Results 61 to 70 of about 21,376,824 (184)

P-GLYCOPROTEIN QUANTITATION IN ACUTE LEUKEMIA

Iranian Journal of Allergy, Asthma and Immunology, 2003
Multi drug resistance(MDR) is a major problem in the treatment of cancer and hemalological malignancies. This resistance is multi factorial and is the result of decreased intra cellular drug accumulation.
Mali in Nikougoftar, M. Farliadi, A.A. Pourfathollali   +2 more
doaj  

Regulation of P-Glycoprotein during Oxidative Stress

Antioxidants
P-glycoprotein (Pgp, ABCB1, MDR1) is an efflux transporter protein that removes molecules from the cells (outflow) into the extracellular space. Pgp plays an important role in pharmacokinetics, ensuring the absorption, distribution, and excretion of ...
Aleksey V. Shchulkin, Yulia V. Abalenikhina, Olga V. Kosmachevskaya, Alexey F. Topunov, Elena N. Yakusheva   +4 more
doaj   +1 more source

P-glycoprotein acts as an immunomodulator during neuroinflammation. [PDF]

PLoS ONE, 2009
BACKGROUND:Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system in which autoreactive myelin-specific T cells cause extensive tissue damage, resulting in neurological deficits.
Gijs Kooij, Ronald Backer, Jasper J Koning, Arie Reijerkerk, Jack van Horssen, Susanne M A van der Pol, Joost Drexhage, Alfred Schinkel, Christine D Dijkstra, Joke M M den Haan, Teunis B H Geijtenbeek, Helga E de Vries   +11 more
doaj   +1 more source

Bypassing P-Glycoprotein Drug Efflux Mechanisms: Possible Applications in Pharmacoresistant Schizophrenia Therapy

BioMed Research International, 2015
The efficient noninvasive treatment of neurodegenerative disorders is often constrained by reduced permeation of therapeutic agents into the central nervous system (CNS).
Famida G. Hoosain, Y. Choonara, L. Tomar, Pradeep Kumar, Charu Tyagi, L. D. du Toit, V. Pillay   +6 more
semanticscholar   +1 more source

Micelle-Forming Block Copolymers Tailored for Inhibition of P-gp-Mediated Multidrug Resistance: Structure to Activity Relationship

Pharmaceutics, 2019
Multidrug resistance (MDR) is often caused by the overexpression of efflux pumps, such as ABC transporters, in particular, P-glycoprotein (P-gp). Here, we investigate the di- and tri- block amphiphilic polymer systems based on polypropylene glycol (PPO ...
Alena Braunová, Martin Kaňa, Júlia Kudláčová, Libor Kostka, Jan Bouček, Jan Betka, Milada Šírová, Tomáš Etrych   +7 more
doaj   +1 more source

Pharmacokinetic Interactions of Herbs with Cytochrome P450 and P-Glycoprotein

Evidence-Based Complementary and Alternative Medicine, 2015
The concurrent use of drugs and herbal products is becoming increasingly prevalent over the last decade. Several herbal products have been known to modulate cytochrome P450 (CYP) enzymes and P-glycoprotein (P-gp) which are recognized as representative ...
Hyun-Jong Cho, In-Soo Yoon
semanticscholar   +1 more source

Transport of cholesterol from the endoplasmic reticulum to the plasma membrane is constitutive in CaCo-2 cells and differs from the transport of plasma membrane cholesterol to the endoplasmic reticulum

Journal of Lipid Research, 1998
The transport of newly synthesized cholesterol from its site of synthesis, the endoplasmic reticulum, to the plasma membrane was studied in CaCo-2 cells. The appearance of newly synthesized cholesterol on the cell surface was rapid. By 30 min, 50% of the
F. Jeffrey Field, Ella Born, Shubha Murthy, Satya N. Mathur   +3 more
doaj   +1 more source

P‐Glycoprotein Mediated Drug Interactions in Animals and Humans with Cancer

Journal of Veterinary Internal Medicine, 2015
Drug–drug interactions can cause unanticipated patient morbidity and mortality. The consequences of drug–drug interactions can be especially severe when anticancer drugs are involved because of their narrow therapeutic index.
K. Mealey, J. Fidel
semanticscholar   +1 more source

Evaluation of the Expression of P-Glycoprotein in Propoxur-Resistant Caco-2 Cells

Acta Medica Iranica, 2014
There is a great concern about the effect of propoxur, as one of the more common N-methyl carbamate pesticides, on human health due to its extensive use in agricultural and non-agricultural applications. Caco-2 cells became resistant to propoxur, and the
Shabnam Yazdian, Najmeh Fahham, Mohammad Hossein Ghahremani, Monireh Afzali, Narges Farsandaj, Melody Vatankhah, Seyed Nasser Ostad   +6 more
doaj  

Role of p-glycoprotein expression in predicting response to neoadjuvant chemotherapy in breast cancer-a prospective clinical study

World Journal of Surgical Oncology, 2005
Background Neoadjuvant chemotherapy (NACT) is an integral part of multi-modality approach in the management of locally advanced breast cancer. It is vital to predict response to chemotherapy in order to tailor the regime for a particular patient.
Bhatia Ashima, Bansal Anju, Saxena Sunita, Mittal Mahesh K, Singh Jai, Chintamani, Kulshreshtha Pranjal   +6 more
doaj   +1 more source