Results 41 to 50 of about 4,357,227 (243)

Quantification of oxygen-induced retinopathy in the mouse. [PDF]

Investigative ophthalmology & visual science, 1997
To describe a quantifiable model of vascular proliferation in oxygen-induced retinopathy (OIR) in the mouse.Neonate Quackenbush mice were subjected to high-ambient oxygen (approximately 95%) for the first 5 days after birth, effecting a total inhibition of retinal vascular growth.
Browning, Jay, Wylie, Christine K., Gole, Glen   +2 more
openaire   +2 more sources

Oxygen-induced retinopathy: a model for vascular pathology in the retina [PDF]

Eye, 2009
Ischaemic vascular disease in the retina may either leave retina permanently ischaemic with slow degradation of vision, or alternatively lead to proliferative vascular disease, which can also destroy vision. To investigate the molecular and cellular mechanisms that contribute to this pathology a mouse model has been studied extensively.
A, Scott, M, Fruttiger
openaire   +2 more sources

Metabolism in Retinopathy of Prematurity

Life, 2021
Retinopathy of prematurity is defined as retinal abnormalities that occur during development as a consequence of disturbed oxygen conditions and nutrient supply after preterm birth.
Yohei Tomita, Ayumi Usui-Ouchi, Anders K. Nilsson, Jay Yang, Minji Ko, Ann Hellström, Zhongjie Fu   +6 more
doaj   +1 more source

The oxygen-induced retinopathy as an experimental model of retinopathy of prematurity

Ophthalmology Reports, 2013
The experimental model of retinopathy of prematurity was developed on the base of an oxygen-induced retinopathy in newborn. Wistar rats. This model was meant to investigate histopathological and functional manifestations of the disease. The study was performed on 60 newborn Wistar rats.
Olga Aleksandrovna Konikova, Vladimir Vsevolodovich Brzheskiy, Yelena Pavlovna Fedotova, Ruslan Abdulayevich Nasyrov   +3 more
openaire   +2 more sources

Stanniocalcin-1 is a Modifier of Oxygen-Induced Retinopathy Severity [PDF]

Current Eye Research, 2019
Purpose/Aim: Abnormal activation of signaling pathways related to angiogenesis, inflammation, and oxidative stress has been implicated in the pathophysiology of retinopathy of prematurity (ROP), a leading cause of blindness in pre-term infants. Therapies for ROP include laser and anti-vascular endothelial growth factor agents.
Lauren A. Dalvin, Mary Elizabeth Hartnett, Colin A. Bretz, Cheryl R. Hann, Ricky Z Cui, Alan D. Marmorstein, David Sheikh-Hamad, Michael P. Fautsch, Gavin W. Roddy   +8 more
openaire   +2 more sources

The immunoproteasome subunit LMP10 mediates angiotensin II-induced retinopathy in mice

Redox Biology, 2018
Inflammation has been implicated in a variety of retinal diseases. The immunoproteasome plays a critical role in controlling inflammatory responses, but whether activation of immunoproteasome contributes to angiotensin II (Ang II)-induced retinopathy ...
Shuai Wang, Jing Li, Jie Bai, Jing-Min Li, Yi-Lin Che, Qiu-Yue Lin, Yun-Long Zhang, Hui-Hua Li   +7 more
doaj   +1 more source

Leverage of nuclease-deficient CasX for preventing pathological angiogenesis

Molecular Therapy: Nucleic Acids, 2023
Gene editing with a CRISPR/Cas system is a novel potential strategy for treating human diseases. Pharmacological inhibition of phosphoinositide 3-kinase (PI3K) δ suppresses retinal angiogenesis in a mouse model of oxygen-induced retinopathy. Here we show
Haote Han, Yanhui Yang, Yunjuan Jiao, Hui Qi, Zhuo Han, Luping Wang, Lijun Dong, Jingkui Tian, Bart Vanhaesebroeck, Xiaopeng Li, Junwen Liu, Gaoen Ma, Hetian Lei   +12 more
doaj   +1 more source

Oxygen-induced retinopathy in the mouse. [PDF]

, 2018
PURPOSE: To develop oxygen-induced retinopathy in the mouse with reproducible and quantifiable proliferative retinal neovascularization suitable for examining pathogenesis and therapeutic intervention for retinal neovascularization in retinopathy of ...
McLellan, Angela, Kostyk, Sandra K., Wesolowski, Eva, D'Amato, Robert, Sullivan, Richard, D'Amore, Patricia, Smith, Lois   +6 more
core   +6 more sources

The influence of background diabetic retinopathy in the second eye on rates of progression of diabetic retinopathy between 2005 and 2010. [PDF]

, 2012
PURPOSE: The Gloucestershire Diabetic Eye Screening Programme offers annual digital photographic screening for diabetic retinopathy to a countywide population of people with diabetes.
Chave, Steve J., Mark Histed, Stratton, IM, Histed, Mark, Scanlon, Peter H., Chave, SJ, Peter H. Scanlon, Histed, M, Stephen J. Aldington, Aldington, Stephen J., Scanlon, PH, Stratton, Irene M., Irene M. Stratton, Steve J. Chave, Aldington, SJ, Scanlon, Peter H, Scanlon, Peter   +16 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source