Results 11 to 20 of about 7,074 (183)
Mechanisms of oxysterol-induced carcinogenesis [PDF]
Lipids in Health and Disease, 2011 Oxysterols are oxidation products of cholesterol that are generated by enzymatic reactions mediated by cytochrome P450 family enzymes or by non-enzymatic reactions involving reactive oxygen and nitrogen species.
Loilome Watcharin +4 more
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Resilient Calvarial Bone Marrow Supports Retinal Repair in Type 2 Diabetes. [PDF]
Adv Sci (Weinh)Skull bone (calvarium) marrow in diabetic mice stay structurally intact and keeps making blood cells, unlike the bone marrow of the leg bones. The skull marrow is exposed to cerebrospinal fluid (CSF), which contains protective molecules called oxysterols.
Asare-Bediako B +16 more
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Oxysterols and retinal degeneration [PDF]
British Journal of Pharmacology, 2021 Retinal degeneration, characterised by the progressive death of retinal neurons, is the most common cause of visual impairment. Oxysterols are the cholesterol derivatives produced via enzymatic and/or free radical oxidation that regulate cholesterol homeostasis in the retina.
Zhang, Xun +6 more
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Oxysterols and Oxysterol Sulfates in Alzheimer’s Disease Brain and Cerebrospinal Fluid [PDF]
Journal of Alzheimer's Disease, 2022 Background: Brain cholesterol levels are tightly regulated but increasing evidence indicates that cholesterol metabolism may drive Alzheimer’s disease (AD)-associated pathological changes. Recent advances in understanding of mitochondrial dysfunction in AD brain have presented a vital role played by mitochondria in oxysterol biosynthesis and their ...
Dias, Irundika HK +3 more
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Chromatography of oxysterols [PDF]
Biochimie, 2018 Oxysterols play important roles in development and diseases, but can be highly challenging to analyze. To ensure satisfactory measurements, oxysterols must typically be separated with chromatography prior to detection. Here, we will devote attention to the chromatography of oxysterols, focusing on gas chromatography and liquid chromatography.
Irundika H.K. Dias +2 more
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Sulphatation does not appear to be a protective mechanism to prevent oxysterol accumulation in humans and mice. [PDF]
PLoS ONE, 2013 24S- and 27-hydroxycholesterol (24OHC and 27OHC) are potent regulators of different biochemical systems in vitro and are the major circulating oxysterols.
Jure Acimovic +11 more
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Frontiers in Nutrition, 2022 Cholesterol is a lipid of high nutritional value that easily undergoes oxidation through enzymatic and non-enzymatic pathways, leading to a wide variety of cholesterol oxidation products (COPs), more commonly named oxysterols.
Federico Canzoneri +5 more
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Multiple Targets for Oxysterols in Their Regulation of the Immune System
Cells, 2021 Oxysterols, or cholesterol oxidation products, are naturally occurring lipids which regulate the physiology of cells, including those of the immune system.
Lisa Reinmuth +4 more
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Arteriosclerosis, Thrombosis, and Vascular Biology, 2002 Oxysterols are oxygenated derivatives of cholesterol that are intermediates or even end products in cholesterol excretion pathways. Because of their ability to pass cell membranes and the blood-brain barrier at a faster rate than cholesterol itself, they are also important as transport forms of cholesterol.
Ingemar, Björkhem, Ulf, Diczfalusy
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Cholesterol metabolism: from lipidomics to immunology
Journal of Lipid Research, 2022 Oxysterols, the oxidized forms of cholesterol or of its precursors, are formed in the first steps of cholesterol metabolism. Oxysterols have interested chemists, biologists, and physicians for many decades, but their exact biological relevance in vivo ...
William J. Griffiths, Yuqin Wang
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