Results 81 to 90 of about 9,669 (153)

On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation

Journal of Lipid Research, 2002
Oxysterols possess powerful biological activities. Some of their effects on the regulation of key enzymes are similar to those of cholesterol, but are much more potent.
Steve Meaney, Karl Bodin, Ulf Diczfalusy, Ingemar Björkhem   +3 more
doaj   +1 more source

Olive oil polyphenols reduce oxysterols -induced redox imbalance and pro-inflammatory response in intestinal cells

Redox Biology, 2018
Dietary habits may strongly influence intestinal homeostasis. Oxysterols, the oxidized products of cholesterol present in cholesterol-containing foodstuffs, have been shown to exert pro-oxidant and pro-inflammatory effects, altering intestinal epithelial
Gessica Serra, Alessandra Incani, Gabriele Serreli, Laura Porru, M.Paola Melis, Carlo I.G. Tuberoso, Daniela Rossin, Fiorella Biasi, Monica Deiana   +8 more
doaj   +1 more source

Oxysterols recruit tumor-supporting neutrophils within the tumor microenvironment: The many facets of tumor-derived oxysterols

, 2013
By binding to the liver X receptor (LXR), oxysterols inhibit the expression of chemokine (C-C motif) receptor 7 (CCR7), hence impairing the migration of dendritic cells to secondary lymphoid organs and inhibiting antitumor immune responses.
Raccosta L., Fontana R., Russo V., Traversari C.   +3 more
core   +1 more source

Changes in brain oxysterols at different stages of Alzheimer's disease: Their involvement in neuroinflammation

Redox Biology, 2016
Alzheimer's disease (AD) is a gradually debilitating disease that leads to dementia. The molecular mechanisms underlying AD are still not clear, and at present no reliable biomarkers are available for the early diagnosis.
Gabriella Testa, Erica Staurenghi, Chiara Zerbinati, Simona Gargiulo, Luigi Iuliano, Giorgio Giaccone, Fausto Fantò, Giuseppe Poli, Gabriella Leonarduzzi, Paola Gamba   +9 more
doaj   +1 more source

A panel of altered blood oxysterols in patients with mild cognitive impairment: A novel combined diagnostic marker

Pharmacological Research
Perturbed cholesterol metabolism may play an important role in the development of dementia and its preclinical stage, mild cognitive impairment (MCI). Oxysterols, the metabolites generated during cholesterol oxidation, also appear to be risk factors for ...
Yu An, Yuandi Xi, Tao Wang, Mengwei Ju, Wenjing Feng, Zhiting Guo, Xuejing Sun, Kexin Yang, Chengyan Qi, Rong Xiao   +9 more
doaj   +1 more source

Oxysterols are potential physiological regulators of ageing

, 2022
International audienceDelaying and even reversing ageing is a major public health challenge with a tremendous potential to postpone a plethora of diseases including cancer, metabolic syndromes and neurodegenerative disorders.
Silvente-Poirot, Sandrine, Poirot, Marc, de Medina, Philippe   +2 more
core   +1 more source

Bioinspired Aerobic Oxidation to Functionalize the CD Ring of the Steroid Framework: Synthesis and Stereochemical Assignments of Gargalol C and Related Oxysterols

ChemistryEurope
Aerobic oxidation to insert oxygen functional groups into the CD ring of the steroid framework was investigated using several 5,6‐α‐epoxysterol precursors. Oxidation under Schenck‐ene conditions provided oxysterols with a hydroxyl group at either C8, C9,
Hinata Togo, Yui Kanda, Shoji Kobayashi
doaj   +1 more source

Enzymatic Inactivation of Oxysterols in Breast Tumor Cells Constraints Metastasis Formation by Reprogramming the Metastatic Lung Microenvironment

Frontiers in Immunology, 2018
Recent evidence indicates that immune cells contribute to the formation of tumor metastases by regulating the pre-metastatic niche. Whether tumor-derived factors involved in primary tumor formation play a role in metastasis formation is poorly ...
Marta A. Moresco, Marta A. Moresco, Laura Raccosta, Gianfranca Corna, Daniela Maggioni, Matias Soncini, Silvio Bicciato, Claudio Doglioni, Claudio Doglioni, Vincenzo Russo   +9 more
doaj   +1 more source

Development and application of an LC-MS/MS method for the combined quantification of oxysterols and bile acids

Journal of Lipid Research
Oxysterols and bile acids are interconnected bioactive lipids playing pivotal roles in diverse physiological and pathological processes. For this reason, they are increasingly studied together for their implications in various diseases.
Martin Roumain, Giulio G. Muccioli
doaj   +1 more source

Current knowledge on the mechanism of atherosclerosis and pro-atherosclerotic properties of oxysterols

Lipids in Health and Disease, 2017
Due to the fact that one of the main causes of worldwide deaths are directly related to atherosclerosis, scientists are constantly looking for atherosclerotic factors, in an attempt to reduce prevalence of this disease.
Adam Zmysłowski, Arkadiusz Szterk
doaj   +1 more source