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Clinical Pharmacology & Therapeutics, 2011 The treatment of gout requires a lowering of serum urate (SU) levels, and allopurinol is the drug that is most commonly used for this purpose. The objectives of this study were to define the relationships between allopurinol dose on the one hand and plasma oxypurinol, renal function, and SU levels on the other and to determine the minimum plasma ...
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Oxypurinol administration fails to prevent hypoxic–ischemic brain injury in neonatal rats
Brain Research Bulletin, 2003The purpose of the present study was to determine whether oxypurinol, a xanthine oxidase inhibitor, reduces free radicals and brain injury in the rat pup hypoxic-ischemia (HI) model. Seven-day-old rat pups had right carotid arteries ligated followed by 2.5h of hypoxia (8% oxygen). Oxypurinol or vehicle was administered by i.p.
Yangzheng, Feng +3 more
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Effect of Lactate Infusion on Renal Transport of Purine Bases and Oxypurinol
Nephron, 1993To investigate whether or not lactic acid inhibits the renal transport of oxypurines and oxypurinol, we administered physiological saline containing 0.2 mol sodium lactate to 5 normal subjects intravenously. Lactate infusion decreased the fractional clearance of uric acid, but the fractional clearances of hypoxanthine, xanthine and oxypurinol were not ...
T, Yamamoto +4 more
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Quantitative Liquid Chromatography of Allopurinol and Oxypurinol in Human Plasma and Urine
Therapeutic Drug Monitoring, 1985A high performance liquid chromatographic (HPLC) assay is described for allopurinol and oxypurinol determination in human plasma and urine, in the range expected during therapy. The procedure involves addition of trichloroacetic acid to samples, followed by centrifugation.
J M, Failler, R, Farinotti, A, Dauphin
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Effect of Glucose Infusion on the Renal Transport of Purine Bases and Oxypurinol
Nephron, 1995The effect of glucose infusion on renal handling of purine bases and oxypurinol was examined in 6 normal subjects. Five hundred milliliters of 1.1 M glucose solution were administered intravenously in 1 h. Fractional clearances of uric acid, xanthine and oxypurinol were significantly increased during glucose infusion, but that of hypoxanthine was not ...
Y, Moriwaki +4 more
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Renal clearances of oxypurinol and inulin on an isocaloric, low-protein diet
Clinical Pharmacology and Therapeutics, 1988In previous studies a low-calorie, low-protein diet caused a sustained reduction in both oxypurinol and uric acid renal clearances (CLR). With the hypothesis that the decrease in CLR was due to the low-protein and not the low-caloric content of the diet, we studied the CLR of oxypurinol, uric acid, creatinine, and inulin in normal subjects during ...
T M, Kitt +4 more
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Deoxycoformycin and oxypurinol: protection against focal ischemic brain injury in the rat
Brain Research, 1992We have previously demonstrated that oxypurinol (40 mg/kg i.p.), a xanthine oxidase inhibitor, can reduce focal ischemic brain injury in the rat when applied pre-ischemically. By using a model of occlusion of the middle cerebral artery (MCA) in tandem with occlusion of the ipsilateral carotid artery, the present study further demonstrates that delayed (
Y, Lin, J W, Phillis
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1989
In normal persons and gouty subjects, allopurinol is mainly converted to oxypurinol by xanthine oxidase and oxypurinol is then excreted unchanged by the kidney1. The concentration of serum oxypurinol is directly related to the renal clearance of oxypurinol2, which is increased or decreased under various conditions2, 3.
T, Yamamoto +4 more
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In normal persons and gouty subjects, allopurinol is mainly converted to oxypurinol by xanthine oxidase and oxypurinol is then excreted unchanged by the kidney1. The concentration of serum oxypurinol is directly related to the renal clearance of oxypurinol2, which is increased or decreased under various conditions2, 3.
T, Yamamoto +4 more
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Plasma oxypurinol concentration in a patient with allopurinol hypersensitivity.
The Journal of rheumatology, 1989Monitoring of plasma oxypurinol has been proposed to prevent allopurinol side effects. An 89-year-old man developed a severe desquamative rash, fever, eosinophilia, hepatocellular injury and renal failure after allopurinol administration. Eight hours after the last dose, plasma allopurinol was undetectable and plasma oxypurinol was 50 mumol/l.
J G, Puig +4 more
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