Results 1 to 10 of about 13,275 (143)

Cofactor-independent C–C bond cleavage reactions catalyzed by the AlpJ family of oxygenases in atypical angucycline biosynthesis [PDF]

Beilstein Journal of Organic Chemistry
Biosynthesis of atypical angucyclines involves unique oxidative B-ring cleavage and rearrangement reactions, which are catalyzed by AlpJ-family oxygenases, including AlpJ, JadG, and GilOII.
Jinmin Gao, Liyuan Li, Shijie Shen, Guomin Ai, Bin Wang, Fang Guo, Tongjian Yang, Hui Han, Zhengren Xu, Guohui Pan, Keqiang Fan   +10 more
doaj   +2 more sources

Heme Oxygenase-Like Metalloenzymes. [PDF]

Annu Rev Biochem
Heme oxygenase (HO)-like metalloenzymes are an emerging protein superfamily diverse in reaction outcome and mechanism. Found primarily in bacterial biosynthetic pathways, members conserve a flexible protein scaffold shared with the heme catabolic enzyme, HO, and a set of metal-binding residues.
Pope SR, McBride MJ, Nair MA, Salas-Solá XE, Krebs C, Bollinger JM, Boal AK.   +6 more
europepmc   +4 more sources

Eicosanoids in inflammation in the blood and the vessel

Frontiers in Pharmacology, 2022
Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids in cells. PUFAs regulate cellular function through the formation of derived lipid mediators termed eicosanoids.
Adriana Yamaguchi, Eliana Botta, Michael Holinstat, Michael Holinstat   +3 more
doaj   +1 more source

Rubber oxygenases [PDF]

Applied Microbiology and Biotechnology, 2018
Natural rubber (NR), poly(cis-1,4-isoprene), is used in an industrial scale for more than 100 years. Most of the NR-derived materials are released to the environment as waste or by abrasion of small particles from our tires. Furthermore, compounds with isoprene units in their molecular structures are part of many biomolecules such as terpenoids and ...
Dieter Jendrossek, Jakob Birke
openaire   +2 more sources

Structure Elucidation and Biochemical Characterization of Environmentally Relevant Novel Extradiol Dioxygenases Discovered by a Functional Metagenomics Approach

mSystems, 2019
The release of synthetic chemical pollutants in the environment is posing serious health risks. Enzymes, including oxygenases, play a crucial role in xenobiotic degradation. In the present study, we employed a functional metagenomics approach to overcome
Chandni Sidhu, Vipul Solanki, Anil Kumar Pinnaka, Krishan Gopal Thakur   +3 more
doaj   +3 more sources

Characterization and Function Analysis of the Beta-Carotene Oxygenase-like Genes in Carotenoids Metabolism of the Ridgetail White Prawn Exopalaemon carinicauda

Frontiers in Physiology, 2020
Carotenoids are almost universally distributed in living organisms. The oxidative metabolism by carotene oxygenase contributes to the metabolic processes of carotenoids.
Yue Jin, Yue Jin, Yue Jin, Yang Yu, Yang Yu, Yang Yu, Chengsong Zhang, Chengsong Zhang, Chengsong Zhang, Shihao Li, Shihao Li, Shihao Li, Xiaojun Zhang, Xiaojun Zhang, Xiaojun Zhang, Fuhua Li, Fuhua Li, Fuhua Li, Fuhua Li   +18 more
doaj   +1 more source

Identification of Disease-Related 2-Oxoglutarate/Fe (II)-Dependent Oxygenase Based on Reduced Amino Acid Cluster Strategy

Frontiers in Cell and Developmental Biology, 2021
The 2-oxoglutarate/Fe (II)-dependent (2OG) oxygenase superfamily is mainly responsible for protein modification, nucleic acid repair and/or modification, and fatty acid metabolism and plays important roles in cancer, cardiovascular disease, and other ...
Jian Zhou, Suling Bo, Hao Wang, Lei Zheng, Pengfei Liang, Yongchun Zuo   +5 more
doaj   +1 more source

Transcriptomic Analysis of Rhodococcus opacus R7 Grown on o-Xylene by RNA-Seq

Frontiers in Microbiology, 2020
Xylenes are considered one of the most common hazardous sources of environmental contamination. The biodegradation of these compounds has been often reported, rarer the ability to oxidize the ortho-isomer.
Jessica Zampolli, Alessandra Di Canito, Andrea Manconi, Luciano Milanesi, Patrizia Di Gennaro, Alessandro Orro   +5 more
doaj   +1 more source

The functional differentiation of the post-PKS tailoring oxygenases contributed to the chemical diversities of atypical angucyclines

Synthetic and Systems Biotechnology, 2018
Angucyclines are one of the largest families of aromatic polyketides with various chemical structures and bioactivities. Decades of studies have made it easy for us to depict the picture of their early biosynthetic pathways.
Keqiang Fan, Qian Zhang
doaj   +1 more source

Oxidative modification of free-standing amino acids by Fe(II)/αKG-dependent oxygenases

Engineering Microbiology, 2023
Fe(II)/α-ketoglutarate (αKG)-dependent oxygenases catalyze the oxidative modification of various molecules, from DNA, RNA, and proteins to primary and secondary metabolites.
Hui Tao, Ikuro Abe
doaj   +1 more source