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Effect of Amino Acids on the Excretions of Purine Bases and Oxypurinol
Nephron, 2008To investigate whether or not amino acids affect the urinary excretion of purine bases and oxypurinol, a 12% amino acid solution was infused to 6 subjects who took allopurinol (300 mg) 6 h before the study. Amino acid infusion increased the urinary excretion and the fractional clearance of uric acid and oxypurinol and decreased the plasma concentration
T, Yamamoto +4 more
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The effect of benzbromarone on allopurinol/oxypurinol kinetics in patients with gout
European Journal of Clinical Pharmacology, 1993The objectives of this study were to establish if, and to what extent, benzbromarone affects allopurinol/oxypurinol kinetics, and to compare the uric acid lowering capabilities of Allomaron (allopurinol 100 mg plus benzbromarone 20 mg) with the effects of allopurinol alone in patients with confirmed gout.
F O, Müller +5 more
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Oxypurinol – A novel marker for wastewater contamination of the aquatic environment
Water Research, 2015The anti-gout agent allopurinol is one of the most prescribed pharmaceuticals in Germany and is widely metabolized into oxypurinol (80%) as well as the corresponding riboside conjugates (10%) within the human body. To investigate the occurrence of allopurinol and oxypurinol in the urban water cycle an analytical method was developed based on solid ...
Jan Funke +3 more
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Effect of norepinephrine on the urinary excretion of purine bases and oxypurinol
Metabolism, 2001To examine whether norepinephrine affects the plasma concentrations and urinary excretion of purine bases and oxypurinol, we orally administered allopurinol (300 mg) to 5 healthy subjects and 9 hours later intravenously administered norepinephrine (12 to 20 microg/kg body weight), which causes a more than 10 mm Hg increase in diastolic pressure for 2 ...
T, Yamamoto +4 more
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Oxypurinol Nephrolithiasis in Regional Enteritis Secondary to Allopurinol Therapy
Annals of Internal Medicine, 1980A patient with regional enteritis and recurrent uric acid nephrolithiasis was treated with allopurinol. While on 600 mg of allopurinol daily, she began to pass many small, soft, yellow stones. Analysis of the stones by liquid chromatographic and gas chromatograph/mass spectrometric techniques revealed that their major constituent was oxypurinol, a ...
R M, Stote +5 more
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Allopurinol hypersensitivity syndrome: hypersensitivity to oxypurinol but not allopurinol
Clinical and Experimental Dermatology, 1998Allopurinol is a xanthine oxidase inhibitor widely used to control plasma uric acid levels. Episodes of hypersensitivity to the drug are not rare. A severe form of this with a generalized exanthem, fever and liver involvement has been termed the allopurinol hypersensitivity syndrome (AHS).
null HAMANAKA +4 more
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A population pharmacokinetic model to predict oxypurinol exposure in patients on haemodialysis
European Journal of Clinical Pharmacology, 2016The aims of this study were to characterise the population pharmacokinetics of oxypurinol in patients receiving haemodialysis and to compare oxypurinol exposure in dialysis and non-dialysis patients.Oxypurinol plasma concentrations from 6 gout people receiving haemodialysis and 19 people with gout not receiving dialysis were used to develop a ...
Daniel F B Wright +2 more
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Renal clearances of oxypurinol and inulin on an isocaloric, low-protein diet
Clinical Pharmacology and Therapeutics, 1988In previous studies a low-calorie, low-protein diet caused a sustained reduction in both oxypurinol and uric acid renal clearances (CLR). With the hypothesis that the decrease in CLR was due to the low-protein and not the low-caloric content of the diet, we studied the CLR of oxypurinol, uric acid, creatinine, and inulin in normal subjects during ...
T M, Kitt +4 more
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Effect of Glucose Infusion on the Renal Transport of Purine Bases and Oxypurinol
Nephron, 2008The effect of glucose infusion on renal handling of purine bases and oxypurinol was examined in 6 normal subjects. Five hundred milliliters of 1.1 M glucose solution were administered intravenously in 1 h. Fractional clearances of uric acid, xanthine and oxypurinol were significantly increased during glucose infusion, but that of hypoxanthine was not ...
Y, Moriwaki +4 more
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Beneficial effects of oxypurinol pretreatment in stunned, reperfused canine myocardium
Cardiovascular Research, 1989The mechanism of reperfusion induced injury in acutely ischaemic myocardium is controversial but may be connected with oxygen free radical generation. However, chronic allopurinol treatment has beneficial effects in ischaemic myocardium which are not due to its inhibition of xanthine oxidase induced oxygen free radical production.
H H, Holzgrefe, J K, Gibson
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