Results 61 to 70 of about 27,463 (211)

Caffeine preferentially protects against oxygen‐induced retinopathy

The FASEB Journal, 2017
ABSTRACT Retinopathy of prematurity (ROP) is the leading cause of childhood blindness, but current anti‐VEGF therapy is concerned with delayed retinal vasculature, eye, and brain development of preterm infants. The clinical observation of reduced ROP severity in premature infants after caffeine treatment for apnea
Shuya, Zhang, Rong, Zhou, Bo, Li, Haiyan, Li, Yanyan, Wang, Xuejiao, Gu, Lingyun, Tang, Cun, Wang, Dingjuan, Zhong, Yuanyuan, Ge, Yuqing, Huo, Jing, Lin, Xiao-Ling, Liu, Jiang-Fan, Chen   +13 more
openaire   +3 more sources

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Inhibition of Oxygen-Induced Retinopathy in RTP801-Deficient Mice

Investigative Opthalmology & Visual Science, 2004
Ischemic proliferative retinopathy, which occurs as a complication of diabetes mellitus, prematurity, or retinal vein occlusion, is a major cause of blindness worldwide. In addition to retinal neovascularization, it involves retinal degeneration, of which apoptosis is the main cause.
Anat, Brafman, Igor, Mett, Millicent, Shafir, Helen, Gottlieb, Golda, Damari, Sabrina, Gozlan-Kelner, Vicktoria, Vishnevskia-Dai, Rami, Skaliter, Paz, Einat, Alexander, Faerman, Elena, Feinstein, Tzipora, Shoshani   +11 more
openaire   +2 more sources

Lysosome Evanescence Mediates Autophagic Flux Impairment in Glucose Imbalanced Environments

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Schwann cells (SCs) support axonal function and promote nerve regeneration. This study investigated how various glucose concentrations influence SC viability, oxidative stress, and autophagy, which contribute to diabetic neuropathy. RSC96 SCs were cultured under five glucose conditions (0, 2.5, 5.5, 50, or 100 mM) for 24, 48, and 72 h.
Yuan‐Chen Cheng, Ling‐Li Chang, Hung‐Chen Wang, Wei‐Chun Hung, Chia‐Hua Hsieh, Yi‐Hsuan Wang, Kuang‐I Cheng   +6 more
wiley   +1 more source

The neurovascular relation in oxygen-induced retinopathy.

Molecular vision, 2009
Purpose: Longitudinal studies in rat models of retinopathy of prematurity (ROP) have demonstrated that abnormalities of retinal vasculature and function change hand-in-hand. In the developing retina, vascular and neural structures are under cooperative molecular control.
Akula, James, Mocko, Julie A., Benador, Ilan Y., Hansen, Ronald, Favazza, Tara L., Vyhovsky, Tanya C., Fulton, Anne   +6 more
openaire   +2 more sources

LPCAT3 as a Potential Drug Target for Ultraviolet Radiation–Induced Cataract: Insights From Multiomics Analysis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ultraviolet B (UVB) radiation is a major risk factor for cataract development, but the molecular mechanisms underlying this process, particularly the involvement of regulated cell death pathways such as ferroptosis, remain unclear. Transcriptomic, proteomic, and metabolomic analyses were performed on lens tissues from UVB‐induced cataract rat ...
Fei Xu, Xiao‐Bo Wan, Yong‐Shun Liang, Tian Lan, Hao Liang   +4 more
wiley   +1 more source

Accelerated oxygen-induced retinopathy is a reliable model of ischemia-induced retinal neovascularization.

PLoS ONE, 2017
Retinal ischemia and pathological angiogenesis cause severe impairment of sight. Oxygen-induced retinopathy (OIR) in young mice is widely used as a model to investigate the underlying pathological mechanisms and develop therapeutic interventions.
Pilar Villacampa, Katja E Menger, Laura Abelleira, Joana Ribeiro, Yanai Duran, Alexander J Smith, Robin R Ali, Ulrich F Luhmann, James W B Bainbridge   +8 more
doaj   +1 more source

N-CAM exhibits a regulatory function in pathological angiogenesis in oxygen induced retinopathy. [PDF]

PLoS ONE, 2011
Diabetic retinopathy and retinopathy of prematurity are diseases caused by pathological angiogenesis in the retina as a consequence of local hypoxia.
Joakim Håkansson, Anders Ståhlberg, Fredrik Wolfhagen Sand, Holger Gerhardt, Holger Gerhardt, Henrik Semb   +5 more
doaj   +1 more source

Recent progress on the development of hydrogel‐based microneedles for transdermal drug delivery

VIEW, EarlyView.
This study provides a comprehensive and up‐to‐date analysis of recent progress in HMN technology, covering fundamental transdermal delivery mechanisms and design principles, biomaterials used in HMN fabrication, drug loading and release strategies, and emerging therapeutic applications.
Mohammad Muhtasim Ittisaf, Salman Farsi Taharat, Md. Sadek Miah, Hasan Tasnim Salehin, M. Azam Ali, Shoeb Ahmed   +5 more
wiley   +1 more source

Chronic intermittent hypoxia disrupts protective microgliosis in ischemic proliferative retinopathy

Journal of Neuroinflammation
Sleep apnea that leads to chronic intermittent hypoxia (CIH) is an independent risk factor for advanced, debilitating ischemic proliferative retinopathies, such as diabetic retinopathy (DR) and retinopathy of prematurity (ROP).
Tianxiang Yang, Kaitryn E. Ronning, Sébastien Augustin, Frédéric Blond, Caroline Nous, Foteini Argyriou, Sara Touhami, Cécile Delarasse, Xavier Guillonneau, Florian Sennlaub   +9 more
doaj   +1 more source