Results 131 to 140 of about 25,432,439 (260)

ABT-737 activated JNK and c-Jun.

, 2013
HeLa cells were treated with various concentrations of ABT737 for 24 h (A) or with 10 µM ABT737 for the indicated periods (B). After treatments, cell lysates were analyzed by immunoblotting with JNK, phospho-JNK, c-Jun and phospho-c-Jun antibodies.
Yue-Bo Yang (292940), Jian Gu (23649), Huan Wang (109286), Hui-Min Shen (292941), Tian Li (194773), Xiao-Mao Li (292942)   +5 more
core   +1 more source

Dual Effects of β‐TrCP2 Deletion in Bone Homeostasis: Suppression of Osteoclastogenesis and Enhancement of Osteoblast Activity

Arthritis &Rheumatology, EarlyView.
Objective The aim of this study was to elucidate the role of beta‐transducin repeat‐containing protein 2 (β‐TrCP2) in bone homeostasis for its potential as a therapeutic target for osteoporosis. Methods The role of β‐TrCP2 in bone phenotypes was investigated using systemic β‐TrCP1 knockout (KO) and β‐TrCP2KO mice, along with myeloid‐specific ...
Woo Jung Kim, Sora Han, Hye In Ka, Sun Young Lee, Jiwon Kim, Hyunjeong Joo, Sujung Soh, Gaeun Oh, Kyung Hyun Yoo, Seung Hyun Han, Yeongkag Kwon, Choogon Lee, Kyung‐Hyun Park‐Min, Se Hwan Mun, Young Yang   +14 more
wiley   +1 more source

NF-κB inhibitor induces JNK activation, and TNF-stimulated JNK activity is independent of NF-κB signaling.

, 2014
A. Jurkat cells were treated with indicated concentrations of BAY11-7082 for 2 hours. NF-κB activity was examined by Western blotting to detect p-p65 NF-κB levels. B.
Jun Zhang (48506), Jiwang Zhang (50619), Zhou Zhang (197948), Xinli Liu (43592), Jing Li (10611), Andrew Volk (677115), Peter Breslin (50614)   +6 more
core   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

IRE1/p‑JNK/NRF2 axis-mediated GPX4 upregulation underlies ferroptosis resistance in rheumatoid arthritis fibroblast-like synoviocytes

Arthritis Research & Therapy
Rheumatoid arthritis fibroblast‑like synoviocytes (RA‑FLS) exhibit chronic endoplasmic reticulum stress with activation of the IRE1/phospho‑JNK arm of the unfolded protein response; yet, they remain resistant to apoptosis. Although ferroptosis has been implicated in the pathogenesis of rheumatoid arthritis, the mechanisms underlying ferroptosis ...
Liu, Jiaxi, Xie, Wenhui, Cao, Yongping, Zhang, Liang, Geng, Yan, Zhang, Zhuoli   +5 more
openaire   +3 more sources

Elevated pressure did not activate p38 or JNK stress signalling pathways.

, 2015
Phosphorylation of (A) p38 and (B) JNK, relative to their total expression, did not significantly alter with fluctuating pressure in HORCs (n = 3; 15 min- p38 p = 0.769, JNK p = 0.354; 30 min—p38 p = 0.696, JNK p = 0.667; 60 min—p38 p = 0.232, JNK p = 0 ...
David C. Broadway (688046), Claire Everitt (688047), Julie Sanderson (688048), Amal Aldarwesh (688044), Jeremy D. Rhodes (688045), Andrew Osborne (515425)   +5 more
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Infection with L. major activates the SAPK/JNK pathway.

, 2014
Resident (A) or inflammatory (B) B6 adherent macrophages were infected or not with L. major (Lm). After 4 h, cell extracts were obtained and the levels of JNK, p-JNK and p-c-Jun were determined by western blotting.
Norton Heise (197106), Marise P. Nunes (249611), Marcela F. Lopes (164688), Kamila Guimarães-Pinto (507878), George A. DosReis (507880), Ana Caroline Costa-da-Silva (507877), Flávia L. Ribeiro-Gomes (5657473), Alessandra A. Filardy (507876), Célio G. Freire-de-Lima (507879), Carolina M. Koeller (197098)   +9 more
core   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

The effect of STAMP2 gene overexpression on the phosphorylation of JNK in WAT and BAT of ApoE^−/−/LDLR^−/− mice.

, 2013
A: Representative Western blot of adipose tissue P-JNK and JNK; B: Western blot analysis of P-JNK/JNK.
Ming Zhong (151097), Yun Zhang (131894), Lu Han (151620), Meng-Xiong Tang (484429), Wei Zhang (405), Jia Wang (51945), Hua Wang (13530), Yun Ti (484430), Zhi-Hao Wang (151090), Wen-Yuan Ding (484431)   +9 more
core   +1 more source