Results 61 to 70 of about 25,432,439 (260)
Hepatology, EarlyView., 2022 Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode +16 more
wiley +1 more source
JNK and ERK8 as downstream effectors of receptor tyrosine kinases [PDF]
, 2006 MAP kinases are a super-family of serine-threonine protein kinases expressed in all eukaryotic cells. In mammals, there are many MAP kinases with different biological functions, grouped in distinctly regulated groups, ERK1/2 (extracellular signal related
Iavarone, Carlo
core +1 more source
Proposed mechanism of cardiac dysfunction induced by inhibition of JNK.
, 2014 Details of the mechanism are given in Discussion. MPTP, mitochondrial permeability transition pore, p38m and P-p38m, mitochondrial p38 and P-p38; JNKm and P-JNKm, mitochondrial JNK and P-JNK.
Sabzali Javadov (665772) +1 more
core +1 more source
Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis
Advanced Science, EarlyView.Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang +9 more
wiley +1 more source
Hepatology, EarlyView., 2022 Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai +29 more
wiley +1 more source
The effects of SAA and siRNA-DUSP2/4/16 on p-ERK and p-JNK.
, 2014 (a) Effects of SAA and siRNA-DUSP4 on p-ERK(44 KDa, 42 KDa) and p-JNK(54 KDa, 46 KDa); (b) Effects of SAA and siRNA-DUSP16 on p-ERK and p-JNK; (C) Effects of SAA and siRNA-DUSP2 on p-ERK and p-JNK; Cardiomyocytes was transfected siRNA-DUSP2/4/16, then ...
Tongda Xu (173936) +7 more
core +1 more source
Advanced Science, EarlyView.The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo +20 more
wiley +1 more source
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
Frontiers in Pharmacology, 2019 Acetaminophen (APAP) is an analgesic–antipyretic drug and widely used in clinics. Its overdose may cause serious liver damage. Here, we examined the mechanistic role of c-Jun N-terminal kinase (JNK) signaling pathway in liver injury induced by different ...
Chenxi Shi +11 more
doaj +1 more source
Inhibition of JNK aggravates the recovery of rat hearts after global ischemia: the role of mitochondrial JNK. [PDF]
PLoS ONE, 2014 c-Jun N-terminal kinase (JNK), a stress-activated MAPK, is activated during cardiac ischemia-reperfusion (IR). The role of JNK inhibitors in cardioprotection against IR still remains controversial, in part, due to spill-over effects of non-specific ...
Sehwan Jang, Sabzali Javadov
doaj +1 more source