Results 151 to 160 of about 7,074 (183)
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Oxysterols increase in diabetic rats
Free Radical Research, 2005To address whether diabetes enhances lipid peroxidation and attenuates nitric oxide (NO) generation resulting in tissue complications, we measured oxysterols and NO metabolites (NOx) in the tissues of diabetic Wistar rats. After 4 weeks of streptozotocin injection (STZ, 80 mg/kg, i.p.), we measured 7 alpha- and 7 beta-hydroperoxycholest-5-en-3 beta-ol (
Naoki, Yoshioka +3 more
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Oxysterols and Alcoholic Liver Disease
Alcoholism: Clinical and Experimental Research, 1990A new theory is presented implicating oxidative cholesterol metabolism and oxysterols as possible factors in the development of alcoholic liver disease. Our present studies have revealed the accumulation of cholesta‐3,5‐dien‐7‐one, 13.05 ± 2.75 μg/g (n = 8), and cholesta‐4,6‐dien‐3‐one, 2.26 ± 0.88 μg/g (n = 8) in fatty alcoholic liver, as compared ...
M T, Ryzlak +3 more
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Oxysterols in bile acid metabolism
Clinica Chimica Acta, 2011Increasing body of evidence is available indicating that oxysterols are more much than intermediates of metabolic pathways. Oxysterols play a role in the regulation of cholesterol synthesis, transport and efflux. A scavenger effect of cholesterol 27-hydroxylase on elevated serum cholesterol levels is well demonstrated.
Crosignani, A +3 more
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Oxysterols: Old Tale, New Twists
Annual Review of Pharmacology and Toxicology, 2016Oxysterols have long been known for their important role in cholesterol homeostasis, where they are involved in both transcriptional and posttranscriptional mechanisms for controlling cholesterol levels. However, they are increasingly associated with a wide variety of other, sometimes surprising cell functions.
Winnie, Luu +4 more
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Oxysterols suppress constitutive fibrinogen expression
Thrombosis and Haemostasis, 2003SummaryElevated levels of both fibrinogen and cholesterol are risk factors in coronary artery disease. Previously we reported a metabolic link between fibrinogen and lipid metabolism in that HepG2 cells that were programmed by transfection of Bβ-fibrinogen cDNA to overexpress fibrinogen exhibited increased synthesis of cholesterol and increased ...
Hui, Xia, Colvin M, Redman
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1987
Studies of the regulation of cholesterol biosynthesis in mammalian cells have led to a model in which transcription of the mRNA for the regulatory enzyme, 3-hydroxy-3-methylglutaryl coenzyme A ((HMG-CoA) reductase, is controlled by an endogenous oxysterol metabolite(s) bound to a specific oxysterol receptor (1,2, Fig 1). Since this regulatory mechanism
Taylor, F R, Kandutsch, A A
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Studies of the regulation of cholesterol biosynthesis in mammalian cells have led to a model in which transcription of the mRNA for the regulatory enzyme, 3-hydroxy-3-methylglutaryl coenzyme A ((HMG-CoA) reductase, is controlled by an endogenous oxysterol metabolite(s) bound to a specific oxysterol receptor (1,2, Fig 1). Since this regulatory mechanism
Taylor, F R, Kandutsch, A A
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Mechanisms of oxysterol-induced apoptosis
Current Opinion in Lipidology, 2001The rationale for the present review is that oxysterols found in oxidized LDL (oxLDL) play a role in atherogenesis. This perspective is based on studies that show that induction of apoptosis in vascular cells is an important process in atherogenesis, that apoptosis can be induced by oxLDL, and that the oxysterol component of oxLDL is responsible for ...
Panini, S. R., Sinensky, M. S.
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A proteolytic fragment of the oxysterol receptor which retains oxysterol binding activity
Archives of Biochemistry and Biophysics, 1991The structural organization of the oxysterol receptor, postulated to be involved in the regulation of 3-hydroxy-3-methylglutaryl CoA reductase and cholesterol biosynthesis in mammalian cells, has been explored by limited proteolysis with trypsin, alpha-chymotrypsin, and endoproteinase GluC.
Taylor, F R, Shown, E P, Kandutsch, A A
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Oxysterols: Genesis and basic functions
Russian Journal of Bioorganic Chemistry, 2007The structural peculiarities of the most widespread oxysterols, the products of oxidative transformations of cholesterol are discussed. The transformations proceed with the participation of enzymatic systems of the body or as a result of various nonenzymatic reactions. The pathways of their formation from cholesterol are also considered.
A V, Antonchik +2 more
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Connective tissue responses to oxysterols
Atherosclerosis, 1982We studied the effect of sterols and oxidized sterols on promoting tissue inflammation and necrosis, and on causing cell death in tissue culture. The cells studied were mouse fibroblasts and macrophages, and pig vascular smooth muscle. The lipid preparations were dibromide-purified cholesterol, air-oxidized cholesterol, 25-hydroxycholesterol ...
A, Baranowski +3 more
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