Results 41 to 50 of about 8,623 (211)

Thiation of Oxindoles

Chemical and Pharmaceutical Bulletin, 1969
The thiation of methyl substituted oxindoles (I) with phosphorous pentasulfide gave the corresponding 2-indolinethiones (II). The 2-indolinethione (II) having more than one hydrogen at 3-position, however, were sensitive towards phosphorous pentasulfide to produce the indolic compounds such as III, IV, V and VI.
TOHRU HINO, KAZUKO TSUNEOKA, MASAKO NAKAGAWA, SANYA AKABOSHI   +3 more
openaire   +2 more sources

Asymmetric Ugi 3CR on isatin-derived ketimine: synthesis of chiral 3,3-disubstituted 3-aminooxindole derivatives

Beilstein Journal of Organic Chemistry, 2014
An efficient Ugi three-component reaction of a preformed chiral ketimine derived from isatin with various isonitrile and acid components has been developed.
Giordano Lesma, Fiorella Meneghetti, Alessandro Sacchetti, Mattia Stucchi, Alessandra Silvani   +4 more
doaj   +1 more source

Microwave‐Assisted Organic Syntheses in Deep Eutectic Solvents: A Win‐Win Association for Sustainable Chemistry

ChemistryOpen, EarlyView.
In organic synthesis, deep eutectic solvents (DES) have demonstrated their ability to be used as reaction media for the development of reactions in line with green chemistry principles. This review presents an overview of microwave‐assisted organic synthesis in DES, highlighting the diversity of uses for these solvents, their role in mechanisms, the ...
Pierre‐Olivier Delaye, Chefikou Salami, Emilie Thiery   +2 more
wiley   +1 more source

A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives

Molecules, 2020
The hydroxy-pyrazole and 3-hydroxy-oxindole motifs have been utilised in several pharma and agrochemical leads but are distinctly underrepresented in the scientific literature due to the limited routes of preparation.
Guido Gambacorta, David C. Apperley, Ian R. Baxendale   +2 more
doaj   +1 more source

Ensemble Docking of FDA‐Approved and Peruvian Phytochemicals Against Monkeypox Virus Telomere‐Binding Protein

ChemistrySelect, Volume 11, Issue 9, 5 March 2026.
ABSTRACT Monkeypox is a reemerging zoonotic disease that has been spreading worldwide. Different approaches are being conducted to find effective treatments for this disease. To accelerate therapeutic discovery, we propose telomere‐binding protein (TBP) as a potential drug target because of its important role during virus maturation.
Edinson Gervacio‐Villarreal, Georcki Ropón‐Palacios, Claudina Sancho, Jhon Pérez‐Silva, Kewin Otazu, Gustavo E. Olivos‐Ramirez, Karolyn Vega‐Chozo, Yaritza L. Ramirez‐Díaz, Manuel E. Chenet‐Zuta, Ivonne Navarro del Aguila, Mario De la Cruz Flores, Cinthia Aguiar, Ihosvany Camps   +12 more
wiley   +1 more source

Ag/Pyridine Co-Mediated Oxidative Arylthiocyanation of Activated Alkenes

Molecules, 2018
An efficient Ag/pyridine co-mediated oxidative arylthiocyanation of activated alkenes via radical addition/cyclization cascade process was developed.
De-Long Kong, Jian-Xun Du, Wei-Ming Chu, Chun-Ying Ma, Jia-Yi Tao, Wen-Hua Feng   +5 more
doaj   +1 more source

Novel Application of UHPLC–MS, HRMS, and 2D‐NMR for Structural Elucidation of Eletriptan Hydrobromide and Its Novel Degradation Products

Biomedical Chromatography, Volume 40, Issue 2, February 2026.
ABSTRACT A stability‐indicating UHPLC–MS method was developed to investigate the stress degradation behavior of eletriptan hydrobromide under ICH‐recommended acidic, alkaline, neutral, oxidative, thermal, and photolytic conditions. Significant degradation was observed only under acidic and oxidative stress.
Dastagiri Reddy Bhuma, Venkata Kanaka Srivani Maddala, Suresh Salakolasu, Naresh Kumar Katari   +3 more
wiley   +1 more source

Environmental Influence on the Untargeted Foliar Metabolome of Naturally Growing Mitragyna Species in Thailand

Plant-Environment Interactions, Volume 7, Issue 1, February 2026.
ABSTRACT This study investigates the foliar secondary metabolite profiles of four Mitragyna species naturally occurring in Thailand: M. diversifolia, M. hirsuta, M. rotundifolia, and M. speciosa (kratom). Using untargeted gas chromatography–mass spectrometry (GC–MS), 409 secondary volatile metabolites were annotated across the four species.
Tushar Andriyas, Nisa Leksungnoen, Chatchai Ngernsaengsaruay, Suwimon Uthairatsamee, Rossarin Tansawat, Pakawat Sirilertpanich   +5 more
wiley   +1 more source

The Ugi4CR as effective tool to access promising anticancer isatin-based α-acetamide carboxamide oxindole hybrids

Beilstein Journal of Organic Chemistry
Considering early-stage drug discovery programs, the Ugi four-component reaction is a valuable, flexible, and pivotal tool, facilitating the creation of two new amide bonds in a one-pot fashion to effectively yield the desired α-aminoacylamides. Here, we
Carolina S. Marques, Aday González-Bakker, José M. Padrón   +2 more
doaj   +1 more source

Chiral ammonium betaine-catalyzed asymmetric Mannich-type reaction of oxindoles

Beilstein Journal of Organic Chemistry, 2016
A highly diastereo- and enantioselective Mannich-type reaction of 3-aryloxindoles with N-Boc aldimines was achieved under the catalysis of axially chiral ammonium betaines.
Masahiro Torii, Kohsuke Kato, Daisuke Uraguchi, Takashi Ooi   +3 more
doaj   +1 more source