Results 131 to 140 of about 20,489,060 (330)

Evaluation of Drug–Drug Interactions Between Clarithromycin and Direct Oral Anticoagulants Using Physiologically Based Pharmacokinetic Models

Pharmaceutics
Objective: This study assessed the pharmacokinetic (PK) interactions between clarithromycin (a P-glycoprotein [P-gp] inhibitor) and four direct oral anticoagulants (DOACs) (P-gp substrates) using physiologically based PK (PBPK) models to elucidate the ...
Zhuan Yang, Yuchen Qu, Yewen Sun, Jie Pan, Tong Zhou, Yunli Yu   +5 more
doaj   +1 more source

Multi‐Responsive Dendrimer‐Hyaluronic Acid Hydrogel With Lubricating and Immunoregulatory Functions for Synergistic Osteoarthritis Therapy

Advanced Functional Materials, EarlyView.
A hydrogel with dynamic cross‐links was formed by cross‐linking hyaluronic acid with curcumin‐preloaded, phenylboronic acid‐modified poly(amidoamine) dendrimers. This hydrogel exhibited excellent injectability and self‐healing ability, enabling controlled Cur release in response to low pH, high reactive oxygen species (ROS) generation, or mechanical ...
Junjie Liu, Mengsi Zhan, Haoyu Huang, Jianhong Wang, Cheng Ni, Xiaojun Zhou, Hannah Küttner, Cong Song, Xiangyang Shi, Andrij Pich   +9 more
wiley   +1 more source

MDR1 gene-related clonal selection and P-glycoprotein function and expression in relapsed or refractory acute myeloid leukemia [PDF]

, 2001
The expression of P-glycoprotein (P-gp), encoded by the MDR1 gene, is an independent adverse prognostic factor for response and survival in de novo acute myeloid leukemia (AML).
Boevere, M.J. (Marjan) de, Heuvel-Eibrink, M.M. (Marry) van den, Holt, B. (Bronno) van der, Pieters, R. (Rob), Sonneveld, P. (Pieter), Vossebeld, P.J. (Paula), Wiemer, E.A.C. (Erik)   +6 more
core  

Graphene Nanosheet‐Based Mixed Proton‐Electron Conducting Membranes for Efficient Hydrogen Purification

Advanced Functional Materials, EarlyView.
A monolayer graphene/phosphoric‐acid mixed proton‐electron conducting membrane combines proton‐conducting nanoconfined acid channels with electron‐conducting graphene nanosheets for efficient high‐temperature hydrogen purification. The membrane achieves nearly 100% H2/CO2 selectivity and 69 GPU hydrogen permeance at 250°C, arising from synergistic ...
Kaiqiang He, Fanmengjing Wang, Dehua Dong, Yuan Kang, Zhikao Li, Jacek J. Jasieniak, Paul A. Webley, Douglas R. MacFarlane, Huanting Wang   +8 more
wiley   +1 more source

I progressi nello studio della glicoproteina-P: dalle relazioni struttura attività alla rilevanza clinica. [PDF]

, 2015
La P-gp è nota per espellere una vasta gamma di xenobiotici (es. composti citotossici) in particolare agenti idrofobici, con un'ampia specificità di substrato, nel tratto gastrointestinale, bile e urine. Una delle caratteristiche più interessanti della P-
CUDA, CHIARA
core  

Active Learning‐Accelerated Discovery of Fibrous Hydrogels with Tissue‐Mimetic Viscoelasticity

Advanced Functional Materials, EarlyView.
Active learning accelerates the design of fibrous hydrogels that mimic the viscoelasticity of native tissues. By integrating multi‐objective optimization and closed‐loop experimentation, this approach efficiently identifies optimal formulations from thousands of possibilities and decouples elasticity and viscosity. The resulting hydrogels offer tunable
Zhengkun Chen, Zheyuan Miao, Gary Tom, Austin H. Cheng, Elizaveta Gusarova, Benjamen Zondag, Tianyi Wu, Dianoosh Kalhori, Boris Hinz, Milad Abolhasani, Alán Aspuru‐Guzik, Eugenia Kumacheva   +11 more
wiley   +1 more source

A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp

PLoS ONE, 2013
30% of epilepsy patients receiving antiepileptic drugs (AEDs) are not fully controlled by therapy. The drug transporter hypothesis for refractory epilepsy proposes that P-gp is over expressed at the epileptic focus with a role of P-gp in extruding AEDs from the brain.
Dickens, David, Yusof, Siti R., Abbott, N. Joan, Weksler, Babette, Romero, Ignacio A., Couraud, Pierre-Olivier, Alfirevic, Ana, Pirmohamed, Munir, Owen, Andrew   +8 more
openaire   +5 more sources

Progressive heart P-glycoprotein (P-gp) overexpression after experimental repetitive seizures (ERS) associated with fatal status epilepticus (FSE): Is it related with SUDEP? [PDF]

, 2014
Patients with refractory epilepsy (RE) have increased risk of Sudden Unexpected Death in Epilepsy (SUDEP), where acute and fatal heart failure is suspected.
Auzmendi, Jerónimo Andrés, Girardi, Elena Silvia, Lazarowski, Alberto Jorge, Merelli, Amalia Margarita, Orozco Suárez, Sandra, Rocha Arrieta, Luisa Lilia   +5 more
core  

Changes in the Expression of miR-381 and miR-495 Are Inversely Associated with the Expression of the MDR1 Gene and Development of Multi-Drug Resistance

, 2015
Multidrug resistance (MDR) frequently develops in cancer patients exposed to chemotherapeutic agents and is usually brought about by over-expression of P-glycoprotein (P-gp) which acts as a drug efflux pump to reduce the intracellular concentration of ...
Fan, Jun Y., Gong, Guangming, Hu, Yiqiao, Li, Zhen, Mao, Zhiyong, Ohms, Stephen J, Shannon, M. Frances, Wang, Qiao, Xu, Yan   +8 more
core   +1 more source

Solution‐Processed Two‐Dimensional Indium Oxide on Sodium‐Embedded Alumina for Reconfigurable Optoelectronic Synaptic Transistors

Advanced Functional Materials, EarlyView.
Wafer‐scale two‐dimensioanl In2Se3 oxidized into InOx on sodium‐embedded beta‐alumina enables multifunctional reconfigurable electronics. Sodium ions accumulate within distinct spatial distribution under drain‐controlle and gate‐controlled operation. Drain‐control operation gives controllability of ultraviolet‐driven optoelectronic synaptic conductance
Jinhong Min, Yonghyun Albert Kwon, Hyunbin Kim, Jihyun Kim, Myeongjin Jung, Jaewon Heo, Gwang Ya Kim, Vlastimil Mazanek, Zdeněk Sofer, In Soo Kim, Jeong Ho Cho, Hyesung Park, Sang Min Won, Joohoon Kang   +13 more
wiley   +1 more source