Results 141 to 150 of about 243,388 (247)

Targeting NFAT2 for Reversing the P-gp-Mediated Multidrug Resistance to Paclitaxel by Manidipine. [PDF]

Cancers (Basel)
Zhou J, Wang N, Lin YK, Li QL, Liu RM, Hu JQ, Zhou H, Lan H, Xie Y.   +8 more
europepmc   +1 more source

Fighting Multidrug Resistance with Ruthenium-Cyclopentadienyl Compounds: Unveiling the Mechanism of P-gp Inhibition. [PDF]

J Med Chem, 2023
Teixeira RG, Salaroglio IC, Oliveira NFB, Sequeira JGN, Fontrodona X, Romero I, Machuqueiro M, Tomaz AI, Garcia MH, Riganti C, Valente A.   +10 more
europepmc   +1 more source

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

Advanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen, Danni Yang, Songying Pi, Yuhan Liu, Hongbin Huang, Feile Ye, Yuhong Lin, Zhongzhen Su, Yongquan Huang   +8 more
wiley   +1 more source

P glycoprotein (ABCB1; MDR; P-gp) [PDF]

Science-Business eXchange, 2009
openaire   +3 more sources

Bacterioruberin from <i>Haloferax mediterranei</i> Triggers Cytotoxic and Pro-Oxidant Effects in Different Solid Tumour Models, Effectively Targeting P-gp-Resistant Lung Cancer Cells. [PDF]

Int J Mol Sci
Baeza-Morales A, Pascual-García S, Martínez-Peinado P, Navarro-Sempere A, Segovia Y, Medina-García M, Pujalte-Satorre C, Rodrigues R, García M, Martínez-Espinosa RM, Vasconcelos MH, Sempere-Ortells JM.   +11 more
europepmc   +1 more source

Functional Evaluation of P-gp and Bcrp at the Murine Blood-Cerebrospinal Fluid Barrier. [PDF]

Pharm Res, 2023
Sun A, Wang J.
europepmc   +1 more source

A Multifunctional Mesoporous Janus Separator With Optimized Mass Transport Regulation Enabling 800‐Cycle Lithium‐Oxygen Batteries

Advanced Science, EarlyView.
To resolve the fundamental cycling decay of lithium‐oxygen batteries arising from lithium dendrite propagation, anode corrosion, and cathode passivation, we fabricate a mesoporous silica/polyurethane Janus separator integrating interfacial protection and mass transport modulation, which markedly enhances battery cycling stability and cycle life ...
Hailiang Mu, Anlong Liu, Kun Luo, Yaming Pang, Chengde Xie, Xiaoteng Liu, Zhihong Luo, Guangbin Zhu, Yucheng Wang, Qirong Liu, Yongbing Tang   +10 more
wiley   +1 more source

A Phase 1 Study to Assess the Effect of Fruquintinib on the Pharmacokinetics of P-gp and BCRP Substrates in Healthy Subjects. [PDF]

Clin Transl Sci
Gonzalez M, Yang Z, Schelman WR, Zhou X, Gupta N, Chien C.   +5 more
europepmc   +1 more source

Fast Programming of in‐Plane Hyperbolic Phonon Polariton Optics through Van der Waals Crystals Using the Phase‐Change Material In3SbTe2

Advanced Science, EarlyView.
Launching structures for in‐plane hyperbolic polaritons in α‐MoO3 are optically programmed through already deposited flakes into the phase‐change material In3SbTe2. Precise alignment with the flake's crystal axes, focusing of polaritons by an optically programmed disk, and a first experimental realization toward a nanocavity for in‐plane hyperbolic ...
Lina Jäckering, Umberto Saldarelli, Aaron Moos, Lukas Conrads, Enrique Terán‐García, Christian Lanza, Aitana Tarazaga Martín‐Luengo, Gonzalo Álvarez‐Pérez, Pablo Alonso‐González, Matthias Wuttig, Thomas Taubner   +10 more
wiley   +1 more source

Galanthamine Fails to Reverse P-gp-Mediated Paclitaxel Resistance in Ovarian Cancer Cell Lines. [PDF]

Biomedicines
Fonseca N, Nunes M, Silva PMA, Bousbaa H, Ricardo S.   +4 more
europepmc   +1 more source