Results 71 to 80 of about 60,467 (293)

Mrpl35, A Mitospecific Component of Mitoribosomes, Plays A Key Role in Cytochrome \u3cem\u3eC\u3c/em\u3e Oxidase Assembly [PDF]

, 2017
Mitoribosomes perform the synthesis of the core components of the oxidative phosphorylation (OXPHOS) system encoded by the mitochondrial genome.
Box, Jodie M, Kaur, Jasvinder, Stuart, Rosemary A.   +2 more
core   +1 more source

Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function

, 2018
Immune cell differentiation and function are crucially dependent on specific metabolic programs dictated by mitochondria, including the generation of ATP from the oxidation of nutrients and supplying precursors for the synthesis of macromolecules and ...
Pearce, E., Rambold, A.
core   +1 more source

TREM1/3 deficiency impairs tissue repair after acute kidney injury and mitochondrial metabolic flexibility in tubular epithelial cells [PDF]

, 2019
Long-term sequelae of acute kidney injury (AKI) are associated with incomplete recovery of renal function and the development of chronic kidney disease (CKD), which can be mediated by aberrant innate immune activation, mitochondrial pathology, and ...
Borrelli, Cristiana, Butter, Loes M, Claessen, Nike, Colonna, Marco, Dessing, Mark C, Florquin, Sandrine, Leemans, Jaklien C, Rampanelli, Elena, Scantlebery, Angelique M.L, Soriani, Alessandra, Tammaro, Alessandra   +10 more
core   +2 more sources

Drugging OXPHOS Dependency in Cancer [PDF]

Cancer Discovery, 2019
Abstract Researchers at The University of Texas MD Anderson Cancer Center in Houston are developing an inhibitor of oxidative phosphorylation, IACS-10759, that targets complex I of the mitochondrial electron transport chain. Ongoing early clinical studies indicate that IACS-10759 appears safe, tolerable, and active; the drug has also ...
openaire   +1 more source

NFS1 Regulates IDH2 to Attenuate Abdominal Aortic Aneurysms via Interacting With SP2

Advanced Science, EarlyView.
The loss of NFS1 leads to its reduced binding with the transcription factor SP2, resulting in decreased expression of the downstream gene Idh2. This causes a shift in energy supply toward glycolysis in VSMCs, ultimately contributing to the occurrence and progression of AAA.
Luzheng Zhang, Yu Zhang, Dezhong Wen, Suxiang Guo, Xiaohui Qi, Heng Wang, Yujin Sun, Guangdong Yang, Yuehong Wang, Song Xue   +9 more
wiley   +1 more source

Mitochondrial ataxia - Unravelling the puzzle

Annals of Movement Disorders
Primary mitochondrial diseases (PMDs) can be caused by a defect in any of the mitochondrial metabolic pathways, due to mitochondrial or nuclear DNA mutations, or occurring de novo. Ataxia is one of the most common presentations in mitochondrial disorders
Neha Pandita, Jacky Ganguly, Hrishikesh Kumar   +2 more
doaj   +1 more source

Attenuates of NAD+ impair BMSC osteogenesis and fracture repair through OXPHOS

Stem Cell Research & Therapy, 2022
Background Controlling the adipo-osteogenic lineage commitment of bone marrow mesenchymal stem cell (BMSC) in favor of osteogenesis is considered a promising approach for bone regeneration and repair.
Boer Li, Yu Shi, Mengyu Liu, Fanzi Wu, Xuchen Hu, Fanyuan Yu, Chenglin Wang, Ling Ye   +7 more
doaj   +1 more source

Parallel Structural Evolution of Mitochondrial Ribosomes and OXPHOS Complexes [PDF]

Genome Biology and Evolution, 2015
The five macromolecular complexes that jointly mediate oxidative phosphorylation (OXPHOS) in mitochondria consist of many more subunits than those of bacteria, yet, it remains unclear by which evolutionary mechanism(s) these novel subunits were recruited.
E. O. van der Sluis, H. Bauerschmitt, T. Becker, T. Mielke, J. Frauenfeld, O. Berninghausen, W. Neupert, J. M. Herrmann, R. Beckmann   +8 more
openaire   +5 more sources

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Mitochondria directly influence fertilisation outcome in the pig [PDF]

, 2006
The mitochondrion is explicitly involved in cytoplasmic regulation and is the cell's major generator of ATP. Our aim was to determine whether mitochondria alone could influence fertilisation outcome.
Abeydeera, Alves, Anderson, Barritt, Barritt, Barritt, Blok, Brenner, Cetica, Clayton, Cohen, Cohen, Cran, de Loos, Downs, Dumollard, Eisen, Emma C Spikings, Findlay, Fong, Hue, Jansen, Justin C St John, King, Koo, Krakauer, Larsson, Larsson, Li, Lin, Liu, Mach  ty, Marchington, Mariana Freitas, Marinos, McConnell, Michaels, Moyes, Park, Pik  , Poulton, Raghu, Reynier, Roca, Sathananthan, Shahinaz H El Shourbagy, Shea, Spelbrink, St John, St John, St John, St John, St. John, Stojkovic, Sun, Tessa, Tian, Trimarchi, Ursing, Van Blerkom, Van Blerkom, Van Blerkom, Wakayama, Wallace, Wilmut, Zamzami, Zernicka-Goetz   +66 more
core   +3 more sources