Maternally expressed gene 3 regulates retinal neovascularization in retinopathy of prematurity
Neural Regeneration Research, 2022 The mouse model of oxygen induced retinopathy is suitable for the study of various retinal neovascularization diseases, including retinopathy of prematurity.
Yu Di +5 more
doaj +1 more source
An imbalance in autophagy contributes to retinal damage in a rat model of oxygen-induced retinopathy. [PDF]
J Cell Mol Med, 2021 Pesce NA +7 more
europepmc +2 more sources
Neural Regeneration Research, 2021 Whether long non-coding RNA myocardial infarction-associated transcript is involved in oxygen-induced retinopathy remains poorly understood. To validate this hypothesis, we established a newborn mouse model of oxygen-induced retinopathy by feeding in an ...
Yu Di, Yue Wang, Xue Wang, Qing-Zhu Nie
doaj +1 more source
Hyperoxia Inhibits Proliferation of Retinal Endothelial Cells in a Myc-Dependent Manner
Life, 2021 Oxygen supplementation is necessary to prevent mortality in severely premature infants. However, the supraphysiological concentration of oxygen utilized in these infants simultaneously creates retinovascular growth attenuation and vasoobliteration that ...
Charandeep Singh +5 more
doaj +1 more source
Matrix metalloproteinase-9 and vascular endothelial growth factor expression change in experimental retinal neovascularization [PDF]
International Journal of Ophthalmology, 2016 AIM: To investigate the signal transduction mechanism of matrix metalloproteinase-9 (MMP-9) mediated- vascular endothelial growth factor (VEGF) expression and retinal neovascularization (RNV) in oxygen-induced retinopathy (OIR) model.
Yu Di, Qing-Zhu Nie, Xiao-Long Chen
doaj +1 more source
Indomethacin Improves Oxygen-Induced Retinopathy in the Mouse [PDF]
Pediatric Research, 1999 Retinopathy of prematurity is a disease commonly affecting extremely premature babies. Indomethacin is widely used in the perinatal period. The goal of the present study was to test the hypothesis that indomethacin will improve retinopathy in a mouse model when administered during the period of injury (hyperoxia exposure) to the developing retinal ...
B N, Nandgaonkar +3 more
openaire +2 more sources
Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin
eLife, 2020 Edema stemming from leaky blood vessels is common in eye diseases such as age-related macular degeneration and diabetic retinopathy. Whereas therapies targeting vascular endothelial growth factor A (VEGFA) can suppress leakage, side-effects include ...
Ross O Smith +7 more
doaj +1 more source
Advanced Science, 2022 Retinopathy of prematurity (ROP) is one of the leading causes of childhood visual impairment and blindness. However, there are still very few effective pharmacological interventions for ROP.
Jie Ran +13 more
doaj +1 more source
The progress of prophylactic treatment in retinopathy of prematurity [PDF]
International Journal of Ophthalmology, 2018 Retinopathy of prematurity (ROP) is a retinal vascular disorder frequently found in premature infants. Different therapeutic strategies have been developed to treat ROP.
Hong-Bing Zhang +3 more
doaj +1 more source
Acetylcholinesterase inhibition ameliorates retinal neovascularization and glial activation in oxygen-induced retinopathy [PDF]
International Journal of Ophthalmology, 2020 AIM: To investigate whether inhibition of acetylcholinesterase (AChE) by donepezil ameliorate aberrant retinal neovascularization (RNV) and abnormal glial activation in oxygen-induced retinopathy (OIR).
Qiu-Ping Liu +4 more
doaj +1 more source