Results 71 to 80 of about 9,669 (153)
FEBS Letters, Volume 600, Issue 17, Page 2564-2578, September 2026.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Oxysterols. Players in different metabolic leagues
, 2017 In animals, cholesterol (C27H46O; 3b-Hydroxy-5-cholestene/5- Cholesten-3b-ol) is a widely present molecule. Iitially named cholesterine, cholesterol was discovered in 1815 by Eugène Chevreul.
Lizard, Gérard +5 more
core +1 more source
Cholesterol oxidation: Health hazard and the role of antioxidants in prevention
Biological Research, 2003 Cholesterol is a molecule with a double bond in its structure and is therefore susceptible to oxidation leading to the formation of oxysterols. These oxidation products are found in many commonly-consumed foods and are formed during their manufacture and/
ALFONSO VALENZUELA +2 more
doaj
Are side-chain oxidized oxysterols regulators also in vivo?
Journal of Lipid Research, 2009 Oxsterols are oxygenated metabolites of cholesterol that are short-lived intermediates or end products in cholesterol excretion pathways. They are present in very low concentrations in mammalian systems, always accompanied by a high excess of cholesterol.
Ingemar Bjo¨rkhem
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, Volume 600, Issue 17, Page 2547-2563, September 2026.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Oxysterols and mechanisms of survival signaling
, 2016 Oxysterols, a family of oxidation products of cholesterol, are increasingly drawing attention of scientists to their multifaceted biochemical properties, several of them of clear relevance to human pathophysiology.
Gamba, Paola +5 more
core +1 more source
A comprehensive review on oxysterols and related diseases
, 2021 The present review aims at providing a complete and comprehensive summary of current literature relevant to oxysterols and related diseases. Oxidation of cholesterol leads to the formation of a large number of oxidation products, generally known as ...
Samadi, Mahshid +10 more
core +1 more source
Effects of dietary fatty acids and cholesterol excess on liver injury: A lipidomic approach
Redox Biology, 2016 Lipid accumulation is the hallmark of Non-alcoholic Fatty Liver Disease (NAFLD) and has been suggested to play a role in promoting fatty liver inflammation. Previous findings indicate that during oxidative stress conditions excess cholesterol autoxidizes
Gaetano Serviddio +9 more
doaj +1 more source
Advanced Science, Volume 13, Issue 51, 14 September 2026.Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An +8 more
wiley +1 more source
Oxysterols in Metabolic Syndrome: From Bystander Molecules to Bioactive Lipids
, 2016 Oxysterols are cholesterol metabolites now considered bona fide bioactive lipids. Recent studies have identified new receptors for oxysterols involved in immune and inflammatory processes, hence reviving their appeal.
Guillemot-Legris, Owein +2 more
core +1 more source