Results 81 to 90 of about 25,432,439 (260)

Co-immunoprecipitation of mitochondrial proteins with P-JNK and P-p38.

, 2014
Representative immunoblots showing interaction between P-JNK, P-p38, the MPTP components ANT, VDAC, CyP-D, and components of mitochondrial oxidative phosphorylation.
Sabzali Javadov (665772), Sehwan Jang (469679)   +1 more
core   +1 more source

Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9

Advanced Science, EarlyView.
In this study, we demonstrate that Zdhhc17, acting as a PAT, suppresses neuronal apoptosis and promotes axon regeneration after injury, thereby enhancing functional recovery following SCI. In this context, Kpna2 and Ipo9 serve as novel palmitoylation substrates of Zdhhc17, whose palmitoylation prevents the injury‐induced degradation of their proteins ...
Meixuan Chen, Huan Chen, Sining Ding, Fan Liu, Xiaofei Zheng, Yuan Wang, Ruitu Tian, Huan Li, Peilin Liu, Le Hu, Bin Liu, Limin Rong, Mangmang Li   +12 more
wiley   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

The Adaptogens Rhodiola and Schizandra Modify the Response to Immobilization Stress in Rabbits by Suppressing the Increase of Phosphorylated Stress-activated Protein Kinase, Nitric Oxide and Cortisol

Drug Target Insights, 2007
Adaptogens possess anti-fatigue and anti-stress activities that can increase mental and physical working performance against a background of fatigue or stress.
Alexander Panossian, Marina Hambardzumyan, Areg Hovhanissyan, Georg Wikman   +3 more
doaj   +2 more sources

ANGPTL4 promoted the cognitive impairment in vascular dementia via increasing integrin/p-Syk signalings induced mitochondrial autophagy and apoptosis in the hippocampus

Scientific Reports
The aim of this study was to investigate the effects and mechanisms of ANGPTL4 on cognitive impairment in vascular dementia rats. 36 SD rats were randomly divided into Sham(n= 9), VaD(n= 9), VaD + ANGPTL4 OE(n= 9), and VaD + ANGPTL4 KD(n= 9). A bilateral
Chunhong Yao, Jinfeng Wang
doaj   +1 more source

The Sequential Combination of a JNK Inhibitor and Simvastatin Protects Porcine Islets from Peritransplant Apoptosis and Inflammation

Cell Transplantation, 2011
Intraductal administration of a c-Jun NH 2 -terminal kinase (JNK) inhibitor enhances islet viability. However, its role in reducing the inflammatory response in islets is unknown.
Sang-Man Jin, Kang Seok Kim, Song-Yi Lee, Chang-Hoon Gong, Su Kyoung Park, Jun Seop Shin, Chung-Gyu Park M.D., Ph.D., Sang-Joon Kim   +7 more
doaj   +1 more source

Muscle specific JNK overactivation.

, 2013
(A) Western Blot analysis (IB) of protein lysates isolated from muscles of WT mice at 20 weeks of age when exposed to NCD and HFD using P-JNK and JNK antibodies.
Marc Schmidt-Supprian (102443), Claudia M. Wunderlich (102424), F. Thomas Wunderlich (102451), Martin Pal (102420), Gabriele Spohn (102429), Hella S. Brönneke (102436)   +5 more
core   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source

CAR-mediated repression of JNK phosphorylation.

, 2013
Primary hepatocytes (1×105 cells/well) were prepared from Car+/+ and Car−/− mice, were pretreated with either DMSO (DM) or TCPOBOP (TC; 250 nM) and were co-treated with TNFα and ActD to induce cell death.
Rick Moore (349873), Yukio Yamamoto (365626), Binfeng Lu (182721), Richard A. Flavell (25405), Masahiko Negishi (349874)   +4 more
core   +1 more source

A Postbiotic‐Inducing Ganoderma applanatum Polysaccharide Repairs the Intestinal Barrier via a Phocaeicola vulgatus ‐ Tridecylic Acid Axis

Advanced Science, EarlyView.
This study identifies GAP2, a bioactive polysaccharide fraction derived from Ganoderma applanatum, as a postbiotic inducer that repairs intestinal barrier damage in a gut microbiota‐dependent manner. GAP2 enriches Phocaeicola vulgatus, which degrades GAP2 and promotes tridecylic acid production, triggering Rho/CDC42 signaling and tight‐junction ...
Chuan Zhang, Miaoyu Li, Tiantian Li, Xiaojie Zang, Haiyang Shi, Yaru Liu, Chengcheng Zhang, Jianxin Zhao, Qixiao Zhai, Wei Chen, Fengwei Tian   +10 more
wiley   +1 more source