Results 41 to 50 of about 21,376,824 (184)
P-glycoprotein expression in experimental thyroid dysfunction
Клиническая и экспериментальная тиреоидология, 2015 Aim. To study an expression of P-glycoprotein in the liver, lean gut, kidneys, cerebral cortex at experimental dysfunction of the thyroid gland. Materials and methods.
Aleksey Vladimirovich Shchul'kin +4 more
doaj +1 more source
Cancer Biology & Medicine, 2020 Objective: Delivery of chemotherapeutic drugs to the brain has remained a major obstacle in the treatment of glioma, owing to the presence of the blood-brain barrier and the activity of P-gp, which pumps its substrate back into the systemic circulation ...
Wu Zeng +14 more
doaj +1 more source
Pulchinenosides from Pulsatilla Chinensis Increase P‐Glycoprotein Activity and Induce P‐Glycoprotein Expression [PDF]
Evidence-Based Complementary and Alternative Medicine, 2020 Five pulchinenosides (pulchinenoside B3, pulchinenoside BD, pulchinenoside B7, pulchinenoside B10, and pulchinenoside B11) isolated from Pulsatilla chinensis (Bge) Regel saponins extract exhibited strong antitumor activities but poor gastrointestinal absorption properties.
Yali Liu +7 more
openaire +2 more sources
Scientific Reports, 2018 Overexpression of ATP-binding cassette (ABC) transporters is often linked to multidrug resistance (MDR) in cancer chemotherapies. P-glycoprotein (P-gp) is one of the best studied drug transporters associated with MDR.
A. Nanayakkara +5 more
semanticscholar +1 more source
P-glycoprotein expression in oral lichen planus
Brazilian Oral Research, 2017 : Oral lichen planus (OLP) is a stress induced inflammatory condition with malignant potency. The mdr1 (multidrug resistance) is a stress gene overexpressed in cancerous conditions and its translated form, the p-glycoprotein efflux transporter is usually
Abhishek Jana +2 more
doaj +1 more source
P-Glycoprotein and Bilirubin Disposition [PDF]
Journal of Perinatology, 2001 P-glycoprotein (Pgp), an ATP-dependent plasma membrane efflux pump, is expressed in abundance on the luminal aspect of brain capillary endothelial cells and astrocytes of the blood-brain barrier where it limits the passage of a variety of lipophilic substrates into the central nervous system.
J F, Watchko +5 more
openaire +2 more sources
Energy Transduction and Alternating Access of the Mammalian ABC Transporter P-glycoprotein
Nature, 2017 ATP binding cassette (ABC) transporters of the exporter class harness the energy of ATP hydrolysis in the nucleotide-binding domains (NBDs) to power the energetically uphill efflux of substrates by a dedicated transmembrane domain (TMD).
Brandy Verhalen +7 more
semanticscholar +1 more source
An updated patent review on P-glycoprotein inhibitors (2011-2018)
Expert Opinion on Therapeutic Patents, 2019 Introduction: P-glycoprotein is a complex ATP-ase transporter involved in physiological and pathological functions. In particular, it is involved in the onset of multidrug resistance in cancer, in ocular disease, Chronic Rhinosinusitis, CNS diseases such
M. Leopoldo +5 more
semanticscholar +1 more source
Pharmaceutics, 2020 Multidrug resistance (MDR) due to P-glycoprotein (P-gp) overexpression is a major obstacle to successful leukemia chemotherapy. The combination of anticancer chemotherapy with a chemosensitizer of P-gp inhibitor is promising to overcome MDR, generate ...
Kambere Amerigos Daddy J.C. +5 more
doaj +1 more source
ABCB1 polymorphism in clopidogrel-treated Montenegrin patients
Open Life Sciences, 2021 Clopidogrel is an antiplatelet drug that displays significant interindividual variability in treatment response. Its bioavailability depends on the function of P-glycoprotein (P-gp), which is coded by a highly polymorphic ABCB1 gene.
Mugosa Snezana +4 more
doaj +1 more source