Selective COX-2 inhibitors and risk of myocardial infarction [PDF]
, 2005 Selective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the formation of prostanoids.
Klauss, V. +3 more
core +1 more source
Effects of heme oxygenase isozymes on Leydig cells steroidogenesis [PDF]
, 2009 In the present study, we demonstrate the expression of heme oxygenase (HO) isozymes, HO-1 and HO-2 (listed as HMOX1 and HMOX2 in the MGI Database), in MA-10 Leydig tumor cells and its effect on steroidogenesis. The well-known HO inducer, hemin, increased
Besio Moreno, Marcos Alberto +6 more
core +1 more source
Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans
Scientific Reports, 2022 The JmjC family of 2-oxoglutarate dependent oxygenases catalyse a range of hydroxylation and demethylation reactions in humans and other animals. Jumonji domain-containing 7 (JMJD7) is a JmjC (3S)-lysyl-hydroxylase that catalyses the modification of ...
Rasheduzzaman Chowdhury +5 more
doaj +1 more source
Strigolactone biosynthesis is evolutionarily conserved, regulated by phosphate starvation and contributes to resistance against phytopathogenic fungi in a moss, Physcomitrella patens [PDF]
, 2017 In seed plants, strigolactones (SLs) regulate architecture and induce mycorrhizal symbiosis in response to environmental cues. SLs are formed by combined activity of the carotenoid cleavage dioxygenases (CCDs) 7 and 8 from 9-cis-β-carotene, leading to ...
Alder, Adrian +11 more
core +1 more source
ENGINEERING NON-HEME MONO- AND DIOXYGENASES FOR BIOCATALYSIS
Computational and Structural Biotechnology Journal, 2012 Oxygenases are ubiquitous enzymes that catalyze the introduction of one or two oxygen atoms to unreactive chemical compounds. They require reduction equivalents from NADH or NADPH and comprise metal ions, metal ion complexes, or coenzymes in their active
Adi Dror, Ayelet Fishman
doaj +3 more sources
Assays for the Detection of Rubber Oxygenase Activities
Bio-Protocol, 2017 Microbial biodegradation of rubber relies on extracellular rubber oxygenases that catalyze the oxidative cleavage of the double bond of the polyisoprene backbone into oligo-isoprenoids.
Wolf Röther +2 more
doaj +1 more source
Spin-orbit coupling effects in O(2) activation by cofactor-independent 2,4-dioxygenase [PDF]
The Ukrainian Biochemical Journal, 2019 The O2 (dioxygen) is paramagnetic molecule with two non-paired electron spins and triplet ground state (S = 1) while majority of organic molecules are diamagnetic species; they have all electron spins paired and the singlet ground state with the total ...
B. F. Minaev, R. R. Valiev
doaj +1 more source
(Per)chlorate-reducing bacteria can utilize aerobic and anaerobic pathways of aromatic degradation with (per)chlorate as an electron acceptor. [PDF]
, 2015 UnlabelledThe pathways involved in aromatic compound oxidation under perchlorate and chlorate [collectively known as (per)chlorate]-reducing conditions are poorly understood.
Bauer, Stefan +7 more
core +3 more sources
The specificity of cysteamine oxygenase
FEBS Letters, 1975 Oxidation of cysteamine to hypotaurine is catalyzed by cysteamine oxygenase (EC 1.13.11.19), a non-heme iron enzyme of large distribution [l-3] . A similar oxidation of cysteine to cysteine sulfinic acid has been reported to require a different oxygenase [4,.5]. Specificity of cysteamine oxygenase has been studied earlier in this laboratory by assaying
Federici G +5 more
openaire +3 more sources
Structural basis for divergent C–H hydroxylation selectivity in two Rieske oxygenases
Nature Communications, 2020 Rieske oxygenases are iron-dependent enzymes that catalyse C–H mono- and dihydroxylation reactions. Here, the authors characterise two cyanobacterial Rieske oxygenases, SxtT and GxtA that are involved in the biosynthesis of paralytic shellfish toxins and
April L. Lukowski +3 more
doaj +1 more source