Results 21 to 30 of about 7,074 (183)

Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells[S]

Journal of Lipid Research, 2013
Recent studies suggest that 7-dehydrocholesterol (7-DHC)-derived oxysterols play important roles in the pathophysiology of Smith-Lemli-Opitz syndrome (SLOS), a metabolic disorder that is caused by defective 3β-hydroxysterol-Δ7-reductase (DHCR7). Although
Libin Xu, Zeljka Korade, Dale A. Rosado, Jr., Karoly Mirnics, Ned A. Porter   +4 more
doaj   +1 more source

The role of oxysterols in control of endothelial stiffness

Journal of Lipid Research, 2012
Endothelial dysfunction is a key step in atherosclerosis development. Our recent studies suggested that oxLDL-induced increase in endothelial stiffness plays a major role in dyslipidemia-induced endothelial dysfunction.
Tzu Pin Shentu, Dev K. Singh, Myung-Jin Oh, Shan Sun, Laleh Sadaat, Ayako Makino, Theodore Mazzone, Papasani V. Subbaiah, Michael Cho, Irena Levitan   +9 more
doaj   +1 more source

Evaluating the oxysterol combination of 22(S)-hydroxycholesterol and 20(S)-hydroxycholesterol in periodontal regeneration using periodontal ligament stem cells and alveolar bone healing models

Stem Cell Research & Therapy, 2017
Background Oxysterols, oxygenated by-products of cholesterol biosynthesis, play roles in various physiological and pathological systems. However, the effects of oxysterols on periodontal regeneration are unknown.
Jin-Sun Lee, EunJi Kim, Seonggu Han, Kyung Lhi Kang, Jung Sun Heo   +4 more
doaj   +1 more source

Oxysterols Protect Epithelial Cells Against Pore-Forming Toxins

Frontiers in Immunology, 2022
Many species of bacteria produce toxins such as cholesterol-dependent cytolysins that form pores in cell membranes. Membrane pores facilitate infection by releasing nutrients, delivering virulence factors, and causing lytic cell damage - cytolysis ...
Thomas J. R. Ormsby, Sian E. Owens, Liam Clement, Tom J. Mills, James G. Cronin, John J. Bromfield, Iain Martin Sheldon   +6 more
doaj   +1 more source

Cilia-Associated Oxysterols Activate Smoothened [PDF]

Molecular Cell, 2018
Primary cilia are required for Smoothened to transduce vertebrate Hedgehog signals, but how Smoothened accumulates in cilia and is activated is incompletely understood. Here, we identify cilia-associated oxysterols that promote Smoothened accumulation in cilia and activate the Hedgehog pathway.
Raleigh, DR, Sever, N, Choksi, PK, Sigg, MA, Hines, KM, Thompson, BM, Elnatan, D, Jaishankar, P, Bisignano, P, Garcia-Gonzalo, FR, Krup, AL, Eberl, M, Byrne, EFX, Siebold, C, Wong, SY, Renslo, AR, Grabe, M, McDonald, JG, Xu, L, Beachy, PA, Reiter, JF   +20 more
openaire   +7 more sources

Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol

Redox Biology, 2017
Oxysterols are known pleiotropic molecules whose antiviral action has been recently discovered. Here reported is the activity of a panel of oxysterols against HSV-1 with the identification of a new mechanism of action.
Valeria Cagno, Andrea Civra, Daniela Rossin, Simone Calfapietra, Claudio Caccia, Valerio Leoni, Nicholas Dorma, Fiorella Biasi, Giuseppe Poli, David Lembo   +9 more
doaj   +1 more source

Simvastatin reduces circulating oxysterol levels in men with hypercholesterolaemia

Redox Biology, 2018
Oxysterols (OHC) are biologically active cholesterol metabolites circulating in plasma that may be formed enzymatically (e.g. 24S-OHC, 25-OHC and 27-OHC) or by autoxidative mechanisms (e.g. 7-ketocholesterol, 7β-OHC and 25-OHC).
Irundika H.K. Dias, Ivana Milic, Gregory Y.H. Lip, Andrew Devitt, M. Cristina Polidori, Helen R. Griffiths   +5 more
doaj   +1 more source

Macrophages, Oxysterols and Atherosclerosis

Circulation Journal, 2010
Macrophages play central roles in immunity and homeostasis, and contribute to the pathogenesis of atherosclerosis through their accumulation of cholesterol and the production of inflammatory mediators and cytokines. Recent studies indicate that oxysterols influence diverse aspects of macrophage biology.
Norihito, Shibata, Christopher K, Glass
openaire   +3 more sources

Dietary oxysterols are incorporated in plasma triglyceriderich lipoproteins, increase their susceptibility to oxidation and increase aortic cholesterol concentration of rabbits

Journal of Lipid Research, 1998
Early fatty streaks and advanced lesions are characterized by the deposition of cholesterol and cholesterol oxidation products (oxysterols). Oxysterols have been shown to be cytotoxic and pro-atherogenic compared to cholesterol and are found in ...
D.F. Vine, J.C.L. Mamo, L.J. Beilin, T.A. Mori, K.D. Croft   +4 more
doaj   +1 more source

Accumulation of oxysterols in the erythrocytes of COVID-19 patients as a biomarker for case severity

Respiratory Research, 2023
Background Due to the high risk of COVID-19 patients developing thrombosis in the circulating blood, atherosclerosis, and myocardial infarction, it is necessary to study the lipidome of erythrocytes.
Alaa Khedr, Maan T. Khayat, Ahdab N. Khayyat, Hany Z. Asfour, Rahmah A. Alsilmi, Ahmed K. Kammoun   +5 more
doaj   +1 more source