Results 201 to 210 of about 113,808 (269)

Multiplexed Transcriptomics for Screening Drug Combinations and Defining the Mechanism of Action of HCC Therapeutics at Single‐Cell Resolution

Cell Proliferation, EarlyView.
We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang, Haide Chen, Guoxia Wen, Yuqing Mei, Wenzhao Zhou, Bin Xu, Tingyue Zhang, Guangyan Li, Junqing Wu, Xiaoping Han, Xudong Fu, Guoji Guo, Jingjing Wang   +12 more
wiley   +1 more source

Regulation of autophagy by oncogene DJ1 via the JNK signaling pathway in human ovarian cancer cells. [PDF]

J Ovarian Res
Zhao XM, Wang K, Wang Z, Xie D, Liu H, Li P, Wang WM.   +6 more
europepmc   +1 more source

Cellular Signalling Networks in High Altitude Pulmonary Hypertension: From Canonical Pathways to Emerging Targets

Cell Proliferation, EarlyView.
This review elucidates the intricate cellular signalling networks involved in high‐altitude pulmonary hypertension (HAPH), integrating canonical pathways like HIF, MAPK and BMP with emerging targets such as Wnt/β‐catenin, Notch, Hippo‐YAP and IL‐6. It highlights potential therapeutic strategies targeting these pathways to mitigate vascular remodelling ...
Sheng Ding, Ju Chen, Zhaoyang Li, Yang Yu, Weijie Wang, Yan Liao, Jin Yang, Dianxiang Lu, Yujiang Fan   +8 more
wiley   +1 more source

Potential effect and mechanism of ultrashort wave therapy in mice with chronic rhinosinusitis. [PDF]

Biomed Rep
Xu H, Weng J, Bao Q, Jiang Y, Xiao C, Chen L.   +5 more
europepmc   +1 more source

Prevalence of new‐onset diabetes following COVID‐19 infection: A systematic review and meta‐analysis

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aim To estimate the prevalence of new‐onset diabetes in adults (≥ 18 years) following SARS‐CoV‐2 infection. Materials and Methods This meta‐analysis includes studies written in English that measured the number of adults (≥ 18 years) diagnosed with diabetes following SARS‐CoV‐2 infection.
Jordan N. Keels, Rose D. LaPlante, Christopher S. Lee, Andrew A. Dwyer   +3 more
wiley   +1 more source

Spatiotemporal regulation of MKK4 dictates switch-like JNK activation and binary cell-fate decisions. [PDF]

Nat Commun
Moriizumi H, Nakamura T, Kubota Y, Hiranuma R, Cho Y, Kawanishi T, Takeda H, Suzuki T, Takekawa M.   +8 more
europepmc   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

Tanshinone IIA prevents septicemia acute kidney injury via regulating the DUSP10/JNK/P38/NLRP3 pathway. [PDF]

Am J Transl Res
Wen D, Deng Q, Zeng Y, Li L, Yang X, Chen Q, Yan Y, Lv J.   +7 more
europepmc   +1 more source

Differential regulation of translational stress responses by herpesvirus ubiquitin deconjugases

The FEBS Journal, EarlyView.
Translating viral mRNAs is challenging due to structural features that may slow translation or induce ribosome stalling. The viral ubiquitin deconjugases encoded by human pathogenic herpesviruses regulate the cellular response to ribosomal stress by inhibiting various branches of the Ribosomal Quality Control (RQC) and activating Ribosomal Stress ...
Jiangnan Liu, Noemi Nagy, Carlos Mario Ayala‐Torres, Maria G. Masucci   +3 more
wiley   +1 more source