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Oxypurinol Reduces Ischemic Brain Injury in the Gerbil and Rat
1991The pathophysiology of brain ischemia is characterized by a complex sequence of events, which include biochemical, hemodynamic and electrophysiological processes. Decreases in cerebral blood flow (CBF) below a critical threshold result in energy failure, tissue acidosis, disturbed ion homeostasis, with cellular Na+ and Ca++ influx and K+ efflux ...
J W, Phillis, Y, Lin
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The Allopurinol Hypersensitivity Syndrome: Its Relation to Plasma Oxypurinol Levels
1989Allopurinol (4-hydroxypyrazolo (3, 4-d)pyrimidine) is a potent inhibitor of uric acid synthesis commonly prescribed for the treatment of gout and other hyperuricemic states (1, 2). Most of the allopurinol is rapidly oxidized to oxypurinol, its major metabolic product (3), which in turn is a potent inhibitor of the enzyme xanthine oxydase.
E, Casas +5 more
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Effect of Lactate Infusion on Renal Transport of Purine Bases and Oxypurinol
Nephron, 2008To investigate whether or not lactic acid inhibits the renal transport of oxypurines and oxypurinol, we administered physiological saline containing 0.2 mol sodium lactate to 5 normal subjects intravenously. Lactate infusion decreased the fractional clearance of uric acid, but the fractional clearances of hypoxanthine, xanthine and oxypurinol were not ...
T, Yamamoto +4 more
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Effect of Losartan and Furosemide on the Urinary Excretion of Oxypurinol and Uric Acid
2006Losartan potassium (losartan) is an angiotensin II receptor antagonist used for the treatment of hypertension1, which opposes the action of angiotensin II at the AT1 receptor. Losartan has a uricosuric action, which depends on the inhibition of uric acid reabsorption in the proximal tubules2.
T, Yamamoto +4 more
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1989
In normal persons and gouty subjects, allopurinol is mainly converted to oxypurinol by xanthine oxidase and oxypurinol is then excreted unchanged by the kidney1. The concentration of serum oxypurinol is directly related to the renal clearance of oxypurinol2, which is increased or decreased under various conditions2, 3.
T, Yamamoto +4 more
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In normal persons and gouty subjects, allopurinol is mainly converted to oxypurinol by xanthine oxidase and oxypurinol is then excreted unchanged by the kidney1. The concentration of serum oxypurinol is directly related to the renal clearance of oxypurinol2, which is increased or decreased under various conditions2, 3.
T, Yamamoto +4 more
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Plasma oxypurinol concentration in a patient with allopurinol hypersensitivity.
The Journal of rheumatology, 1989Monitoring of plasma oxypurinol has been proposed to prevent allopurinol side effects. An 89-year-old man developed a severe desquamative rash, fever, eosinophilia, hepatocellular injury and renal failure after allopurinol administration. Eight hours after the last dose, plasma allopurinol was undetectable and plasma oxypurinol was 50 mumol/l.
J G, Puig +4 more
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Oxypurinol as an inhibitor of xanthine oxidase-catalyzed production of superoxide radical
Biochemical Pharmacology, 1988A recent study of the mechanism by which oxypurinol inhibits uric acid generation [T. Spector, W. W. Hall and T. A. Krenitsky, Biochem. Pharmac. 35, 3109(1986)] showed that xanthine is ineffective in impeding the binding of oxypurinol to reduced xanthine oxidase. This study prompted the present hypothesis that, at elevated concentrations of substrates,
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An allopurinol adherence tool using plasma oxypurinol concentrations
British Journal of Clinical Pharmacology, 2023Sophie L Stocker +2 more
exaly
Analysis of allopurinol and oxypurinol in plasma and its application to metabolic studies
Biopharmaceutics & Drug Disposition, 1980S, Sved, D L, Wilson
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