Results 51 to 60 of about 8,623 (211)

Approved Small-Molecule ATP-Competitive Kinases Drugs Containing Indole/Azaindole/Oxindole Scaffolds: R&D and Binding Patterns Profiling

Molecules, 2023
Kinases are among the most important families of biomolecules and play an essential role in the regulation of cell proliferation, apoptosis, metabolism, and other critical physiological processes. The dysregulation and gene mutation of kinases are linked
Haofan Zhang, Fengming He, Guiping Gao, Sheng Lu, Qiaochu Wei, Hongyu Hu, Zhen Wu, Meijuan Fang, Xiumin Wang   +8 more
doaj   +1 more source

Identification of 3-Oxindole Derivatives as Small Molecule HIV-1 Inhibitors Targeting Tat-Mediated Viral Transcription

Molecules, 2022
The heterocyclic indole structure has been shown to be one of the most promising scaffolds, offering various medicinal advantages from its wide range of biological activity. Nonetheless, the significance of 3-oxindole has been less known.
Dong-Eun Kim, Young Hyun Shin, Jung-Eun Cho, Subeen Myung, Hong Gi Kim, Kyung-Chang Kim, Chul Min Park, Cheol-Hee Yoon   +7 more
doaj   +1 more source

Unprecedented, catalyst‐free, and rapid one‐pot, three‐component green synthesis of substituted 3‐hydroxy‐2‐oxindoles in water [PDF]

, 2023
Mayur G. Patil, Ganesh A. Thakur, Rupashri K. Kadu, Pramod B. Thakur   +3 more
openalex   +1 more source

Synthesis biological evaluation and molecular docking of isatin hybrids as anti-cancer and anti-microbial agents

Journal of Enzyme Inhibition and Medicinal Chemistry
Isatin, known as 1H-indole-2,3-dione, was originally recognised as a synthetic molecule until its discovery in the fruits of the cannonball tree, Couroupita guianensis.
Mohammad Altamimi, Saeed Ali Syed, Burak Tuzun, Mohammad Rashid Alhazani, Osamah Alnemer, Ahmed Bari   +5 more
doaj   +1 more source

tert-Butyl Hypochlorite: A Reagent for the Synthesis of Chlorinated Oxindole and Indole Derivatives

Molecules
tert-Butyl hypochlorite was employed as a versatile reagent for chlorooxidation of indoles, chlorination of 2-oxindoles, and decarboxylative chlorination of the indole-2-carboxylic acids.
Chun-Yan Liu, Xia Chen, Hai-Long Liu, Nan Wang, Xiao-Yu Zhou   +4 more
doaj   +1 more source

A Flavonoid‐Rich Extract of Scoparia dulcis L. Exhibits Antiviral Activity against Herpes Virus Type 1

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT This study investigated the phytochemical profile, cytotoxicity, and anti‐herpetic activity of the hydroethanolic extract from Scoparia dulcis L. aerial parts. Mass spectrometry revealed the presence of 15 compounds. The extract showed low cytotoxicity in Vero cells, maintaining over 80% viability at concentrations up to 250 µg/mL.
Francisco Leandro Medeiros de Lucena Jales, Emerson Michell da Silva Siqueira, Renato Dantas‐Medeiros, Edilane Rodrigues Dantas de Araújo, Jovelina Samara Ferreira Alves, Hugo Alexandre de Oliveira Rocha, Norberto Peporine Lopes, Leandro de Santis Ferreira, Emanuella de Aragão Tavares, Silvana Maria Zucolotto   +9 more
wiley   +1 more source

Facile synthesis of functionalized spiro[indoline-3,2'-oxiran]-2-ones by Darzens reaction

Beilstein Journal of Organic Chemistry, 2013
A series of functionalized spiro[indoline-3,2'-oxiran]-2-ones was efficiently synthesized by Darzens reaction of phenacyl bromides with isatins both with N-alkyl groups and without N-substituent in the presence of potassium carbonate as a base catalyst ...
Qin Fu, Chao-Guo Yan
doaj   +1 more source

Unexpected chiral vicinal tetrasubstituted diamines via borylcopper-mediated homocoupling of isatin imines

Beilstein Journal of Organic Chemistry, 2022
Addressing the asymmetric synthesis of oxindole-based α-aminoboronic acids, instead of the expected products we disclosed the efficient homocoupling of oxindole-based N-tert-butanesulfinyl imines, with the generation of chiral, quaternary 1,2-diamines in
Marco Manenti, Leonardo Lo Presti, Giorgio Molteni, Alessandra Silvani   +3 more
doaj   +1 more source

Acid‐Controlled Regional Diverse Synthesis of CF₃‐Containing Ketoimines and Application in the Construction of Bispiro[oxindole‐pyrrolidine‐benzothiophenone]s [PDF]

, 2023
Shuo Sun, Danna Chen, Hai Guo, Yinghui Liu, Xia Liu, Wenjin Yan, Jinqi Huang   +6 more
openalex   +1 more source

Bioinspired Light‐Driven Organic Rotary Molecular Systems

ChemistryEurope, Volume 4, Issue 1, January 2026.
This review explores the evolution of bioinspired light‐driven rotary molecular systems (RMSs), highlighting the integration of natural chromophore‐based fragments to enhance quantum efficiency, photostability, and biocompatibility. Key strategies to optimize photochemical performance and broaden functional applications are discussed, providing a ...
Lidia Hortigüela, Sara P. Morcillo
wiley   +1 more source