Results 241 to 250 of about 25,401,718 (281)

P bodies: at the crossroads of post-transcriptional pathways

Nature Reviews Molecular Cell Biology, 2007
Post-transcriptional processes have a central role in the regulation of eukaryotic gene expression. Although it has been known for a long time that these processes are functionally linked, often by the use of common protein factors, it has only recently become apparent that many of these processes are also physically connected.
Elisa Izaurralde, Ana Eulalio
exaly   +4 more sources

Phosphorothioate Antisense Oligonucleotides Bind P-Body Proteins and Mediate P-Body Assembly

Nucleic Acid Therapeutics, 2019
Antisense oligonucleotides (ASOs) regulate gene expression by binding to complementary target RNA, and ASOs can be designed to take advantage of a growing array of post RNA binding molecular mechanisms. Intracellular trafficking of ASOs influences their efficacy.
Ying, Wang, Wen, Shen, Xue-Hai, Liang, Stanley T, Crooke   +3 more
openaire   +2 more sources

The Discovery and Analysis of P Bodies

2012
The last decade has seen the discovery of a conserved class of cytoplasmic mRNP (messenger Ribonucleic Acid—Protein complexes) aggregates called Processing Bodies or P Bodies (Sheth and Parker 2003). They belong to a growing list of cytoplasmic mRNP aggregates, many of which are compositionally similar to P Bodies and consist of a host of translational
Saumya, Jain, Roy, Parker
openaire   +2 more sources

Processing body (P-body) and its mediators in cancer

Molecular and Cellular Biochemistry, 2022
In recent years, processing bodies (P-bodies) formed by liquid-liquid phase separation, have attracted growing scientific attention due to their involvement in numerous cellular activities, including the regulation of mRNAs decay or storage. These cytoplasmic dynamic membraneless granules contain mRNA storage and decay components such as deadenylase ...
Bernard Nsengimana, Faiz Ali Khan, Ebenezeri Erasto Ngowi, Xuefeng Zhou, Yu Jin, Yuting Jia, Wenqiang Wei, Shaoping Ji   +7 more
openaire   +2 more sources

GW/P-Bodies and Autoimmune Disease

2012
Human autoantibodies have performed admirably in the service of characterizing GW/P-bodies. These antibodies have provided a critical point of reference by which other proteins have been shown to be components of GW/P-bodies. In addition,autoantibodies have been used to identify new GW/P-body components, including Ge-l, GW182, RAP55, and YB-1.
Donald B, Bloch, Rita A, Nobre, Wei-Hong, Yang   +2 more
openaire   +2 more sources

RNAi and the P-body connection

Nature Cell Biology, 2005
Cytoplasmic processing bodies, also known as P-bodies, concentrate enzymes that are involved in mRNA turnover and sequester mRNAs away from the translational machinery. Strong evidence now connects the RNA interference machinery with P-body formation.
openaire   +1 more source

Intracellular trafficking of RNASET2, a novel component of P‐bodies

Biology of the Cell, 2011
AbstractBackground informationThe ribonucleases (RNases) constitute a heterogeneous group of enzymes, which exert diverse and specific biological functions. Several RNases have been shown to control gene expression and cell differentiation. RNASET2, a novel member of the Rh/T2/S family of RNases, exerts micro‐environmental control of malignancy in ...
Vidalino L., MONTI, LAURA, Haase A., Moro A., ACQUATI, FRANCESCO, TARAMELLI, ROBERTO, Macchi P.   +6 more
openaire   +4 more sources

PKA Against P Bodies

Science Signaling, 2011
Attenuation of PKA activity may be required for P body formation in yeast experiencing glucose deprivation.
openaire   +1 more source

P-bodies and mitochondria: Which place in RNA interference?

Biochimie, 2012
Micro-RNAs (miRNAs) are major actors of RNA interference (RNAi), a regulation pathway which leads to translational repression and/or degradation of specific mRNAs. They provide target specificity by incorporating into the RISC complex and guiding its binding to mRNA. Since the discovery of RNAi, many progresses have been made on the mechanism of action
Ernoult-Lange, Michèle, Bénard, Marianne, Kress, Michel, Weil, Dominique   +3 more
openaire   +3 more sources

Hsp90 is involved in the formation of P-bodies and stress granules

Biochemical and Biophysical Research Communications, 2011
Previously, we found that treatment of cells with the Hsp90 inhibitor geldanamycin (GA) leads to a substantial reduction in the number of processing bodies (P-bodies), and also alters the size and subcellular localization of stress granules. These findings imply that the chaperone activity of Hsp90 is involved in the formation of P-bodies and stress ...
Ken, Matsumoto, Michiko, Minami, Fumika, Shinozaki, Yukari, Suzuki, Keiko, Abe, Shuhei, Zenno, Shogo, Matsumoto, Yasufumi, Minami   +7 more
openaire   +2 more sources