Results 241 to 250 of about 113,808 (269)

RASSF1A inhibits epithelial–mesenchymal transition of gastric cancer cells by downregulating P‐JNK

Cell Biology International, 2022
AbstractGastric cancer (GC) is one of the most common gastrointestinal tumors. In this study, we assessed the biological role of Ras association domain family 1 isoform A (RASSF1A) in GC cells. Expressions of RASSF1A and the relationship of RASSF1A with epithelial–mesenchymal transformation (EMT)‐related proteins were assessed in five cell lines using ...
Yuling Bin, Wenbing Deng, Hongsai Hu, Qiong Zeng, Juan Chen, Yanqing Xu, Yong Dai, Aijun Liao, Weisheng Xiao   +8 more
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WDR62 regulates mouse oocyte meiotic maturation related to p-JNK and H3K9 trimethylation

The International Journal of Biochemistry & Cell Biology, 2022
WDR62 (WD40-repeat protein 62) participates in diverse biological process, especially mitotic spindle organization via regulating centriole biogenesis and the function of centriole-associated protein. However, the role of WDR62 exerts in spindle assembly and meiotic progression control in oocytes lacking typical centrosomes remains obscure.
Yong-Sheng, Wang, Chao, Chen, Muhammad Jamil, Ahmad, Fan, Chen, Zhi-Ming, Ding, Sheng-Ji, Yang, Yang-Wu, Chen, Ze-Qun, Duan, Ming, Liu, Ai-Xin, Liang, Chang-Jiu, He, Guo-Hua, Hua, Li-Jun, Huo   +12 more
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Proteomic analysis reveals that Xbp1s promotes hypoxic pulmonary hypertension through the p‐JNK MAPK pathway

Journal of Cellular Physiology, 2021
AbstractHypoxic pulmonary hypertension (HPH) is characterized by elevated pulmonary artery resistance and vascular remodeling. Endoplasmic reticulum stress (ERS) is reported to be involved in HPH, but the underlying mechanisms remain uncertain. We found that Xbp1s, a potent transcription factor during ERS, was elevated in hypoxic‐cultured rat PASMCs ...
Hongxia Jiang, Yang Niu, Yuanzhou He, Xiaochen Li, Yongjian Xu, Xiansheng Liu   +5 more
openaire   +2 more sources

Reviving human γδT cells from apoptosis induced by IL-12/18 via p-JNK inhibition

Journal of Leukocyte Biology, 2022
AbstractγδT cells recognize and exert cytotoxicity against tumor cells independently of MHC restriction and have antigen presentation and regulatory functions to promote adaptive immune responses. They are considered as potential immune cells for cellular immunotherapy in cancer patients.
Yuan, Song, Huey Yee, Teo, Yonghao, Liu, Xiaomeng, Zhang, Jinmiao, Chen, Yongliang, Zhang, Haiyan, Liu   +6 more
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The anti-rotavirus effect of baicalin via the gluconeogenesis-related p-JNK–PDK1–AKT–SIK2 signaling pathway

European Journal of Pharmacology, 2021
Rotavirus (RV) infection is a leading cause of severe, dehydrating gastroenteritis in children 
Lijun Song, Peicheng Zhong, Xuemei Zhu, Ruoxia Zhou, Mengyue Gao, Qian Lan, Jiabo Chen, Yang Chen, Wenchang Zhao   +8 more
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Ambroxol attenuates cisplatin-induced hepatotoxicity and nephrotoxicity via inhibition of p-JNK/p-ERK

Canadian Journal of Physiology and Pharmacology, 2019
Hepatotoxicity and nephrotoxicity are important drawbacks of cisplatin. The objective of this study is to evaluate the ability of ambroxol in 2 different doses (35 and 70 mg/kg, i.p.) to protect liver and kidney from damage induced by a single dose of cisplatin (10 mg/kg, i.p.) in comparison with N-acetylcysteine (250 mg/kg, i.p.).
Abeer, Bishr, Nada, Sallam, Mahmoud, Nour El-Din, Azza S, Awad, Sanaa A, Kenawy   +4 more
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Evaluation of the p‐AKT, p‐JNK and FoxO3a function in oral epithelial dysplasia

Oral Diseases, 2017
ObjectivesTo evaluate the expression of p‐AKT, p‐JNK, FoxO3a, and Ki‐67 in samples of oral squamous cell carcinoma (OSCC) and oral epithelial dysplasias (OEDs) to understand their possible involvement in the malignant transformation process of oral lesions.Materials and MethodsTissue samples of 20 cases of OSCCs, 20 OEDs, and normal oral mucosa were ...
FN Chaves, TMM Bezerra, PG de Barros Silva, FAF Oliveira, FB Sousa, FWG Costa, APNN Alves, KMA Pereira   +7 more
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TGF-β1 Regulation of P-JNK and L-Type Calcium Channel Cav1.2 in Cortical Neurons

Journal of Molecular Neuroscience, 2018
Central nervous system (CNS) diseases can cause a series of neuronal lesions, which may be improved by the anti-apoptotic neuroprotection of transforming growth factor-beta 1 (TGF-β1). In neurons, L-type Ca2+ channels (LTCC) are mainly composed of Cav1.2 subunits. Given the implication of TGF-β1 in numerous CNS diseases, we examined the neuroprotective
Zhenning Liu, Jiangtao Sheng, Guoyi Peng, Jinhua Yang, Weiqiang Chen, Kangsheng Li   +5 more
openaire   +2 more sources