Exploration of Oxygen-Induced Retinopathy Model to Discover New Therapeutic Drug Targets in Retinopathies [PDF]
Frontiers in Pharmacology, 2020 Oxygen-induced retinopathy (OIR) is a pure hypoxia-driven angiogenesis model and the most widely used model for ischemic retinopathies, such as retinopathy of prematurity (ROP), proliferative diabetic retinopathy (PDR), and retinal vein occlusion (RVO ...
Maria Vähätupa +4 more
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Amelioration of oxygen-induced retinopathy in neonatal mice with fetal growth restriction [PDF]
Frontiers in Cell and Developmental BiologyIntroduction: With the aim of optimizing the balance of maintaining a safe oxygen saturation and reducing the risk of retinopathy of prematurity in human neonates with fetal growth restriction (FGR), the present study investigated the distinct effects of
Ryusuke Watanabe +10 more
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Expression of the neuroprotective factors BDNF, CNTF, and FGF-2 in normal and oxygen induced retinopathy [PDF]
Frontiers in Neuroscience, 2022 IntroductionOxygen-induced retinopathy is a type of retinal pathological neovascularization (NV) disease that leads to vision loss and translates to a significant societal cost.
Jifu Xin +3 more
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Revisiting the mouse model of oxygen-induced retinopathy
Eye and Brain, 2016 Clifford B Kim,1,2 Patricia A D’Amore,2–4 Kip M Connor1,2 1Angiogenesis Laboratory, Massachusetts Eye and Ear, 2Department of Ophthalmology, Harvard Medical School, 3Schepens Eye Research Institute, Massachusetts Eye and Ear, 4Department of ...
Kim CB, D'Amore PA, Connor KM
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Identification of reference genes for the normalization of retinal mRNA expression by RT-qPCR in oxygen induced retinopathy, anemia, and erythropoietin administration [PDF]
PLoS ONE, 2023 Background Anemia and retinopathy of prematurity (ROP) are common comorbidities experienced by preterm infants, yet the role of anemia on the pathogenesis of ROP remains unclear. Reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR) is a
Mandkhai Molomjamts +1 more
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Metabolomics Analyses of Mouse Retinas in Oxygen-Induced Retinopathy. [PDF]
Invest Ophthalmol Vis Sci, 2021 Retinal neovascularization is a severe pathological process leading to irreversible blindness. This study aims to identify the altered metabolites and their related pathways that are involved in retinal neovascularization.To reveal the global metabolomic profile change in the retinal neovascularization process, an untargeted metabolomics analysis of ...
Zhou Y +7 more
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670nm photobiomodulation as a novel protection against retinopathy of prematurity: evidence from oxygen induced retinopathy models. [PDF]
PLoS ONE, 2013 IntroductionTo investigate the validity of using 670nm red light as a preventative treatment for Retinopathy of Prematurity in two animal models of oxygen-induced retinopathy (OIR).Materials and methodsDuring and post exposure to hyperoxia, C57BL/6J mice
Riccardo Natoli +6 more
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Long–Term Impairment of Retinal Ganglion Cell Function After Oxygen–Induced Retinopathy [PDF]
CellsPremature infants with retinopathy of prematurity (ROP) have neovascularization of the retina, potentially resulting in low vision and even blindness. Some of these infants still have visual impairment, even if ROP resolves as they age.
Adam M. Schmitz +3 more
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The Protective Effects of Endogenous PACAP in Oxygen-Induced Retinopathy. [PDF]
J Mol Neurosci, 2021 Abstract Pituitary adenylate cyclase–activating polypeptide (PACAP) is a neuropeptide having trophic and protective functions in neural tissues, including the retina. Previously, we have shown that intravitreal PACAP administration can maintain retinal structure in the animal model of retinopathy of prematurity (ROP).
Kvarik T +10 more
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Targeting VEGF in canine oxygen-induced retinopathy - a model for human retinopathy of prematurity
Eye and Brain, 2016 D Scott McLeod, Gerard A Lutty Department of Ophthalmology, Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, MD, USA Abstract: Development of the dog superficial retinal vasculature is similar to the mechanism of human retinal ...
McLeod DS, Lutty GA
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