Results 41 to 50 of about 2,987 (182)
Investigating the Antifungal Effects of Spirocyclopropane Oxindoles Derivatives Against Aspergillus Species [PDF]
Research in Molecular Medicine, 2023 Background: Given the increasing resistance of Aspergillus spp. to azoles, finding effective new compounds, such as the spirocyclopropane oxindoles (4a-4b-4c) derivatives, seems necessary.
Amirreza Ardebilifard +8 more
doaj
Stereodivergent propargylic alkylation of enals via cooperative NHC and copper catalysis
Nature Communications, 2022 The ability to construct multiple stereocenters in a modular fashion is an important goal of synthetic organic chemistry. Here the authors present a method to construct oxindoles in four stereoisomers with high enantioselectivity and diastereoselectivity
Yu-Hua Wen +4 more
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Angewandte Chemie, EarlyView.Die Kontrolle biologischer Systeme mit organischen Chromophoren hat sich zu einer vielversprechenden Strategie entwickelt und findet Anwendung von der chemischen Biologie bis hin zur Medizin. Die Komplexität von In‐vivo‐Systemen lässt sich jedoch nicht mit nur einer einzigen Lichtwellenlänge adäquat abbilden.
Nadja A. Simeth
wiley +1 more source
Journal of Saudi Chemical Society, 2018 This paper presents a synthetically challenging vicinal quaternary-tertiary C–C forming reaction of 3-substituted oxindoles and chalcones by a simple aryl substituted bifunctional thiourea catalyst.
Bin Wang +3 more
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Molecules, 2018 The use of readily available chiral trans-cyclohexanediamine-benzimidazole derivatives as bifunctional organocatalysts in the asymmetric electrophilic amination of unprotected 3-substituted oxindoles is presented. Different organocatalysts were evaluated;
Llorenç Benavent +2 more
doaj +1 more source
Frontiers in Neuroscience, 2018 Gut microbiota produces a wide and diverse array of metabolites that are an integral part of the host metabolome. The emergence of the gut microbiome-brain axis concept has prompted investigations on the role of gut microbiota dysbioses in the ...
Mathilde Jaglin +9 more
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Toward Chromoselective Transformations in Biological Systems: Perspectives and Challenges
Angewandte Chemie International Edition, EarlyView.Controlling biological systems with small‐molecule chromophores has evolved into a powerful strategy and is applied from chemical biology to medicine. However, the complexity of in vivo systems cannot be matched by a single wavelength of light. Developing methods to combine and individually control multiple chromophores is crucial.
Nadja A. Simeth
wiley +1 more source
An Expedient Synthesis of Oxindole Dimers by Direct Oxidative Dimerization of Oxindoles
Bulletin of the Korean Chemical Society, 2013 Oxindole dimers have been used as intermediates in the synthesis of various cyclotryptamine alkaloids. An efficient direct synthesis of oxindole dimers has been carried out from 3-substituted oxindoles via an oxidative dimerization using manganese(III) acetate or copper acetate/silver acetate system.
Hyun Ju Lee +3 more
openaire +2 more sources
Chemistry3,3-Dialkoxy-2-oxindoles are prevalent in natural products and exhibit unique biological activities. Among them, acyclic alkoxy analogues show instability in acidic conditions, making access to acyclic isatin ketals highly challenging.
Keisuke Tokushige +2 more
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Catalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an update
Beilstein Journal of Organic Chemistry, 2016 Oxindole scaffolds are prevalent in natural products and have been recognized as privileged substructures in new drug discovery. Several oxindole-containing compounds have advanced into clinical trials for the treatment of different diseases. Among these
Bin Yu +3 more
doaj +1 more source