Results 151 to 160 of about 1,837 (187)
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Oxypurinol Protects Normothermic Ischemic Hearts
Journal of Cardiac Surgery, 1990Rabbit hearts were mounted on a Langendorff apparatus and after measurement of baseline hemodynamic function exposed to 30 minutes normothermic arrest. Hearts were reperfused at 37 degrees C with buffer solution containing oxypurinol in different concentration: group II (0.01 mM), group III (0.1 mM), group IV (1 mM). Group I did not receive active drug
J, Bergsland +4 more
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Allopurinol and oxypurinol in human breast milk
The Clinical Investigator, 1993To pregnant or breast feeding women drugs should be given with caution. We report the case of a 5-week-old breast-fed infant whose mother was taking 300mg allopurinol/day for 4 weeks. Allopurinol and oxypurinol were detected by HPLC in maternal plasma and breast milk with a method first described here.
I, Kamilli, U, Gresser
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Plasma oxypurinol as a measure of adherence in clinical trials
Annals of the Rheumatic Diseases, 2018Adherence to urate-lowering therapy (ULT) in people with gout is often poor. A recent systematic review revealed 10%–46% of people with gout adhere to treatment.1 Among chronic diseases, gout has particularly low adherence rates.2 Adherence in clinical trials of ULT is a particularly important issue, as the primary efficacy endpoint for most studies ...
Lisa K, Stamp +6 more
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Allergic Reaction to Allopurinol with Cross-Reactivity to Oxypurinol
Annals of Internal Medicine, 1976A 25-year-old white man with gout and nephropathy and with a previous reaction to allopurinol was given a trial dose of oxypurinol. He developed malaise, a generalized erythematous reaction with edema, pruritus, and emesis; this was clinically identical to the reaction he experienced with allopurinol.
O, Lockard +3 more
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The Effect of Dietary Protein on the Clearance of Allopurinol and Oxypurinol
New England Journal of Medicine, 1985A decrease in dietary protein is known to depress renal plasma flow and creatinine clearance. Using a randomized crossover design, we investigated the pharmacokinetics of allopurinol and its principal metabolite, oxypurinol, after oral administration of 600 mg of allopurinol in six normal subjects receiving a high-protein (268 g per day) or low-protein
W G, Berlinger, G D, Park, R, Spector
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Free Radical Research Communications, 1988
Allopurinol has been employed as a "specific" inhibitor of xanthine oxidase in studies of hypoxic/reoxygenation injury. Pulse radiolysis was used to establish rate constants for the reactions of allopurinol and its major metabolite oxypurinol with hydroxyl radicals: values were (1.45 +/- 0.24) x 10(9) M-1 s-1 for allopurinol and (4.95 +/- 0.84) x 10(9)
B M Hoey, Barry Halliwell
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Allopurinol has been employed as a "specific" inhibitor of xanthine oxidase in studies of hypoxic/reoxygenation injury. Pulse radiolysis was used to establish rate constants for the reactions of allopurinol and its major metabolite oxypurinol with hydroxyl radicals: values were (1.45 +/- 0.24) x 10(9) M-1 s-1 for allopurinol and (4.95 +/- 0.84) x 10(9)
B M Hoey, Barry Halliwell
exaly +3 more sources
Oxypurinol reduces focal ischemic brain injury in the rat
Neuroscience Letters, 1991When measured within 2 days of a unilateral occlusion of the middle cerebral artery (MCA) combined with tandem occlusion of the ipsilateral common carotid artery in rats, contralateral neurological deficits were detectable, with brain swelling and a consistent degree of neocortical infarction in the ipsilateral hemisphere.
Y, Lin, J W, Phillis
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Effect of furosemide on renal excretion of oxypurinol and purine bases
Metabolism, 2001To examine whether furosemide affects the plasma concentration and urinary excretion of purine bases and oxypurinol, we administered allopurinol (300 mg) orally to 6 healthy subjects and then administered furosemide (20 mg) intravenously 10 hours later. Furosemide (20 mg) decreased the urinary excretion of uric acid by 40% (P < .01), oxypurinol by 39% (
T, Yamamoto +4 more
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Urinary-Tract Stones Resulting from the Excretion of Oxypurinol
New England Journal of Medicine, 1975COMPOUNDS that inhibit the enzyme, xanthine oxidase, are useful in the treatment of disorders of purine metabolism.
A R, Landgrebe, W L, Nyhan, M, Coleman
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The pharmacokinetics of oral and intravenous allopurinol and intravenous oxypurinol in the horse
Journal of Veterinary Pharmacology and Therapeutics, 1995The pharmacokinetics of oral and intravenous allopurinol was studied in five horses and compared with intravenous oxypurinol. The plasma concentration vs. time curves, following intravenous administration of 5 mg/kg, were best described by the biexponential equations Cp = 106.58e‐25.141+ 159.93e‐10.96tfor allopurinol and Cp = 321.09e‐972t+ 82.39e‐0 ...
P C, Mills, M, Dunnett, N C, Smith
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