygenase in regulating autophagy

Redox Biology, 2015
12/15-Lipoxygenase (LOX) enzymatically generates oxidized phospholipids in monocytes and macrophages. Herein, we show that cells deficient in 12/15-LOX contain defective mitochondria and numerous cytoplasmic vacuoles containing electron dense material ...
Alwena H. Morgan, Victoria J. Hammond, Machiko Sakoh-Nakatogawa, Yoshinori Ohsumi, Christopher P. Thomas, Fabien Blanchet, Vincent Piguet, Kirill Kiselyov, Valerie B. O’Donnell   +8 more
doaj   +1 more source

Generation and Biological Activities of Oxidized Phospholipids [PDF]

Antioxidants & Redox Signaling, 2010
Glycerophospholipids represent a common class of lipids critically important for integrity of cellular membranes. Oxidation of esterified unsaturated fatty acids dramatically changes biological activities of phospholipids. Apart from impairment of their structural function, oxidation makes oxidized phospholipids (OxPLs) markers of "modified-self" type ...
Valery N, Bochkov, Olga V, Oskolkova, Konstantin G, Birukov, Anna-Liisa, Levonen, Christoph J, Binder, Johannes, Stöckl   +5 more
openaire   +2 more sources

Phosphocholine as a pattern recognition ligand for CD361

Journal of Lipid Research, 2005
We have previously shown that CD36 recognizes oxidation products of phospholipids on oxidized LDL (OxLDL) such as 1-palmitoyl-2-(5′-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC). The current study was designed to examine whether the phosphocholine (PC)
Agnès Boullier, Peter Friedman, Richard Harkewicz, Karsten Hartvigsen, Simone R. Green, Felicidad Almazan, Edward A. Dennis, Daniel Steinberg, Joseph L. Witztum, Oswald Quehenberger   +9 more
doaj   +1 more source

Structural characterization of oxidized phospholipid products derived from arachidonate-containing plasmenyl glycerophosphocholine

Journal of Lipid Research, 2000
Plasmenyl phospholipids are a structurally unique class of lipids that contain a vinyl ether substituent at the sn-1 position of the glycerol backbone, imparting unique susceptibility to oxidative reactions that may take place at the cell membrane lipid ...
Nona Khaselev, Robert C. Murphy
doaj   +1 more source

Enzymatically oxidized phospholipids assume center stage as essential regulators of innate immunity and cell death

Science Signaling, 2019
Enzymatically oxidized phospholipids have important functions in normal physiology and disease states. Gloss Lipids that are generated by enzymes in circulating blood cells through controlled oxidation of biomembranes have been discovered.
V. O’Donnell, Maceler Aldrovandi, R. Murphy, Gerhard Krönke   +3 more
semanticscholar   +1 more source

Role of Phospholipid Oxidation Products in Atherosclerosis [PDF]

Circulation Research, 2012
There is increasing clinical evidence that phospholipid oxidation products (Ox-PL) play a role in atherosclerosis. This review focuses on the mechanisms by which Ox-PL interact with endothelial cells, monocyte/macrophages, platelets, smooth muscle cells, and HDL to promote atherogenesis. In the past few years major progress has been made in identifying
Sangderk, Lee, Konstantin G, Birukov, Casey E, Romanoski, James R, Springstead, Aldons J, Lusis, Judith A, Berliner   +5 more
openaire   +2 more sources

Tg6F ameliorates the increase in oxidized phospholipids in the jejunum of mice fed unsaturated LysoPC or WD[S]

Journal of Lipid Research, 2016
Mouse chow supplemented with lysophosphatidylcholine with oleic acid at sn-1 and a hydroxyl group at sn-2 (LysoPC 18:1) increased LysoPC 18:1 in tissue of the jejunum of LDL receptor (LDLR)-null mice by 8.9 ± 1.7-fold compared with chow alone.
Arnab Chattopadhyay, Mohamad Navab, Greg Hough, Victor Grijalva, Pallavi Mukherjee, Hannah R. Fogelman, Lin H. Hwang, Kym F. Faull, Aldons J. Lusis, Srinivasa T. Reddy, Alan M. Fogelman   +10 more
doaj   +1 more source

Potential Causality and Emerging Medical Therapies for Lipoprotein(a) and Its Associated Oxidized Phospholipids in Calcific Aortic Valve Stenosis.

Circulation Research, 2019
The prevalence of calcific aortic valve disease is increasing with aging of the population. Current treatment options for advanced or symptomatic aortic stenosis are limited to traditional surgical or percutaneous aortic valve replacement.
S. Tsimikas
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source