Results 221 to 230 of about 80,657 (231)

Mechanism of O2 Activation by α-Ketoglutarate Dependent Oxygenases Revisited. A Quantum Chemical Study.

Journal of Physical Chemistry A, 2016
Four mechanisms previously proposed for dioxygen activation catalyzed by α-keto acid dependent oxygenases (α-KAO) were studied with dispersion-corrected DFT methods employing B3LYP and TPSSh functionals in combination with triple-ζ basis set (cc-pVTZ ...
A. Wójcik, M. Radoń, T. Borowski
semanticscholar   +1 more source

Engineering Rieske Non-Heme Iron Oxygenases for the Asymmetric Dihydroxylation of Alkenes.

Angewandte Chemie, 2015
The asymmetric dihydroxylation of olefins is of special interest due to the facile transformation of the chiral diol products into valuable derivatives. Rieske non-heme iron oxygenases (ROs) represent promising biocatalysts for this reaction as they can ...
Christine Gally, B. Nestl, B. Hauer
semanticscholar   +1 more source

CHAPTER 1:Biochemical Diversity of 2-Oxoglutarate-Dependent Oxygenases

, 2015
This chapter summarizes the diverse array of biochemical transformations that are catalysed by Fe(ii)- and 2-oxoglutarate (2OG)-dependent oxygenases. One group of these enzymes utilizes protein substrates and functions in structural stabilization, oxygen
R. Hausinger
semanticscholar   +1 more source

Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases.

Chemical Communications, 2015
There is interest in developing potent, selective, and cell-permeable inhibitors of human ferrous iron and 2-oxoglutarate (2OG) oxygenases for use in functional and target validation studies.
Cyrille C. Thinnes, A. Tumber, A. Tumber, C. Yapp, C. Yapp, G. Scozzafava, G. Scozzafava, Tzu-Lan Yeh, M. Chan, T. Tran, Kuo-Feng Hsu, Hanna Tarhonskaya, L. Walport, Sarah E Wilkins, Elisabeth D. Martinez, S. Müller, S. Müller, C. Pugh, P. Ratcliffe, P. Brennan, P. Brennan, A. Kawamura, A. Kawamura, C. Schofield   +23 more
semanticscholar   +1 more source

Mechanisms of 2-oxoglutarate-dependent oxygenases: The hydroxylation paradigm and beyond

, 2015
In humans, Fe(ii)- and 2-oxoglutarate-dependent (Fe/2OG) oxygenases are generally of the dioxygenase subclass and mediate hydroxylation of unactivated aliphatic carbon centres.
J. M. Bollinger, Jr., Wei‐chen Chang, Megan L. Matthews, Ryan J. Martinie, A. Boal, C. Krebs   +5 more
semanticscholar   +1 more source

CHAPTER 2:Introduction to Structural Studies on 2-Oxoglutarate-Dependent Oxygenases and Related Enzymes

, 2015
Crystallographic studies have revealed that the Fe(ii)- and 2-oxoglutarate (2OG)-dependent oxygenases and structurally related enzymes employ a conserved double-stranded β-helix (DSBH, or jelly-roll) fold to enable oxidation of a wide range of substrates.
W. Aik, R. Chowdhury, I. Clifton, Richard J. Hopkinson, T. Leissing, M. McDonough, R. Nowak, C. Schofield, L. Walport   +8 more
semanticscholar   +1 more source

Highly selective but multifunctional oxygenases in secondary metabolism.

Accounts of Chemical Research, 2014
Biosynthesis of bioactive natural products frequently features oxidation at multiple sites. Starting from a relatively reduced chemical scaffold that is assembled by controlled polymerization of small precursors, for example, acetate or amino acids, a ...
Rachel V. K. Cochrane, J. Vederas
semanticscholar   +1 more source

Heme-Containing Oxygenases.

Chemical Reviews, 1996
M. Sono, M. Roach, E. Coulter, J. Dawson
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Rhizobacter gummiphilus NS21 has two rubber oxygenases (RoxA and RoxB) acting synergistically in rubber utilisation

Applied Microbiology and Biotechnology, 2018
Jakob Birke, Wolf Röther, D. Jendrossek
semanticscholar   +1 more source

X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis

Nature, 2015
K. Haslinger, Madeleine Peschke, Clara Brieke, E. Maximowitsch, M. Cryle   +4 more
semanticscholar   +1 more source