Results 91 to 100 of about 25,432,439 (260)

Inhibition of c-Jun N-terminal Kinase Signaling Pathway Alleviates Lipopolysaccharide-induced Acute Respiratory Distress Syndrome in Rats

Chinese Medical Journal, 2016
Background: An acute respiratory distress syndrome (ARDS) is still one of the major challenges in critically ill patients. This study aimed to investigate the effect of inhibiting c-Jun N-terminal kinase (JNK) on ARDS in a lipopolysaccharide (LPS ...
Jian-Bo Lai, Chun-Fang Qiu, Chuan-Xi Chen, Min-Ying Chen, Juan Chen, Xiang-Dong Guan, Bin Ouyang   +6 more
doaj   +1 more source

Expression and distribution of p-JNK and JNK proteins in the P7 rat brain after HI as detected by Western blot analysis and fluorescence immunolabeling.

, 2015
Samples were obtained from the cortex. Equal levels of protein samples (100 μg) were loaded, and GAPDH served as a loading control. The values are expressed as the relative optical density and represented as the mean±SD (n = 5). Total JNK protein was not
Deyuan Li (769599), Dezhi Mu (417879), Jinlin Wu (116930), Xihong Li (434216), Yi Qu (262233), Jun Tang (32983), Tao Xiong (287683), Jinhui Li (625245), Li Zhang (8200)   +8 more
core   +1 more source

Checkpoint‐Directed Glycoengineering Reprograms the Vascular Lumen for Siglec‐Mediated Immune Regulation

Advanced Science, EarlyView.
Checkpoint‐directed glycoengineering installs sialylated ligands on the donor vascular lumen during ex vivo preservation, creating a localized Siglec‐7/9‐engaging interface. The engineered glycocalyx suppresses immune‐cell activation, complement deposition, and microvascular injury in arterial and kidney allografts while preserving endothelial ...
Md Mohosin Rana, Javairia F. Rahim, Aaron P. Bernstein, Peyman Malek Mohammadi Nouri, Lyann Sim, Winnie Enns, Jenice M. Dumlao, Haiming D. Luo, Irina Chafeeva, Hong‐Ming Chen, Aizhou Wang, Jiao‐Jing Wang, Edward N. Schmidt, Zheng Jenny Zhang, Marcelo Cypel, Christopher Nguan, Matthew S. Macauley, Stephen G. Withers, Jonathan C. Choy, Jayachandran N. Kizhakkedathu   +19 more
wiley   +1 more source

Acupuncture inhibits JNK activation after SCI.

, 2013
At POD 31, 1 h after AP treatment, lumbar (L4-L5) spinal tissues were isolated and total lysates or frozen tissue sections were prepared as described in the Methods section (n = 4). (a) Western blots of p-JNK.
Jee Y. Lee (455790), Doo C. Choi (455791), Tae Y. Yune (455793), Tae H. Oh (455792)   +3 more
core   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Saikosaponin A Mediates the Anti-Acute Myeloid Leukemia Effect via the P-JNK Signaling Pathway Induced by Endoplasmic Reticulum Stress

Drug Design, Development and Therapy
This study aims to investigate the antitumor effects of saikosaponin A (SSA) on acute myeloid leukemia (AML) and elucidate its underlying mechanisms, particularly focusing on the endoplasmic reticulum stress (ERS)-mediated MAPK-p-JNK signaling pathway.The inhibitory effects of SSA on the proliferation of AML cell lines K562 and HL60 were evaluated ...
Xiao-Hong Sun, Yi-Hong Chai, Xiao-Teng Bai, Hong-Xing Li, Pan-Pan Yang, Ya-Ming Xi   +5 more
openaire   +5 more sources

DLK silencing attenuated neuron apoptosis through JIP3/MA2K7/JNK pathway in early brain injury after SAH in rats

Neurobiology of Disease, 2017
Objective: Dual leucine zipper kinase (DLK/MA3K12) has been reported involved in apoptosis and neuronal degeneration during neural development and traumatic brain injury. This study was designed to investigate the role of DLK with its adaptor protein JNK
Cheng Yin, Guang-fu Huang, Xiao-chuan Sun, Zongduo Guo, John H. Zhang   +4 more
doaj   +1 more source

A stiff ECM activates the ERK and JNK signaling pathway.

, 2015
(A) hMSCs were plated on a 1.37 or 4.47 kPa hydrogel, and after 12 h, cell lysates were prepared and analyzed by immunoblotting. To assess the activity of ERK and JNK, phosphorylated ERK (p-ERK) and phosphorylated JNK (p-JNK) antibodies were used ...
Mi Gyeong Jeong (782116), Mi Ran Byun (782114), A. Rum Kim (540744), Hang Jun Cho (540745), Jun-Ha Hwang (540743), Kyung Min Kim (540742), Jeong-Ho Hong (540747), Eun Sook Hwang (181978), Yo Han Lee (782115), Juwon Kim (478195)   +9 more
core   +1 more source

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

Oxidative stress in NSC-741909-induced apoptosis of cancer cells

Journal of Translational Medicine, 2010
Background NSC-741909 is a novel anticancer agent that can effectively suppress the growth of several cell lines derived from lung, colon, breast, ovarian, and kidney cancers.
Huang Peng, Wang Li, Wu Shuhong, Guo Wei, Wei Xiaoli, Liu Jinsong, Fang Bingliang   +6 more
doaj   +1 more source