Results 101 to 110 of about 243,388 (247)

Programmable Variable‐Stiffness Multilayer Elastomer Composites With High‐Aspect‐Ratio Low‐Melting‐Point Alloy Inclusions

Advanced Materials Technologies, EarlyView.
High‐aspect‐ratio low‐melting‐point alloy inclusions are embedded within multilayer silicone laminates to create thermally programmable stiffness. Sequential activation of alloy‐rich layers produces four distinct mechanical states and reconfigures tendon‐driven actuator trajectories under the same load.
Palpolage Don Shehan Hiroshan Gunawardane, Gyan Edbert Zesiro, Hao Zhou, Gursel Alici, Mu Chiao   +4 more
wiley   +1 more source

Dynamic Fluorescence Modulation via Light‐Driven Competitive Protonation

Advanced Optical Materials, EarlyView.
A two‐component molecular system demonstrates reversible, light‐driven fluorescence write–erase cycling and thermal imaging. Illumination of a merocyanine photoacid transfers a proton to a highly efficient fluorescent pyridinium dye, switching its emission color; thermal relaxation reverses the process in the dark.
Serena X. Liu, Moritz E. Kleybolte, Colin van Dyck, Sergey I. Vagin, Preeti Gahtori, Antonio Scarpati, Razieh Firouzihaji, Diogo A. Galico, Ulrich S. Schubert, Julianne Gibbs, Alkiviathes Meldrum   +10 more
wiley   +1 more source

Basis‐Independent Geometric Phase Modulation in Circularly Birefringent Plasmonic Structures

Advanced Optical Materials, EarlyView.
Here we introduce a plasmonic metasurface composed of spatially rotated chiral spiral unit cells designed to produce space‐variant circular retardance. This generates a geometric phase ramp equivalent to a blazed grating, leading to polarization dependent diffraction orders in momentum space.
Pasha Goz, Akash Das, Andre Yaroshevsky, Yuri Gorodetski   +3 more
wiley   +1 more source

Enhancing Amphibious Flipper‐Based Locomotion Through Terrain‐Dependent Bayesian Optimization of Central Pattern Generator Control

Advanced Robotics Research, EarlyView.
A sea turtle‐inspired amphibious robot uses simulation‐guided optimization to adapt its flipper coordination to different environments. Sensitivity analysis and multiobjective Bayesian optimization identify terrain‐dependent controllers that are validated on hardware.
Nnamdi C. Chikere, Yasemin Ozkan‐Aydin
wiley   +1 more source

Comparative Modeling of Human P-gp NBD2 and Docking and Binding Mode Analysis of 8-Geranyl Chrysin as a P-gp Modulator

Journal of the Chosun Natural Science, 2012
The resistance of tumour cells against cytotoxic drug is significant limitation in successful chemotherapeutic treatment of cancer. To date, no crystal structure is available for human P-gp. We developed homology model for human P-gp NBD2 by using coordinates of transporter associated protein (TAP1).
openaire   +2 more sources

Correlations between expression levels of genes encoding multifunctional YB-1 protein, inflammatory cytokines and multidrug resistance P-gp protein in surgical material from patients with lung tuberculosis

Медицинская иммунология
YB-1 is a multifunctional protein, being a transcription factor involved in the regulation of numerous cellular processes. YB-1 is an important factor in molecular cascades that regulate the response to the pathogen invasion, inflammatory activity, as ...
M. V. Erokhina, E. N. Pavlova, E. A. Scherbakova, E. Yu. Rybalkina, L. N. Lepekha, R. V. Tarasov, E. K. Tarasova   +6 more
doaj   +1 more source

Model Predictive Control for Magnetically Actuated Cellbots

Advanced Robotics Research, EarlyView.
Magnetically actuated cellbots, formed by embedding microrobots in living cells, are steered along precise paths using a model predictive controller enhanced with a Gaussian process disturbance estimator. The data‐efficient method calibrates each cellbot individually, cutting modeling error by roughly 60% and enabling accurate navigation through cell ...
Mehdi Kermanshah, Logan E. Beaver, Max Sokolich, Fatma Ceren Kirmizitas, Ahmad Ahmad, Roberto Tron, Ron Weiss, Sambeeta Das, Calin Belta   +8 more
wiley   +1 more source

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Advanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García, Kerry R. McGreevy, Maria Eugenia Vaquero, Juan M. Suarez‐Rivero, Antonio Moreno‐Rodríguez, Antonio J. Pérez‐Pulido, Daniel Ramírez de Mingo, Anna Pallé, Helena Akiko Popiel, Andrea Santi, Mario D. Cordero, José Luis Trejo, Yoshitaka Nagai, Mariano Carrión‐Vázquez   +13 more
wiley   +1 more source

Integrating Ecology and Economics in Agent‐Based Models to Support Agricultural Policy

Advanced Science, EarlyView.
Agent‐based models are valuable tools for studying social‐ecological systems in agriculture. This review maps how existing agent‐based models represent the human and natural domains of agriculture, and discusses developments in economic and ecological agent‐based modeling.
Daniel Vedder, Judith Josephin Rakowski, Lea‐Deborah Kolb, Greta Sophie Theilen‐Loges, Sebastian Lakner, Guy Pe'er   +5 more
wiley   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source