Results 61 to 70 of about 8,623 (211)

Accessing Promising Passerini Adducts in Anticancer Drug Design

Molecules
The 3-component Passerini reaction (3CPR), discovered little more than 100 years ago, has been demonstrated in the last few decades to be a valuable tool for accessing structural diversity and complexity, essential topics to consider in drug discovery ...
Ana Margarida Janeiro, Aday González-Bakker, José M. Padrón, Carolina S. Marques   +3 more
doaj   +1 more source

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source

A Scalable and Sustainable Synthesis of Indirubin Frameworks Enabled by Deep Eutectic Solvents

ChemSusChem, Volume 19, Issue 1, January 2026.
A sustainable protocol for the synthesis of indirubin in a choline chloride/urea deep eutectic solvent at 70°C under air affords the product in 70% yield without chromatography. The method is robust, scalable to pilot scale, and enables late‐stage functionalization, granting access to a wide range of indirubin derivatives. CHEM21 green metrics validate
Biagio Delvecchio, Luciana Cicco, Andrea Nicola Paparella, Gaetano Di Salvo, Filippo Maria Perna, Vito Capriati   +5 more
wiley   +1 more source

Spiro[pyrrolidine-3,3′-oxindoles] and Their Indoline Analogues as New 5-HT6 Receptor Chemotypes

Molecules, 2017
Synthetic derivatives of spiro[pyrrolidinyl-3,3′-oxindole] alkaloids (coerulescine analogues) were investigated as new ligands for aminergic G-protein coupled receptors (GPCRs).
Ádám A. Kelemen, Grzegorz Satala, Andrzej J. Bojarski, György M. Keserű   +3 more
doaj   +1 more source

Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro‐Oxindole Dihydroquinazolinones as IRAP Inhibitors

ChemistryOpen, 2020
Insulin‐regulated aminopeptidase (IRAP) is a new potential macromolecular target for drugs aimed for treatment of cognitive disorders. Inhibition of IRAP by angiotensin IV (Ang IV) improves the memory and learning in rats.
Karin Engen, Dr. Sudarsana Reddy Vanga, Dr. Thomas Lundbäck, Dr. Faith Agalo, Vivek Konda, Dr. Annika Jenmalm Jensen, Prof. Johan Åqvist, Dr. Hugo Gutiérrez‐de‐Terán, Prof. Dr. Mathias Hallberg, Prof. Dr. Mats Larhed, Dr. Ulrika Rosenström   +10 more
doaj   +1 more source

Effective Low‐Temperature Oxidative Denitrogenation With Sulfated Titania Supported on Porous Carbon

Small Structures, Volume 7, Issue 1, January 2026.
We report the first synthesis of the novel S‐TiO2/C catalyst on highly porous pANI‐derived carbon. It achieved outstanding oxidative denitrogenation (ODN) performance, completing conversion of 1000 ppm indole in 60 min at 45°C. This is due to well‐dispersed S‐TiO2 facilitating H2O2 activation and •OH radical generation, and it proved highly reusable ...
Imteaz Ahmed, Minyoung Yoon, Sung Hwa Jhung   +2 more
wiley   +1 more source

Squaramide-Catalyzed Asymmetric Michael Addition/Cyclization Reaction for the Synthesis of Chiral Bisspiro Barbituric Acid–Oxindole Derivatives

Molecules
An efficient stereoselective strategy for the synthesis of chiral bisspiro barbituric acid–oxindole derivatives was developed. The asymmetric Michael addition/cyclization tandem reaction between benzylidene barbituric acids and oxindolylmalonitriles was ...
De-Jun Qiao, Da-Ming Du
doaj   +1 more source

The Traditional Chinese Medicine Compound Hezi Qingyou Formula Controls the MAPK Signaling Pathway for Alleviating Gastric Ulcer Induced by Acetic Acid in Rats

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
In clinical practice, Hezi Qingyou Formula (HZQYF) has been observed to effectively alleviate clinical symptoms associated with gastri ulcers, though its precise mechanism of action remains unclear. To investigate the effects of HZQYF on gastric ulcers, we established a rat model of gastric ulcer and examined its impact on ulcer area, pathological ...
Zhong Feng, Ruixia Wei, Junhao Tian, Hui Li, Haobo Chen, Yajie Hao, Meiyun Chen, Bingmei Su, Yuqian Lai, Mingjin Xun, Guimin Zhang, Meicun Yao, Poorani Gurumallesh   +12 more
wiley   +1 more source

Organocatalytic Access to Enantioenriched Spirooxindole-Based 4-Methyleneazetidines

Molecules, 2017
This work describes the synthesis of enantioenriched spiro compounds, incorporating the azetidine and the oxindole motifs. The preparation relies on a formal [2 + 2] annulation reaction of isatin-derived N-tert-butylsulfonyl ketimines with allenoates ...
Giulia Rainoldi, Matteo Faltracco, Claudia Spatti, Alessandra Silvani, Giordano Lesma   +4 more
doaj   +1 more source

Exploring Isophorone‐Based Dienones: Comprehensive Insights Into Their Synthesis, Reactivity, and Diverse Applications

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Isophorone is an important motif in synthetic organic chemistry, as it is highly reactive and can get involved in a diverse array of functional group transformations to access various synthetic intermediates and molecular targets. In this context, an important group of compounds is the conjugated or nonconjugated isophorone‐cored dienones, which are ...
M. Saeed Abaee, Mohammad M. Mojtahedi, Sohini Basu Roy   +2 more
wiley   +1 more source