Results 21 to 30 of about 959 (115)

Design, Synthesis and Structure-Activity Relationship Studies of Novel Survivin Inhibitors with Potent Anti-Proliferative Properties. [PDF]

PLoS ONE, 2015
The anti-apoptotic protein survivin is highly expressed in most human cancer cells, but has very low expression in normal differentiated cells. Thus survivin is considered as an attractive cancer drug target.
Min Xiao, Jin Wang, Zongtao Lin, Yan Lu, Zhenmei Li, Stephen W White, Duane D Miller, Wei Li   +7 more
doaj   +1 more source

Design, synthesis and pharmacological evaluation of 4-(3-chloro-4-(3-cyclopropylthioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxamide (WXFL-152): a novel triple angiokinase inhibitor for cancer therapy

Acta Pharmaceutica Sinica B, 2020
Angiokinases, such as vascular endothelial-, fibroblast- and platelet-derived growth factor receptors (VEGFRs, FGFRs and PDGFRs) play crucial roles in tumor angiogenesis.
Yuqin Yao, Zhuowei Liu, Manyu Zhao, Zhengxia Chen, Peng Li, Yang Zhang, Yuxi Wang, Chengjian Zhao, Chaofeng Long, Xiaoxin Chen, Jinliang Yang   +10 more
doaj   +1 more source

Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model

Antioxidants, 2020
A novel potent analog of the branched tail oxyquinoline group of hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors, neuradapt, has been studied in two treatment regimes in an in vitro hypoxia model on murine primary hippocampal cultures ...
Maria Savyuk, Mikhail Krivonosov, Tatiana Mishchenko, Irina Gazaryan, Mikhail Ivanchenko, Anna Khristichenko, Andrey Poloznikov, Dmitry Hushpulian, Sergey Nikulin, Evgeny Tonevitsky, Guzal Abuzarova, Elena Mitroshina, Maria Vedunova   +12 more
doaj   +1 more source

The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease

Neurobiology of Disease, 2020
Identifying disease-causing pathways and drugs that target them in Parkinson's disease (PD) has remained challenging. We uncovered a PD-relevant pathway in which the stress-regulated heterodimeric transcription complex CHOP/ATF4 induces the neuron ...
Pascaline Aimé, Saravanan S. Karuppagounder, Apeksha Rao, Yingxin Chen, Robert E. Burke, Rajiv R. Ratan, Lloyd A. Greene   +6 more
doaj   +1 more source

Inhibitor of Differentiation‐3 and Estrogenic Endocrine Disruptors: Implications for Susceptibility to Obesity and Metabolic Disorders

BioMed Research International, Volume 2018, Issue 1, 2018., 2018
The rising global incidence of obesity cannot be fully explained within the context of traditional risk factors such as an unhealthy diet, physical inactivity, aging, or genetics. Adipose tissue is an endocrine as well as a metabolic organ that may be susceptible to disruption by environmental estrogenic chemicals.
Mayur Doke, Vincent Avecilla, Quentin Felty, Stephen H. Safe   +3 more
wiley   +1 more source

Stem Cell Tracking Technologies for Neurological Regenerative Medicine Purposes

Stem Cells International, Volume 2017, Issue 1, 2017., 2017
The growing field of stem cell therapy is moving toward clinical trials in a variety of applications, particularly for neurological diseases. However, this translation of cell therapies into humans has prompted a need to create innovative and breakthrough methods for stem cell tracing, to explore the migration routes and its reciprocity with ...
Yongtao Zheng, Jiongwei Huang, Tongming Zhu, Ronggang Li, Zhifu Wang, Fukai Ma, Jianhong Zhu, Yao Li   +7 more
wiley   +1 more source

Sildenafil in the treatment of pressure ulcer: a randomised clinical trial

International Wound Journal, Volume 12, Issue 1, Page 111-117, February 2015., 2015
Abstract Pressure ulcer (PrU)‐related hospitalisation and mortality are critical issues in medical and surgical patients. Although animal studies have suggested the beneficial effects of sildenafil on wound healing, related clinical data are lacking. This is the first clinical study that has evaluated the effects of topical sildenafil on PrU healing in
Shadi Farsaei, Hossein Khalili, Effat S Farboud, Zahra Khazaeipour   +3 more
wiley   +1 more source

Synthesis of 5-oxyquinoline derivatives for reversal of multidrug resistance

Beilstein Journal of Organic Chemistry, 2012
The inhibition of ABC (ATP binding cassette) transporters is considered a powerful tool to reverse multidrug resistance. Zosuquidar featuring a difluorocyclopropyl-annulated dibenzosuberyl moiety has been found to be an inhibitor of the P-glycoprotein ...
Torsten Dittrich, Nils Hanekop, Nacera Infed, Lutz Schmitt, Manfred Braun   +4 more
doaj   +1 more source

Noneczematous Contact Dermatitis

International Scholarly Research Notices, Volume 2013, Issue 1, 2013., 2013
Irritant or allergic contact dermatitis usually presents as an eczematous process, clinically characterized by erythematoedematovesicous lesions with intense itching in the acute phase. Such manifestations become erythematous‐scaly as the condition progresses to the subacute phase and papular‐hyperkeratotic in the chronic phase.
Domenico Bonamonte, Caterina Foti, Michelangelo Vestita, Gianni Angelini, D. C. Cara, B. F. Gibbs, Y. L. Ye, Z. Zhu   +7 more
wiley   +1 more source

Leukocytosis of Unknown Origin: Gangrenous Cholecystitis

Case Reports in Medicine, Volume 2013, Issue 1, 2013., 2013
There have been case reports where patients admitted with acute cholecystitis, who were managed conservatively, had subsequently developed GC (gangrenous cholecystitis). The current case is unique, since our patient denied any prior episodes of abdominal pain and the only tip off was leukocytosis.
Amara Jyothi Nidimusili, M. Chadi Alraies, Naseem Eisa, Abdul Hamid Alraiyes, Khaldoon Shaheen, Gianfranco D. Alpini   +5 more
wiley   +1 more source