Results 61 to 70 of about 9,669 (153)
Grasas y Aceites, 2004 Cholesterol is a molecule with a double bond in its structure, and therefore it is susceptible to oxidation leading to the formation of oxysterols. These oxidation products are found in many commonly consumed foods and are formed during their manufacture
Alfonso Valenzuela +2 more
doaj +1 more source
Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients
British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3375-3386, October 2026.Aim Imatinib pharmacokinetics exhibit large interindividual variability because of differences in CYP3A4 activity—the main imatinib‐metabolizing enzyme. While therapeutic drug monitoring is effective, it requires steady‐state conditions and frequent sampling.
Anna Sofie Buhl Rasmussen +14 more
wiley +1 more source
Detecting oxysterols in the human circulation
, 2011 Oxysterols are oxygenated metabolites of cholesterol. On the basis of in vitro experiments, oxysterols have been ascribed many regulatory roles in connection with inflammation, neurodegeneration and atherosclerosis.
David W Russell +7 more
core +1 more source
A quantitative LC-MS/MS method for analysis of mitochondrial -specific oxysterol metabolism
Redox Biology, 2020 Oxysterols are critical regulators of inflammation and cholesterol metabolism in cells. They are oxidation products of cholesterol and may be differentially metabolised in subcellular compartments and in biological fluids.
Khushboo Borah +8 more
doaj +1 more source
MedComm, Volume 7, Issue 10, October 2026.CH25H deficiency permits optimal dendritic cell activation following BCG exposure, characterized by increased IL‐12p70 production. In vivo, CH25H deficiency promotes enhanced BCG‐mediated protection and sustained IL‐2 producing T cell response. ABSTRACT Bacillus Calmette‐Guérin (BCG) remains the only licensed vaccine for tuberculosis (TB), yet its ...
Hagyu Kim +6 more
wiley +1 more source
Cholesterol homeostasis: A role for oxysterols [PDF]
, 1998 Recent experiments have identified LXRα, a nuclear hormone receptor that binds oxysterols, as a key regulator of hepatic cholesterol ...
Farese, Robert V, Accad, Michel
core +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, Volume 600, Issue 17, Page 2526-2546, September 2026.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
The production of oxysterols in bile by activated human leukocytes
, 2006 Oxysterols are naturally occurring intermediates in the conversion of cholesterol to bile acids, the major route for elimination of cholesterol. Additionally, they are important signaling agents, particularly in control of cholesterol synthesis; however,
Haigh, WG, Wong, T, Lee, SP
core +1 more source
, 2019 By-products of the olive oil mechanical extraction process are sources of high value molecules for the production of new foods and/or ingredients with higher functionality. In particular, replacing chemical additives (i.e.
V. Cardenia +5 more
core +1 more source
Involvement of 27-Hydroxycholesterol in Mitotane Action on Adrenocortical Carcinoma
Cells, 2020 Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis. Mitotane, the standard treatment for ACC, impairs adrenocortical steroid biosynthesis and cholesterol metabolism.
Antonina Germano +10 more
doaj +1 more source