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P Bodies and mRNA Cycle

2013
Ökaryotik hücrelerin gen ekspresyonunda translasyonun kontrolü ve mRNA yıkımı önemli bir role sahiptir. P cisimcikleri mRNA moleküllerinin depolandığı, yıkıma uğratıldığı translasyonel olarak baskı altında tutulduğu ve RNAi aracılı susturmanın yapıldığı sitoplazmik oluşumlardır.
GÜRKÖK, Tuğba   +3 more
openaire   +1 more source

EDC4 C-terminal domain scaffolds P-body assembly and links P-body dynamics to p53-mediated tumor suppression

RNA
Processing bodies (P-bodies) are membraneless organelles in eukaryotic cells that play a central role in mRNA metabolism, including mRNA decay, storage, and translational repression. However, the molecular mechanisms governing their assembly remain incompletely understood.
Yu-Hsuan Cheng   +6 more
openaire   +3 more sources

Analyzing P-Bodies and Stress Granules in Saccharomyces cerevisiae

2010
Eukaryotic cells contain at least two types of cytoplasmic RNA-protein (RNP) granules that contain nontranslating mRNAs. One such RNP granule is a P-body, which contains translationally inactive mRNAs and proteins involved in mRNA degradation and translation repression.
J Ross, Buchan   +2 more
openaire   +2 more sources

P-BODY AND CYTOSKELETON REMODELING BY ORTHOHANTAVIRUSES

ABSTRACT Orthohantaviruses, are emerging zoonotic pathogens causing life-threatening diseases in humans. The orthohantavirus genome consists of three RNA segment (vRNAs) of negative polarity, which are encapsidated by the viral nucleoprotein (N).
Hannah Sabeth Schwarzer-Sperber   +12 more
openaire   +1 more source

Analyzing P-bodies in Saccharomyces cerevisiae.

Methods in enzymology, 2009
Cytoplasmic processing bodies, or P-bodies, are RNA-protein granules found in eukaryotic cells. P-bodies contain non-translating mRNAs and proteins involved in mRNA degradation and translational repression. P-bodies, and the mRNPs within them, have been implicated in mRNA storage, mRNA degradation, and translational repression.
Tracy, Nissan, Roy, Parker
openaire   +1 more source

Ketone bodies for the failing heart: fuels that can fix the engine?

Trends in Endocrinology and Metabolism, 2021
Anthony Rosenzweig   +2 more
exaly  

Neuronal P-bodies and Transport of microRNA-Repressed mRNAs

2009
Highly polarized cells like neurons use specialized RNA transport systems to allow for local control of RNA translation, which is a key to neuronal plasticity in the brain. Several proteins, like ZPB1, FMRP, and Staufen, play an important role in transporting RNA along dendrites to the synapse, and a growing amount of evidence has highlighted the role ...
openaire   +2 more sources

Analysis of RNA Helicases in P-Bodies and Stress Granules

2012
Cytoplasmic mRNA protein complexes (mRNPs) can assemble in granules, such as processing bodies (P-bodies) and stress granules (SGs). Both P-bodies and SGs contain repressed messenger RNAs (mRNAs) and proteins that regulate the fate of the mRNA.
openaire   +2 more sources

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