Results 31 to 40 of about 4,357,227 (243)

Delay in diabetic retinopathy screening increases the rate of detection of referable diabetic retinopathy. [PDF]

, 2013
AIMS: To assess whether there is a relationship between delay in retinopathy screening after diagnosis of type 2 diabetes and level of retinopathy detected.
Stratton, I. M., Scanlon, PH, Stratton, IM, Scanlon, P.H., Aldington, S. J., Stratton, I.M., Aldington, S.J., Aldington, SJ, Scanlon, Peter H   +8 more
core   +1 more source

Metabolomics Analyses of Mouse Retinas in Oxygen-Induced Retinopathy

Investigative Opthalmology & Visual Science, 2021
Retinal neovascularization is a severe pathological process leading to irreversible blindness. This study aims to identify the altered metabolites and their related pathways that are involved in retinal neovascularization.To reveal the global metabolomic profile change in the retinal neovascularization process, an untargeted metabolomics analysis of ...
Zhou, Yedi, Tan, Wei, Zou, Jingling, Cao, Jian, Huang, Qian, Jiang, Bing, Yoshida, Shigeo, Li, Yun   +7 more
openaire   +2 more sources

Exosomes from Microglia Attenuate Photoreceptor Injury and Neovascularization in an Animal Model of Retinopathy of Prematurity

Molecular Therapy: Nucleic Acids, 2019
The role of microglia in the pathophysiology of ischemic retinal diseases has been studied extensively. Exosomes from microglial cells exert protective effects during several nervous system diseases, but their roles in hypoxia-induced retinopathy remain ...
Wenqin Xu, Ying Wu, Zhicha Hu, Lijuan Sun, Guorui Dou, Zifeng Zhang, Haiyang Wang, Changmei Guo, Yusheng Wang   +8 more
doaj   +1 more source

Oxygen-Induced Retinopathy: Lack of Adverse Heparin Effect [PDF]

Pediatric Research, 1990
Retinopathy of prematurity is a disorder of abnormal retinal vascular proliferation, and one hypothesis for its pathogenesis involves abnormal activity of angiogenic growth factors in the retina. One of these, acidic fibroblast growth factor, is found primarily in retina and brain tissues. Its mitogenic effect is greatly potentiated in vitro by heparin.
R D, Higgins, D L, Phelps
openaire   +2 more sources

TLR2 signaling contributes to the angiogenesis of oxygen-induced retinopathy

Experimental Eye Research, 2021
To evaluate the role of Toll-like receptor 2 (TLR2) signaling in retinal neovascularization in a mouse model of oxygen-induced retinopathy (OIR).The OIR model was established in C57BL/6J wild type (WT) mice and TLR2-/- mice. Retinal neovascularization in the OIR model was measured by counting new vascular cell nuclei above the internal limiting ...
Yuying, Sun, Yao, Ni, Ning, Kong, Chunyu, Huang   +3 more
openaire   +2 more sources

Assessment of retinopathy [PDF]

, 2010
Warren Gillibrand and Phil Holdich explain the importance of screening all patients with diabetes annually for retinopathy as in the majority of cases effective treatment can be given to maintain visual ...
Holdich, Phil, Gillibrand, Warren P.
core   +4 more sources

Ocular coherence tomography image data of the retinal laminar structure in a mouse model of oxygen-induced retinopathy

Data in Brief, 2017
The data presented in this article are related to the research paper entitled “Norrin treatment improves ganglion cell survival in an oxygen-induced model of retinal ischemia” (Dailey et al., 2017) [1] This article describes treatment with the human ...
Wendy A. Dailey, Kimberly A. Drenser, Sui Chien Wong, Mei Cheng, Joseph Vercellone, Kevin K. Roumayah, Erin V. Feeney, Mrinalini Deshpande, Alvaro E. Guzman, Michael Trese, Kenneth P. Mitton   +10 more
doaj   +1 more source

Genetic Influences on Susceptibility to Oxygen-Induced Retinopathy

Investigative Opthalmology & Visual Science, 2007
To investigate the inheritance of susceptibility to oxygen-induced retinopathy in the rat with the use of formal backcross analysis.Neonatal offspring of inbred albino Fischer 344 (F344) and pigmented Dark Agouti (DA) crosses and F1xF344 and F1xDA backcrosses were exposed to alternating 24-hour cycles of hyperoxia (80% oxygen in air) and normoxia (21 ...
van Wijngaarden, Peter, Brereton, Helen Mary, Coster, Douglas John, Williams, Keryn Anne   +3 more
openaire   +3 more sources

Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy. [PDF]

PLoS ONE, 2014
Proliferative retinopathy is a leading cause of blindness, including retinopathy of prematurity (ROP) in children and diabetic retinopathy in adults. Retinopathy is characterized by an initial phase of vessel loss, leading to tissue ischemia and hypoxia,
Shaday Michan, Aimee M Juan, Christian G Hurst, Zhenghao Cui, Lucy P Evans, Colman J Hatton, Dorothy T Pei, Meihua Ju, David A Sinclair, Lois E H Smith, Jing Chen   +10 more
doaj   +1 more source

Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis

Nature Communications, 2017
The local immune responses in the eye are attenuated to preserve sight. Surprisingly, Deliyanti et al. show that regulatory T cells (Tregs) take an active role in protecting the eye from neovascularization in oxygen-induced retinopathy, and that ...
Devy Deliyanti, Dean M. Talia, Tong Zhu, Mhairi J. Maxwell, Alex Agrotis, Jack R. Jerome, Emily M. Hargreaves, Steven Gerondakis, Margaret L. Hibbs, Fabienne Mackay, Jennifer L. Wilkinson-Berka   +10 more
doaj   +1 more source