Results 61 to 70 of about 7,074 (183)
A quantitative LC-MS/MS method for analysis of mitochondrial -specific oxysterol metabolism
Redox Biology, 2020 Oxysterols are critical regulators of inflammation and cholesterol metabolism in cells. They are oxidation products of cholesterol and may be differentially metabolised in subcellular compartments and in biological fluids.
Khushboo Borah +8 more
doaj +1 more source
An Australian standard of care for Niemann–Pick disease type C
Internal Medicine Journal, EarlyView.Abstract Background Niemann–Pick disease type C (NP‐C) is the fifth most prevalent lysosomal disorder in Australia. Diagnostic delay is common, impacted by disease heterogeneity, limited awareness within clinical gateway services and exclusion from state‐based newborn screening programmes.
Michel Tchan +23 more
wiley +1 more source
Medical and Veterinary Entomology, EarlyView.Leishmania infantum propagated in IDE8 tick cell line in vitro. L. infantum reduces tick cell viability and induces reactive oxygen species production. Lipidic profile of IDE8 tick cell line is altered during Leishmania infection. Abstract Leishmaniasis comprises a group of vector‐borne neglected tropical diseases caused by species of the obligatory ...
Beatriz Filgueiras Silvestre +7 more
wiley +1 more source
Comprehensive Physiology, Volume 16, Issue 2, April 2026.Pancreatic exocrine microcirculation exhibits sexual dimorphism arising from steroid–genetic interactions. Laser Doppler flowmetry combined with wavelet analysis identifies a male passive coupling phenotype aligned with systemic pressure and a female active vasomotion phenotype driven by ERβ‐mediated, NO‐dependent oscillations.
Yuan Li +8 more
wiley +1 more source
Involvement of 27-Hydroxycholesterol in Mitotane Action on Adrenocortical Carcinoma
Cells, 2020 Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis. Mitotane, the standard treatment for ACC, impairs adrenocortical steroid biosynthesis and cholesterol metabolism.
Antonina Germano +10 more
doaj +1 more source
Steroid Recognition in Adhesion GPCRs: A Structural and Pharmacological Perspective
Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.ABSTRACT Emerging evidence suggests steroids may act as generalizable ligands for adhesion GPCRs, a receptor class with considerable pharmacological potential. While most studies have focused on the ADGR‘G' subfamily, recent cryo‐EM structures of the androgens 5α‐dihydrotestosterone (5α‐DHT) and methenolone bound to ADGRD1 revealed a putative steroid ...
Bethany Fleming +4 more
wiley +1 more source
Are side-chain oxidized oxysterols regulators also in vivo?
Journal of Lipid Research, 2009 Oxsterols are oxygenated metabolites of cholesterol that are short-lived intermediates or end products in cholesterol excretion pathways. They are present in very low concentrations in mammalian systems, always accompanied by a high excess of cholesterol.
Ingemar Bjo¨rkhem
doaj +1 more source
Oxysterols as therapeutic targets [PDF]
British Journal of Pharmacology, 2021 Mark, Nixon, Ruth, Andrew
openaire +2 more sources
Pest Management Science, Volume 82, Issue 4, Page 2838-2843, April 2026.Opinion on pesticide resistance and management in the European Union (EU) and United Kingdom (UK) is presented cognisant of changes in regulation that impact on mode of action availability and cropping system choice. Abstract In recent times, pesticide resistance has been managed reasonably effectively, either proactively or reactively, by monitoring ...
Julian Smith +10 more
wiley +1 more source
Cholesterol oxidation: Health hazard and the role of antioxidants in prevention
Biological Research, 2003 Cholesterol is a molecule with a double bond in its structure and is therefore susceptible to oxidation leading to the formation of oxysterols. These oxidation products are found in many commonly-consumed foods and are formed during their manufacture and/
ALFONSO VALENZUELA +2 more
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