Results 241 to 250 of about 80,806 (371)

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

Cell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai, Jialei Hua, Donghua Meng, Yue Xu, Benfu Zhong, Miao Liu, Zhaosong Wang, Wei Zhou, Liming Liu, Hailong Wang, Yang Liu, Lifang Li, Xiuju Chen, Yueguo Li   +13 more
wiley   +1 more source

Nature of the Reactive Biferric Peroxy Intermediate P' in the Arylamine Oxygenases and Related Binuclear Fe Enzymes. [PDF]

J Am Chem Soc
Böttger LH, DeWeese DE, Iyer SR, Komor AJ, Rogers MS, Sutherlin K, Jacobs AB, Yoda Y, Kitao S, Kobayashi Y, Zhao J, Alp EE, Saito M, Seto M, Que L, Lipscomb JD, Solomon EI.   +16 more
europepmc   +1 more source

The Oxidation Reaction Catalyzed by Oxygenases and Organic Chemical Approaches to the Biological Oxidation

, 1973
Masako Nakagawa
openalex   +2 more sources

KYNA Ameliorates Hepatic Ischemia–Reperfusion Injury by Activating the Hippo Signalling Pathway via FTO‐Dependent m6A Demethylation of LATS1

Cell Proliferation, EarlyView.
Our study elucidates the cellular and molecular mechanisms underlying KYNA's protective effects against HIRI. It emphasises that KYNA modulates the methylation status of the Hippo signalling pathway through the activation of AHR, thereby mitigating damage by promoting LATS1 degradation and facilitating the nuclear translocation of YAP. ABSTRACT Hepatic
Wenjie Zheng, Xiaowen Wang, Haoqi Chen, Kaiming He, Xijing Yan, Yuan Zhang, Yang Yang, Peng Zhang, Wenfeng Zhu, Shuguang Zhu, Hua Li   +10 more
wiley   +1 more source

Reductive Cleavage of Dioxygen Mediated by a Lewis Superacidic Bis(borane). [PDF]

JACS Au
Escomel L, Vendier L, Gatineau D, Molton F, Duboc C, Gennari M, Simonneau A.   +6 more
europepmc   +1 more source

Spectroscopic analyses of 2-oxoglutarate-dependent oxygenases: TauD as a case study

JBIC Journal of Biological Inorganic Chemistry, 2017
D. Proshlyakov, J. McCracken, R. Hausinger   +2 more
semanticscholar   +1 more source

Autophagy in PE: Dispute, Role and Potential Target

Cell Proliferation, EarlyView.
Autophagy homeostasis serves as a central hub regulating vascular remodelling during pregnancy. It integrates maternal, genetic, and fetal factors; shapes the functions of immune cells (NK cells, macrophages, and T cells); restrains endothelial inflammatory responses (cytokines, endothelial cell, oxidative/ER stress, and protein aggregation); and ...
Miao Xu, Qi Wang, Fang Wang, Li Kang, Huijing Ma, Mengnan Li, Zhuanghui Hao, Zhengrui Li, Ji'an Liu, Xufeng Huang, Hengrui Liu, Shouxin Wei, Hailan Yang   +12 more
wiley   +1 more source

Biocatalytic Strategies for Nitration Reactions. [PDF]

JACS Au
Wang X, Aleotti M, Hall M, Cong Z.
europepmc   +1 more source

Utilization of Oxygenase Especially Tyrosinase in the Field of Organic Synthesis

, 1975
Toshio Ishikawa, Tsutomu Nishimura
openalex   +2 more sources

A guide to heat shock factors as multifunctional transcriptional regulators

The FEBS Journal, EarlyView.
The heat shock factors (HSFs) are evolutionarily conserved transcription factors best known as regulators of molecular chaperone genes in response to heat shock and other protein‐damaging stresses. Vertebrate HSFs, HSF1‐5, HSFX, and HSFY, are implicated in various physiological and pathological processes, including organismal development and cancer ...
Hendrik S. E. Hästbacka, Alejandro J. Da Silva, Lea Sistonen, Eva Henriksson   +3 more
wiley   +1 more source