Results 21 to 30 of about 27,463 (211)

Intraocular injection of KH902 alleviates retinal hypoxia in a mouse model of oxygen-induced retinopathy [PDF]

Archives of Biological Sciences, 2021
Inhibition of vascular endothelial growth factor (VEGF) has been widely applied in anti-neovascularization therapies. As a novel anti-VEGF agent, KH902 (conbercept) is designed to restrain pathological angiogenesis.
Yang Ning, He Xuejun, Zhang Ningzhi, Xing Yiqiao   +3 more
doaj   +1 more source

Multi-color Flow Cytometry Protocol to Characterize Myeloid Cells in Mouse Retina Research

Bio-Protocol, 2023
Myeloid cells, specifically microglia and macrophages, are activated in retinal diseases and can improve or worsen retinopathy outcomes based on their inflammatory phenotype.
Wei Xiao, RAMI A. Shahror, Carol Morris, Ruth Caldwell, Abdelrahman Fouda   +4 more
doaj   +1 more source

Perbandingan Hispatologi Neovascular Tuft pada Retina Tikus yang Mengalami Oxygen-Induced Retinopathy dengan dan tanpa Pemberian L-Carnitine

Majalah Kedokteran Bandung, 2018
Retinopathy of prematurity (ROP) adalah salah satu penyebab kebutaan pada anak. Metode oxygen-induced retinopathy (OIR) pada tikus, menilai patogenesis dan terapi neovaskularisasi retina pada ROP.
Raihana Rustam, Kemala Sayuti, Hendriati Hendriati   +2 more
doaj   +1 more source

Graphene quantum dots rescue angiogenic retinopathy via blocking STAT3/Periostin/ERK signaling

Journal of Nanobiotechnology, 2022
Background Pathological retinal angiogenesis resulting from a variety of ocular diseases including oxygen induced retinopathy, diabetic retinopathy and ocular vein occlusion, is one of the major reasons for vision loss, yet the therapeutic option is ...
Na Zhao, Xiao Gui, Qian Fang, Rui Zhang, Weiye Zhu, Haorui Zhang, Qing Li, Yukun Zhou, Jiawei Zhao, Xiao Cui, Guangping Gao, Huipeng Tang, Ni Shen, Taoyong Chen, Hongyuan Song, Wei Shen   +15 more
doaj   +1 more source

OXYGEN INDUCED RETINOPATHY: THE KITTEN MODEL RE–EXAMINED [PDF]

Australian Journal of Opthalmology, 1982
AbstractWe have studied the kitten model of oxygen induced retinopathy by the technique of corrosion vascular casting/scanning electron microscopy. The predominant morphological features of the kitten model are preretinal and intraretinal neovascularization with a minor component of arteriovenous shunting.
Gole, GA, Gannon, BJ, Goodger, AM
openaire   +5 more sources

Exosomes from Microglia Attenuate Photoreceptor Injury and Neovascularization in an Animal Model of Retinopathy of Prematurity

Molecular Therapy: Nucleic Acids, 2019
The role of microglia in the pathophysiology of ischemic retinal diseases has been studied extensively. Exosomes from microglial cells exert protective effects during several nervous system diseases, but their roles in hypoxia-induced retinopathy remain ...
Wenqin Xu, Ying Wu, Zhicha Hu, Lijuan Sun, Guorui Dou, Zifeng Zhang, Haiyang Wang, Changmei Guo, Yusheng Wang   +8 more
doaj   +1 more source

Ocular coherence tomography image data of the retinal laminar structure in a mouse model of oxygen-induced retinopathy

Data in Brief, 2017
The data presented in this article are related to the research paper entitled “Norrin treatment improves ganglion cell survival in an oxygen-induced model of retinal ischemia” (Dailey et al., 2017) [1] This article describes treatment with the human ...
Wendy A. Dailey, Kimberly A. Drenser, Sui Chien Wong, Mei Cheng, Joseph Vercellone, Kevin K. Roumayah, Erin V. Feeney, Mrinalini Deshpande, Alvaro E. Guzman, Michael Trese, Kenneth P. Mitton   +10 more
doaj   +1 more source

Identification of altered microRNAs in retinas of mice with oxygen-induced retinopathy [PDF]

International Journal of Ophthalmology, 2019
AIM: To identify disease-related miRNAs in retinas of mice with oxygen-induced retinopathy (OIR), and to explore their potential roles in retinal pathological neovascularization.
Lu-Si Zhang, Ye-Di Zhou, Ying-Qian Peng, Hui-Lan Zeng, Shigeo Yoshida, Tan-Tai Zhao   +5 more
doaj   +1 more source

Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy. [PDF]

PLoS ONE, 2014
Proliferative retinopathy is a leading cause of blindness, including retinopathy of prematurity (ROP) in children and diabetic retinopathy in adults. Retinopathy is characterized by an initial phase of vessel loss, leading to tissue ischemia and hypoxia,
Shaday Michan, Aimee M Juan, Christian G Hurst, Zhenghao Cui, Lucy P Evans, Colman J Hatton, Dorothy T Pei, Meihua Ju, David A Sinclair, Lois E H Smith, Jing Chen   +10 more
doaj   +1 more source

Dexamethasone Reduces Oxygen Induced Retinopathy in a Mouse Model [PDF]

Pediatric Research, 1999
Dexamethasone is widely used in the postnatal period. Its impact on retinopathy of prematurity (ROP) is extremely controversial; published studies have found a detrimental, protective, or no effect on ROP. The goal of this study was to test the hypothesis that use of dexamethasone during the injury phase (oxygen exposure) reduces the severity of oxygen-
T, Rotschild, B N, Nandgaonkar, K, Yu, R D, Higgins   +3 more
openaire   +2 more sources