Results 121 to 130 of about 25,432,439 (260)
AngII treatment increased JNK and P-ERK expression in HUVECs by western blotting.
, 2014 (A) JNK and P-ERK expression levels. (B) Semi-quantitative analysis of the JNK levels. (C) Semi-quantitative analysis of the levels. Different symbols indicate statistical significance (p0.05).
Qing Zhu (349093) +9 more
core +1 more source
Animal Research and One Health, EarlyView.Schematic diagram illustrating how miR‐222 promotes bovine intramuscular adipogenesis by targeting DDIT4 to activate the mTORC1 signaling pathway. ABSTRACT Intramuscular fat (IMF) is a key determinant of beef quality, particularly with respect to tenderness, flavor, and juiciness.
Jianbing Tan +7 more
wiley +1 more source
Journal of Biomedical Science, 2012 Background Based on an experimental brain stem death model, we demonstrated previously that activation of the mitogen-activated protein kinase kinase 1/2 (MEK1/2)/extracellular signal-regulated kinase 1/2 (ERK1/2)/mitogen-activated protein kinase signal ...
Chang Alice YW
doaj +1 more source
Effects of 4% HCM, LY294002 and SP600125 on the activities of PI3-K, Akt and JNK.
, 2014 The phosphorylation levels of Akt, PI3-K, and JNK significantly increased in HCM. High levels of p-Akt and p-PI3-K induced by HCM were blocked by LY294002 (B, C). The level of p-JNK was blocked in the presence of SP600125 (E).
Ming Cai (342151) +3 more
core +1 more source
Animal Research and One Health, EarlyView.This study analyzed the spleen transcriptomes of different chicken breeds, identified key differentially expressed genes (EGR1, FOS, and DUSP1) that regulate resistance to Salmonella infection, and elucidated the underlying regulatory mechanisms, thereby providing new targets for disease‐resistant breeding in poultry.
Zixuan Wang +8 more
wiley +1 more source
, 2014 A: Immunoblotting of total and phosphorylated JNK at day 7. B: Immunoblotting of total and phosphorylated JNK at day 12. C: The ratio of phosphorylated JNK to total JNK from data shown in A. D: The ratio of phosphorylated JNK to total JNK from data shown
Jielin Duan (520729) +12 more
core +1 more source
Arthritis &Rheumatology, EarlyView.Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of testicular receptor 4 (TR4; or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated ...
Yun Zhang +16 more
wiley +1 more source
针刺研究, 2016 Objective To observe the effect of acupuncture on c-jun N-terminal Kinase(JNK)signaling in the hippocampus in rats with forced-swimming stress,so as to reveal its underlying mechanism in relieving depression-like motor response.Methods Forty-eight ...
GUO Yu +10 more
doaj +2 more sources
Expression of JNK1, JNK2, p-JNK1 and p-JNK2 protein in RCECs.
, 2013 RCECs cultured in NOP (normal osmotic pressure, 312mOsM) (1), HOP (high osmotic pressure, 500mOsM) (2), HOP+NAC (10 mM) (3), HOP+ DPI (10 µM) (4), HOP+ JNK inhibitor SP600125 (25 µM) (5) for 24 h.
Yihui Chen (446576) +5 more
core +1 more source
Human Monocytic Models Reveal Genotype‐Dependent Inflammatory Programs in VEXAS Syndrome
Arthritis &Rheumatology, EarlyView.Objective VEXAS syndrome is a severe X‐linked autoinflammatory disorder caused by somatic mutations in ubiquitin‐like modifier activating enzyme 1 (UBA1), with clinical outcomes that vary by UBA1 genotype. We aimed to elucidate genotype‐specific inflammatory programs and identify potential therapeutic targets.
Kana Higashitani +10 more
wiley +1 more source