Results 111 to 120 of about 25,432,439 (260)
Respiratory Research, 2006 Background Although pneumococcal pneumonia is one of the most common causes of death due to infectious diseases, little is known about pneumococci-lung cell interaction. Herein we tested the hypothesis that pneumococci activated pulmonary epithelial cell
Rosseau Simone +8 more
doaj +1 more source
Advanced Science, EarlyView.In hepatocytes, CBX2 promotes H3K4me3 enrichment at the Orai1 promoter to enhance Orai1 transcriptional activation, thereby increasing intracellular Ca2+ levels. The elevated Ca2+ activates the CaMKK2‐AMPK signaling cascade, resulting in ACC phosphorylation and downstream metabolic regulation. This cascade suppresses de novo lipogenesis (Fasn, Acc, Scd‐
Xiang Wei +18 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2008 目的观察磷酸化JNK（p-JNK）在小鼠腹水型肝癌高、低淋巴道转移株（Hca-F、Hca-P）中的表达水平,分析其在这两个细胞株中表达的关系及意义,以进一步探讨JNK基因在肝癌淋巴道转移过程中的作用。方法以小鼠腹水型肝癌淋巴道高转移株（Hca-F）和低转移株（Hca-P）为研究对象,采用Western Blot检测p-JNK在Hca-F和Hca-P两细胞株的表达。结果p-JNK在Hca-F细胞株中的表达显著高于Hca-P,二者间差异有显著性 ...
张宇虹 +6 more
doaj
Frontiers in Immunology, 2019 Chikungunya virus (CHIKV), a mosquito-borne Alphavirus, is endemic in different parts of the globe. The host macrophages are identified as the major cellular reservoirs of CHIKV during infection and this virus triggers robust TNF production in the host ...
Tapas Kumar Nayak +8 more
doaj +1 more source
Effect of JNK inhibitor on release of KC, JNK activity and intramacrophagic parasite growth.
, 2014 (A) Resident macrophages were infected or not with L. major in the presence of solvent or the indicated MAPK inhibitors. The levels of KC were determined by ELISA after 20 h of infection. (B) Macrophages were infected or not in the presence of solvent or
Norton Heise (197106) +9 more
core +1 more source
A UBE3A‐UTX Proteostasis‐Epigenetic Axis Governs Hypothalamic Energy Homeostasis
Advanced Science, EarlyView.Ubiquitin protein ligase E3A (UBE3A) regulates hypothalamic energy homeostasis and promotes degradation of the histone demethylase UTX (KDM6A). Neuronal UBE3A loss increases susceptibility to diet‐induced obesity and is accompanied by UTX accumulation, reduced histone H3 lysine 27 trimethylation, and altered endoplasmic reticulum stress‐responsive gene
Junekyoung Lee +7 more
wiley +1 more source
BMC Cancer, 2011 Background Cucurbitacin-I (JSI-124) is potent inhibitor of JAK/STAT3 signaling pathway and has anti-tumor activity in a variety of cancer including B cell leukemia.
Ishdorj Ganchimeg +2 more
doaj +1 more source
Quantification of PTEN and p-JNK expression.
Bar charts showing the ratios of PTEN to β-actin, and phosphorylated JNK to total protein in BMDMs transfected with the miRNA mimics for 6 h (n = 3; ns: no significance, *P (TIF)
Zihao Wang (845023) +8 more
core +1 more source
, 2016 Murine BMMs were uninfected, infected with a S1PR2 shRNA lentivirus, or infected with a control shRNA lentivirus (moi 50) for 72 h. Then the cells were either unstimulated or stimulated with Aa (1.5 CFU/cell) for 1 to 4 h. (A) S1PR2, p-PI3K, p-ERK, p-JNK,
Hong Yu (6528)
core +1 more source
Poly(I:C)‐Activated Nasal Fibroblasts Promote Eosinophil Recruitment in CRSwNP
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by persistent mucosal inflammation and eosinophilic infiltration. Although epithelial and immune cells have been widely studied, the role of nasal fibroblasts in innate immune activation and eosinophil recruitment remains unclear.
Chaewon Shin +5 more
wiley +1 more source