Results 51 to 60 of about 4,357,227 (243)

Grading fluorescein angiograms in malarial retinopathy [PDF]

, 2015
This work was funded by The Wellcome Trust (IJCM, SPH, NAVB, MEM, DP, SoL: Grant No. 092668/Z/10/Z; Core Grant No. 084679/Z/08/Z).Background: Malarial retinopathy is an important finding in Plasmodium falciparum cerebral malaria, since it strengthens ...
Malcolm E. Molyneux, Molyneux, Malcolm E, Harding, Simon P, Maude, Richard J., Dhillon, Baljean, Ian J. C. MacCormick, Beare, Nicholas A. V., Beare, Nicholas A V, Simon Glover, Leach, Sophie, Lewallen, Susan, MacCormick, Ian J C, Molyneux, Malcolm E., Nicholas A. V. Beare, David Parry, Sophie Leach, Susan Lewallen, Glover, Simon, Simon P. Harding, MacCormick, Ian JC, Shyamanga Borooah, Borooah, Shyamanga, Harding, Simon P., Richard J. Maude, Parry, David, MacCormick, Ian J. C., Baljean Dhillon, Maude, Richard J, Beare, Nicholas AV, Glover, Simon James   +29 more
core   +1 more source

Genome editing abrogates angiogenesis in vivo

Nature Communications, 2017
Abnormal angiogenesis causes many ocular diseases. Here the authors employ CRISPR/Cas9 gene editing technology to silence VEGFR2, a major regulator of angiogenesis, in retinal endothelium and abrogate angiogenesis in the mouse models of oxygen-induced ...
Xionggao Huang, Guohong Zhou, Wenyi Wu, Yajian Duan, Gaoen Ma, Jingyuan Song, Ru Xiao, Luk Vandenberghe, Feng Zhang, Patricia A. D’Amore, Hetian Lei   +10 more
doaj   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Diabetic retinopathy at diagnosis of type 2 diabetes in Scotland [PDF]

, 2012
The prevalence of retinopathy at first screening is lower than in previous UK studies, consistent with earlier diagnosis of diabetes. Most newly diagnosed type 2 diabetic patients in Scotland are screened within an acceptable interval and the prevalence ...
Lee, N, Colhoun, H.M., H. C. Looker, Colhoun, H. M., M. Black, Sattar, N, Olson, J.A., Morris, A D, Olson, J. A., Philip, Sam, J. A. Olson, S. H. Wild, Olson, J A, Black, M., S. O. Nyangoma, Leese, G P, Doig, J, H. M. Colhoun, Looker, H C, Doig, J., ?, ?, J. A. McKnight, Nyangoma, S. O., Lindsay, R. S., null null, Nyangoma, S O, Lindsay, R S, Colhoun, H M, McKnight, J A, Leese, G.P., Black, M, Wild, S H, D. Cromie, Sattar, N., Cromie, D., Wild, S.H., A. D. Morris, Scottish Diabetic Retinopathy Screening Collaborative, McKnight, J. A., Morris, A.D., Lindsay, R.S., Leese, G. P., Morris, Andrew, Lee, N., G. P. Leese, N. Sattar, N. Lee, Cromie, D, Wild, S. H.; id_orcid, Looker, H. C., R. S. Lindsay, McKnight, J.A., J. Doig, Nyangoma, S.O., Philip, S., S. Philip, Looker, H.C.   +56 more
core   +1 more source

Coenzyme Q10 and Fish Oil Supplementation for Reducing Retinal Oxidative Stress in a Rat Model

Vision, 2023
Extremely low gestational-age neonates requiring supplemental oxygen experience intermittent hypoxia (IH) episodes, which predispose them to oxidative stress and retinopathy of prematurity.
Faisal Siddiqui, Charles Cai, Jacob V. Aranda, Kay D. Beharry   +3 more
doaj   +1 more source

Dexamethasone Reduces Oxygen Induced Retinopathy in a Mouse Model [PDF]

Pediatric Research, 1999
Dexamethasone is widely used in the postnatal period. Its impact on retinopathy of prematurity (ROP) is extremely controversial; published studies have found a detrimental, protective, or no effect on ROP. The goal of this study was to test the hypothesis that use of dexamethasone during the injury phase (oxygen exposure) reduces the severity of oxygen-
T, Rotschild, B N, Nandgaonkar, K, Yu, R D, Higgins   +3 more
openaire   +2 more sources

Multifunctional Manganese Oxide Nanocomposite Hydrogel With Synergistic Reactive Oxygen Species‐Scavenging, Oxygen‐Generating, Immunomodulatory, and Photothermal Antimicrobial Activities for Enhanced Diabetic Wound Healing

Advanced Science, EarlyView.
CFP/PC@MnO2 hydrogel integrates ROS scavenging, oxygen delivery, oxidative stress reduction, immunomodulation, and photothermal antibacterial properties. The incorporation of PC@MnO2 NPs endows the hydrogel with multiple functional advantages tailored to the pathological microenvironment of diabetic wounds, including efficient ROS clearance, mitigation
Zhi Xu, Xiaodong Luo, Jingxian Wu, Chaoyang Huang, Zhuoying Yang, Yixiang HePeng, Bosong Zhou, Xiang Li, Ruiyuan Liu, Xu Wu   +9 more
wiley   +1 more source

Stabilization of the retinal vascular network by reciprocal feedback between blood vessels and astrocytes [PDF]

, 2005
Development of the retinal vasculature is controlled by a hierarchy of interactions among retinal neurons, astrocytes and blood vessels. Retinal neurons release platelet-derived growth factor (PDGFA) to stimulate proliferation of astrocytes, which in ...
Heloise West, Richardson, WD, West, H, William D. Richardson, Fruttiger, M, Marcus Fruttiger   +5 more
core   +1 more source

Druggable Mendelian randomization prioritizes CDH2 and supports finerenone as a candidate therapeutic strategy for diabetic retinopathy

Frontiers in Pharmacology
Diabetic retinopathy remains a major cause of vision loss, and therapeutic strategies beyond anti-vascular endothelial growth factor treatment are still needed. This study aimed to identify genetically supported druggable targets for diabetic retinopathy
Xiangyang Liu, Ning Zhang, Shi Wu, Man Zhang, Bei Sun, Liming Chen   +5 more
doaj   +1 more source

Adenosine A2A receptor antagonists act at the hyperoxic phase to confer protection against retinopathy

Molecular Medicine, 2018
Background Retinopathy of prematurity (ROP) remains a major cause of childhood blindness and current laser photocoagulation and anti-VEGF antibody treatments are associated with reduced peripheral vision and possible delayed development of retinal ...
Rong Zhou, Shuya Zhang, Xuejiao Gu, Yuanyuan Ge, Dingjuan Zhong, Yuling Zhou, Lingyun Tang, Xiao-Ling Liu, Jiang-Fan Chen   +8 more
doaj   +1 more source