Results 151 to 160 of about 25,432,439 (260)
Journal of Translational MedicineBackground Mallory-Denk bodies (MDBs) are characteristic proteins and inflammatory aggregates appeared in drug-induced chronic liver injury and various chronic liver disease.
Yi Shi +8 more
doaj +1 more source
Effects of HFru and HFat on JNK and IKK activation.
, 2012 After one week of HFru or HFat feeding, liver homogenates were immunoblotted for p-JNK/t-JNK (A), and p-IKKα/β/t-IKKα/β (B) and t-IKBα (C). Each lane represents a single mouse.
Gregory J. Cooney (183923) +9 more
core +1 more source
The expression of p-ERK1/2, p-JNK, Bcl-2 and Bax.
, 2013 The effects of luteolin and SP600125 on the expression of total ERK and p-ERK (A, B), Bcl-2 (C, D) total JNK and p-JNK (E, F), Bax (G, H). After 2 h reperfusion, the myocytes were harvested to detect protein expressions by western blot analysis.
Hong Sun (132232) +8 more
core +1 more source
Butyrate ameliorates acute‐on‐chronic liver failure by regulating macrophage polarization
iMetaOmics, EarlyView.Multi‐omics profiling identifies progressive microbiota‐metabolism‐immunity axis dysfunction in acute‐on‐chronic liver failure (ACLF), characterized by gut dysbiosis, reduced butyrate production, intestinal barrier disruption, microbial translocation, and pro‐inflammatory macrophage polarization, thereby exacerbating hepatic inflammation and fibrosis ...
Jing Xiao +10 more
wiley +1 more source
ERK/JNK pathway participated in DHM-mediated apoptosis in A2780 cells.
, 2019 A. A2780 cells were treated with various concentrations of DHM for 48 h, and the expressions of p-JNK/JNK, p-p38/p38MAPK and p-ERK/ERK were evaluated using western blot. B.
Yongfen Yi (550157) +4 more
core +1 more source
Interdisciplinary Medicine, EarlyView.Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong +15 more
wiley +1 more source
Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis
Interdisciplinary Medicine, EarlyView.Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar +18 more
wiley +1 more source
Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review
Journal of Applied Toxicology, EarlyView.ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli +5 more
wiley +1 more source
Shikonin Promotes Apoptosis in Multiple Myeloma Cells Through the PKM2‐AMPK‐PGC1α Metabolic Axis
Journal of Clinical Laboratory Analysis, EarlyView.High PKM2 expression in MM is associated with a poor prognosis. Shikonin represents a promising PKM2‐targeted agent for MM therapy, offering a unique metabolic intervention strategy to improve drug resistance, bone disease, and the immune microenvironment. ABSTRACT Background Multiple myeloma (MM) is an incurable plasma malignancy.
Fengping Peng +7 more
wiley +1 more source
Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives
JSFA reports, EarlyView.Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz +10 more
wiley +1 more source